AutismKB 2.0

Annotation Detail for MAP3K7


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Basic Information Top
Gene Symbol:MAP3K7 ( MEKK7,TAK1,TGF1a )
Gene Full Name: mitogen-activated protein kinase kinase kinase 7
Band: 6q15
Quick LinksEntrez ID:6885; OMIM: 602614; Uniprot ID:M3K7_HUMAN; ENSEMBL ID: ENSG00000135341; HGNC ID: 6859
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
184Phosphothreonine; by autocatalysis
187Phosphothreonine; by autocatalysis.
192Phosphoserine; by autocatalysis
389Phosphoserine.
439Phosphoserine.
444Phosphothreonine.
455Phosphoserine.
Location(AA) Modifications Resource
184Phosphothreonine (by autocatalysis)(Probable).Swiss-Prot 53.0
184Phosphothreonine (MAP3K7)Phospho.ELM 6.0
187Phosphothreonine (by autocatalysis)(Probable).Swiss-Prot 53.0
187Phosphothreonine (MAP3K7)Phospho.ELM 6.0
192Phosphoserine (by autocatalysis)(Probable).Swiss-Prot 53.0
192Phosphoserine (MAP3K7)Phospho.ELM 6.0
439Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
5Phosphoserine(IKK)HMM predict
11Phosphoserine(CK1)HMM predict
12Phosphoserine(CK1)HMM predict
13O-linkedHMM predict
14Phosphoserine(IKK)HMM predict
33SulfotyrosineHMM predict
33Phosphotyrosine(EGFR)HMM predict
33Phosphotyrosine(Syk)HMM predict
245N-linkedHMM predict
268Phosphoserine(IKK)HMM predict
272Phosphoserine(ATM)HMM predict
304Phosphotyrosine(Syk)HMM predict
310O-linkedHMM predict
312Phosphoserine(IKK)HMM predict
326N-linkedHMM predict
329N-linkedHMM predict
334N-linkedHMM predict
342N-linkedHMM predict
367Phosphoserine(PKG)HMM predict
374O-linkedHMM predict
374Phosphoserine(CK1)HMM predict
415Phosphothreonine(PKA)HMM predict
439Phosphoserine(PKG)HMM predict
439Phosphoserine(PKA)HMM predict
454O-linkedHMM predict
457O-linkedHMM predict
458Phosphoserine(CK1)HMM predict
459Phosphoserine(CDC2)HMM predict
459PhosphoserineHMM predict
461O-linkedHMM predict
472O-linkedHMM predict
472O-linkedHMM predict
476Phosphothreonine(PKC)HMM predict
490N-linkedHMM predict
494N-linkedHMM predict
578N-linkedHMM predict
580Phosphoserine(CK1)HMM predict
595IsoleucineHMM predict
597Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003188
  • Location:chr6 91282073-91353627
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 91353270 91354342 1072 179
E2F4 SGSE7516 91353494 91354306 812 273
ETS1 JurkatGSE17954 91353049 91354237 1188 16
GABP k562GSE8489 91353675 91356044 2369 1232
H3ac HepG2E 91353539 91354029 490 157
LIN54 G0GSE7516 91353304 91354174 870 112
LIN54 SGSE7516 91353494 91354306 812 273
LIN9 G0GSE7516 91353162 91355009 1847 458
LIN9 SGSE7516 91353204 91354675 1471 312
Oct1 HelaGSE14283 91365686 91365714 28 12073
Oct1 HelaGSE14283 91370882 91370923 41 17275
P300 T30-glioblastomaGSE21026 91352958 91354380 1422 42
PHF8 293TGSE20725 91353005 91354252 1247 1
TAF k562GSE8489 91353745 91355900 2155 1195
p130 QuiescentGSE19898 91353489 91354216 727 225
p130 SenescentGSE19898 91353282 91354551 1269 289
p130 shRbQuiescentGSE19898 91353436 91354384 948 283
p130 shRbSenescentGSE19898 91353417 91354300 883 231
p130 G0GSE7516 91353129 91354554 1425 214
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 91352941 91354223 1282 0
PHF8 HeLaGSE20725 91352995 91354064 1069 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-10a hsa-mir-10a 17 20624982
hsa-miR-10a* hsa-mir-10a 17 20624982
hsa-miR-125b hsa-mir-125b-1 11 20306291
hsa-miR-125b-1* hsa-mir-125b-1 11 20306291
hsa-miR-143 hsa-mir-143 5 20064147
hsa-miR-143* hsa-mir-143 5 20064147
hsa-miR-155 hsa-mir-155 21 20948191
hsa-miR-155* hsa-mir-155 21 20948191
hsa-miR-646 hsa-mir-646 20 20306291
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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