AutismKB 2.0

Annotation Detail for SYN1


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Basic Information Top
Gene Symbol:SYN1 ( SYN1a,SYN1b,SYNI )
Gene Full Name: synapsin I
Band: Xp11.3-p11.23
Quick LinksEntrez ID:6853; OMIM: 313440; Uniprot ID:SYN1_HUMAN; ENSEMBL ID: ENSG00000008056; HGNC ID: 11494
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
9Phosphoserine; by CaMK1 and PKA.
39Phosphoserine.
55O-linked (GlcNAc) (By similarity).
62Phosphoserine (By similarity).
67Phosphoserine (By similarity).
87O-linked (GlcNAc) (By similarity).
96O-linked (GlcNAc) (By similarity).
103O-linked (GlcNAc) (By similarity).
261O-linked (GlcNAc) (By similarity).
312Phosphotyrosine (By similarity).
337Phosphothreonine (By similarity).
427Phosphoserine.
432O-linked (GlcNAc) (By similarity).
510Phosphoserine (By similarity).
512Phosphothreonine (By similarity).
520Phosphoserine (By similarity).
526O-linked (GlcNAc) (By similarity).
551Phosphoserine.
553Phosphoserine.
564O-linked (GlcNAc) (By similarity).
568Phosphoserine; by CaMK2.
578O-linked (GlcNAc) (By similarity).
605Phosphoserine; by CaMK2.
665Phosphoserine (By similarity).
704Phosphoserine (By similarity).
Location(AA) Modifications Resource
9Phosphoserine (by CaMK1 and PKA).Swiss-Prot 53.0
39PhosphoserinePhospho.ELM 6.0
39Phosphoserine.Swiss-Prot 53.0
55O-linked (GlcNAc) (By similarity).Swiss-Prot 53.0
62Phosphoserine (By similarity).Swiss-Prot 53.0
67Phosphoserine (By similarity).Swiss-Prot 53.0
87O-linked (GlcNAc) (By similarity).Swiss-Prot 53.0
96O-linked (GlcNAc) (By similarity).Swiss-Prot 53.0
103O-linked (GlcNAc) (By similarity).Swiss-Prot 53.0
261O-linked (GlcNAc) (By similarity).Swiss-Prot 53.0
337Phosphothreonine (By similarity).Swiss-Prot 53.0
427Phosphoserine.Swiss-Prot 53.0
427PhosphoserinePhospho.ELM 6.0
432O-linked (GlcNAc) (By similarity).Swiss-Prot 53.0
438Phosphoserine (KIS)Phospho.ELM 6.0
510Phosphoserine (By similarity).Swiss-Prot 53.0
512Phosphothreonine (By similarity).Swiss-Prot 53.0
520Phosphoserine (By similarity).Swiss-Prot 53.0
526O-linked (GlcNAc) (By similarity).Swiss-Prot 53.0
551Phosphoserine (CDK
551Phosphoserine.Swiss-Prot 53.0
553Phosphoserine.Swiss-Prot 53.0
553PhosphoserinePhospho.ELM 6.0
564O-linked (GlcNAc) (By similarity).Swiss-Prot 53.0
568Phosphoserine (by CaMK2).Swiss-Prot 53.0
578O-linked (GlcNAc) (By similarity).Swiss-Prot 53.0
605Phosphoserine (by CaMK2).Swiss-Prot 53.0
605Phosphoserine (PAK
665Phosphoserine (By similarity).Swiss-Prot 53.0
704Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
9Phosphoserine(PKA)HMM predict
9Phosphoserine(PKG)HMM predict
9Phosphoserine(CAMK2)HMM predict
39O-linkedHMM predict
39Phosphoserine(IKK)HMM predict
39Phosphoserine(CDC2)HMM predict
43Phosphothreonine(MAPK)HMM predict
43O-linkedHMM predict
43O-linkedHMM predict
48O-linkedHMM predict
55O-linkedHMM predict
62Phosphoserine(MAPK)HMM predict
62Phosphoserine(CDC2)HMM predict
62O-linkedHMM predict
67O-linkedHMM predict
