AutismKB 2.0

Annotation Detail for CDKL5


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Basic Information Top
Gene Symbol:CDKL5 ( ISSX,STK9 )
Gene Full Name: cyclin-dependent kinase-like 5
Band: Xp22.13
Quick LinksEntrez ID:6792; OMIM: 300203; Uniprot ID:CDKL5_HUMAN; ENSEMBL ID: ENSG00000008086; HGNC ID: 11411
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
171Phosphotyrosine.
306Phosphoserine.
375Phosphoserine.
377Phosphoserine.
407Phosphoserine.
476Phosphoserine.
488Phosphoserine.
529Phosphoserine.
646Phosphoserine.
681Phosphoserine.
720Phosphoserine.
726Phosphoserine.
761Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
24Phosphotyrosine(SRC)HMM predict
57Phosphothreonine(PKC)HMM predict
167N-linkedHMM predict
288Phosphothreonine(PKC)HMM predict
306Phosphoserine(CDC2)HMM predict
306Phosphoserine(CDK)HMM predict
343Phosphoserine(CK1)HMM predict
377Phosphoserine(ATM)HMM predict
388Phosphoserine(ATM)HMM predict
392Phosphoserine(IKK)HMM predict
393Phosphothreonine(CK2)HMM predict
433Phosphotyrosine(Jak)HMM predict
446Phosphoserine(PKA)HMM predict
450Phosphoserine(CK2)HMM predict
451Phosphoserine(ATM)HMM predict
453Phosphoserine(IKK)HMM predict
477O-linkedHMM predict
479Phosphoserine(CDC2)HMM predict
481PhosphoserineHMM predict
495Phosphoserine(CK1)HMM predict
497Phosphoserine(IKK)HMM predict
497Phosphoserine(CK1)HMM predict
514O-linkedHMM predict
526Phosphoserine(MAPK)HMM predict
526Phosphoserine(IKK)HMM predict
529Phosphoserine(MAPK)HMM predict
529Phosphoserine(IKK)HMM predict
529Phosphoserine(CDC2)HMM predict
529O-linkedHMM predict
531Phosphothreonine(MAPK)HMM predict
531Phosphothreonine(CDC2)HMM predict
536Phosphoserine(PKA)HMM predict
543Phosphoserine(CDC2)HMM predict
543Phosphoserine(CDK)HMM predict
561Phosphothreonine(PKC)HMM predict
561Phosphothreonine(PKA)HMM predict
562Phosphothreonine(PKC)HMM predict
565Phosphoserine(PKA)HMM predict
584Phosphoserine(CAMK2)HMM predict
584Phosphoserine(CK1)HMM predict
584Phosphoserine(IKK)HMM predict
594SulfotyrosineHMM predict
598Phosphotyrosine(INSR)HMM predict
600Phosphoserine(CDC2)HMM predict
603Phosphoserine(CDK)HMM predict
646Phosphoserine(CDC2)HMM predict
667Phosphothreonine(PKC)HMM predict
681Phosphoserine(CAMK2)HMM predict
686Phosphotyrosine(Abl)HMM predict
704Phosphotyrosine(Abl)HMM predict
720Phosphoserine(CDC2)HMM predict
737Phosphoserine(PKG)HMM predict
738O-linkedHMM predict
738Phosphoserine(PKB)HMM predict
741O-linkedHMM predict
743Phosphoserine(CK1)HMM predict
744Phosphoserine(CK1)HMM predict
745Phosphoserine(CK1)HMM predict
748N-linkedHMM predict
792Phosphothreonine(PKC)HMM predict
812O-linkedHMM predict
813Phosphothreonine(MAPK)HMM predict
813Phosphothreonine(CDK)HMM predict
833Phosphoserine(ATM)HMM predict
880Phosphoserine(ATM)HMM predict
917Phosphoserine(ATM)HMM predict
959O-linkedHMM predict
960Phosphoserine(MAPK)HMM predict
960Phosphoserine(CDC2)HMM predict
960O-linkedHMM predict
972Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001037343
  • Location:chrX 18370264-18581667
  • strand:+
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog ESGSE20650 18389395 18390068 673 0
Nanog ESGSE20650 18493851 18494181 330 0
Oct1 HelaGSE14283 18439863 18439904 41 0
Oct1 HelaGSE14283 18446190 18446220 30 0
Oct1 HelaGSE14283 18447679 18447722 43 0
Oct1 HelaGSE14283 18447937 18447968 31 0
Oct1 HelaGSE14283 18454726 18454792 66 0
Oct1 HelaGSE14283 18467110 18467156 46 0
Oct1 HelaGSE14283 18467249 18467288 39 0
Oct1 HelaGSE14283 18472615 18472657 42 0
Oct1 HelaGSE14283 18505958 18506031 73 0
Oct1 HelaGSE14283 18512141 18512174 33 0
Oct4 hESGSE17917 18554761 18554916 155 0
RARA MCF7GSE15244 18548301 18548746 445 0
hScc1 CdLSGSE12603 18564763 18564984 221 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
27415 mRNA CDKL5 chrX 18203413 18431402 128 mRNA RS1 chrX 18419700 18428314Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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