AutismKB 2.0

Annotation Detail for TARS


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Basic Information Top
Gene Symbol:TARS ( MGC9344,ThrRS )
Gene Full Name: threonyl-tRNA synthetase
Band: 5p13.3
Quick LinksEntrez ID:6897; OMIM: 187790; Uniprot ID:SYTC_HUMAN; ENSEMBL ID: ENSG00000113407; HGNC ID: 11572
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
243N6-acetyllysine.
298Phosphotyrosine.
Location(AA) Modifications Resource
222Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin).Swiss-Prot 53.0
Location(AA) Modification Resource
8Phosphoserine(CDK)HMM predict
8Phosphoserine(CDK)HMM predict
8Phosphoserine(CDC2)HMM predict
184Phosphotyrosine(Syk)HMM predict
184Phosphotyrosine(INSR)HMM predict
184SulfotyrosineHMM predict
185SulfotyrosineHMM predict
200Phosphoserine(CK1)HMM predict
246Phosphothreonine(MAPK)HMM predict
280N-linkedHMM predict
333Phosphotyrosine(Jak)HMM predict
497N-linkedHMM predict
572N-linkedHMM predict
705IsoleucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_152295
  • Location:chr5 33476654-33503950
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 33471827 33472054 227 4714
CTCF CD4SISSRdata 33471827 33472054 227 4714
CTCF JurkatGSE12889 33471842 33472044 202 4712
CTCF G2GSE9613 33458837 33459346 509 17563
CTCF G2GSE9613 33471762 33471994 232 4777
H3K4me3 colorectalcancer 33475595 33476443 848 636
H3ac HepG2E 33475595 33476813 1218 451
NRSF mAbJurkat 33471762 33471994 232 4777
Rb QuiescentGSE19898 33476195 33476735 540 190
TAF HelaGSE8489 33471762 33471994 232 4777
TAF HelaGSE8489 33475595 33476729 1134 493
hScc1 BcellGSE12603 33471762 33471994 232 4777
hScc1 CdLSGSE12603 33458802 33459346 544 17581
hScc1 CdLSGSE12603 33471762 33471994 232 4777
hScc1 G2GSE9613 33458730 33459346 616 17617
hScc1 G2GSE9613 33471762 33471994 232 4777
p130 QuiescentGSE19898 33476276 33476730 454 152
p130 shRbSenescentGSE19898 33476275 33476609 334 213
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 33506248 33506549 301 2448
Nanog ESGSE20650 33518212 33518706 494 14509
hScc1 BcellGSE12603 33506352 33506549 197 2500
hScc1 G2GSE9613 33506278 33506549 271 2463
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 33476181 33477351 1170 0
Fos K562GSE19551 33476278 33477282 1004 0
H3K4me3 colorectalcancer 33477388 33478216 828 0
H3ac HepG2E 33477131 33478289 1158 0
Oct4 hESGSE21916 33483903 33484474 571 0
PHF8 293TGSE20725 33475973 33477341 1368 0
PHF8 HeLaGSE20725 33475590 33478039 2449 0
PHF8 Hs68plusFBSGSE20725 33476636 33477740 1104 0
RARA MCF7GSE15244 33475710 33477911 2201 0
Rb SenescentGSE19898 33476197 33477272 1075 0
TAF HelaGSE8489 33477087 33478289 1202 0
TAF k562GSE8489 33477087 33478289 1202 0
p130 SenescentGSE19898 33476051 33477761 1710 0
p130 shRbQuiescentGSE19898 33476192 33477506 1314 0
p130 shRbSenescentGSE19898 33476649 33477426 777 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018