67Phosphoserine(CDC2)HMM predict
67Phosphoserine(IKK)HMM predict
67Phosphoserine(CDK)HMM predict
87O-linkedHMM predict
88O-linkedHMM predict
108MethylarginineHMM predict
198Phosphotyrosine(EGFR)HMM predict
215Phosphoserine(CK1)HMM predict
241Phosphothreonine(PKC)HMM predict
261O-linkedHMM predict
264Phosphotyrosine(SRC)HMM predict
432O-linkedHMM predict
436Phosphothreonine(MAPK)HMM predict
438O-linkedHMM predict
438Phosphoserine(CDC2)HMM predict
476MethylarginineHMM predict
502Phosphoserine(CDC2)HMM predict
502PhosphoserineHMM predict
510O-linkedHMM predict
510Phosphoserine(CDC2)HMM predict
512O-linkedHMM predict
513Phosphoserine(IKK)HMM predict
520Phosphoserine(IKK)HMM predict
520Phosphoserine(ATM)HMM predict
520O-linkedHMM predict
526O-linkedHMM predict
533Phosphoserine(PKG)HMM predict
551Phosphoserine(CDK)HMM predict
551Phosphoserine(MAPK)HMM predict
551O-linkedHMM predict
551Phosphoserine(CDC2)HMM predict
553Phosphoserine(CDK)HMM predict
553Phosphoserine(CDC2)HMM predict
564O-linkedHMM predict
567Phosphothreonine(PKA)HMM predict
568Phosphoserine(CAMK2)HMM predict
568O-linkedHMM predict
568Phosphoserine(IKK)HMM predict
570O-linkedHMM predict
578O-linkedHMM predict
578O-linkedHMM predict
587MethylarginineHMM predict
605Phosphoserine(CAMK2)HMM predict
605O-linkedHMM predict
605O-linkedHMM predict
605Phosphoserine(IKK)HMM predict
605Phosphoserine(PKG)HMM predict
618O-linkedHMM predict
624O-linkedHMM predict
641Phosphoserine(ATM)HMM predict
661N-linkedHMM predict
663Phosphoserine(ATM)HMM predict
683Phosphoserine(ATM)HMM predict
691Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006950
  • Location:chrX 47316244-47364199
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 47364045 47364625 580 136
CTCF G2GSE9613 47364214 47364580 366 198
CTCF G2GSE9613 47364819 47365261 442 841
Myc K562GSE19551 47364163 47364661 498 213
NRSF JurkatGSE13047 47363573 47365429 1856 302
NRSF mAbJurkat 47364447 47367897 3450 1973
NRSF-mono JurkatQuESTdata 47363572 47365279 1707 226
NRSF-poly JurkatQuESTdata 47363613 47365051 1438 133
hScc1 G2GSE9613 47364214 47364580 366 198
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 47326255 47327001 746 0
CTCF G2GSE9613 47317320 47319146 1826 0
CTCF G2GSE9613 47321372 47323331 1959 0
CTCF G2GSE9613 47363749 47363872 123 0
Fos K562GSE19551 47357499 47357811 312 0
H3ac HepG2E 47317564 47318279 715 0
NRSF mAbJurkat 47360731 47363417 2686 0
Oct1 HelaGSE14283 47320590 47320622 32 0
Oct1 HelaGSE14283 47342141 47342185 44 0
Oct1 HelaGSE14283 47347601 47347640 39 0
P300 T30-glioblastomaGSE21026 47326216 47327030 814 0
TFAP2C MCF7GSE21234 47326417 47326814 397 0
TFAP2C MCF7GSE21234 47332469 47332963 494 0
hScc1 BcellGSE12603 47363608 47364611 1003 0
hScc1 G2GSE9613 47317173 47319015 1842 0
hScc1 G2GSE9613 47321698 47323259 1561 0
hScc1 G2GSE9613 47362425 47363214 789 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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