AutismKB 2.0

Annotation Detail for TCF4


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Basic Information Top
Gene Symbol:TCF4 ( E2-2,ITF2,MGC149723,MGC149724,PTHS,SEF2,SEF2-1,SEF2-1A,SEF2-1B,bHLHb19 )
Gene Full Name: transcription factor 4
Band: 18q21.2
Quick LinksEntrez ID:6925; OMIM: 602272; Uniprot ID:ITF2_HUMAN; ENSEMBL ID: ENSG00000196628; HGNC ID: 11634
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
269aaTAD.
372Phosphoserine.
Location(AA) Modifications Resource
54Phosphoserine (CK2 alpha)Phospho.ELM 6.0
55Phosphoserine (CK2 alpha)Phospho.ELM 6.0
56Phosphoserine (CK2 alpha)Phospho.ELM 6.0
Location(AA) Modification Resource
27Phosphoserine(ATM)HMM predict
31Phosphoserine(CDC2)HMM predict
54Phosphoserine(CK1)HMM predict
55Phosphoserine(CK1)HMM predict
56Phosphoserine(CK1)HMM predict
66Phosphoserine(CDC2)HMM predict
90N-linkedHMM predict
140Phosphoserine(CDK)HMM predict
140Phosphoserine(CDC2)HMM predict
183Phosphoserine(ATM)HMM predict
188O-linkedHMM predict
204O-linkedHMM predict
208O-linkedHMM predict
209O-linkedHMM predict
224Phosphoserine(ATM)HMM predict
228Phosphoserine(IKK)HMM predict
230O-linkedHMM predict
238Phosphotyrosine(Abl)HMM predict
244N-linkedHMM predict
253Phosphoserine(IKK)HMM predict
274N-linkedHMM predict
276O-linkedHMM predict
292O-linkedHMM predict
297O-linkedHMM predict
297PhosphothreonineHMM predict
301N-linkedHMM predict
318Phosphoserine(ATM)HMM predict
320Phosphothreonine(PKC)HMM predict
338N-linkedHMM predict
339N-linkedHMM predict
342O-linkedHMM predict
343O-linkedHMM predict
343Phosphoserine(IKK)HMM predict
344N-linkedHMM predict
346O-linkedHMM predict
347O-linkedHMM predict
347Phosphothreonine(CDK)HMM predict
354O-linkedHMM predict
372Phosphoserine(ATM)HMM predict
375Phosphotyrosine(INSR)HMM predict
375Phosphotyrosine(Syk)HMM predict
408O-linkedHMM predict
484Phosphoserine(MAPK)HMM predict
484O-linkedHMM predict
494Phosphotyrosine(Syk)HMM predict
508Phosphoserine(CK1)HMM predict
528PhosphoserineHMM predict
546Phosphoserine(CK2)HMM predict
554Phosphothreonine(MAPK)HMM predict
554Phosphothreonine(CDC2)HMM predict
616Phosphoserine(CK1)HMM predict
649O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003199
  • Location:chr18 51045966-51406440
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
P300 T30-glioblastomaGSE21026 51407209 51408695 1486 1512
PHF8 293TGSE20725 51407839 51408750 911 1854
PHF8 Hs68minusFBSGSE20725 51407796 51408783 987 1849
p130 QuiescentGSE19898 51407925 51408485 560 1765
p130 SenescentGSE19898 51406667 51406993 326 390
p130 SenescentGSE19898 51407980 51408659 679 1879
p130 shRbQuiescentGSE19898 51408070 51408747 677 1968
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog ESGSE20650 51032806 51033244 438 12942
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 51318197 51319652 1455 0
CTCF CD4GSE12889 51052924 51053109 185 0
CTCF CD4GSE12889 51233531 51233904 373 0
CTCF CD4SISSRdata 51052924 51053109 185 0
CTCF CD4SISSRdata 51233531 51233904 373 0
CTCF HelaGSE12889 51052975 51053143 168 0
CTCF JurkatGSE12889 51233542 51233749 207 0
CTCF G2GSE9613 51052666 51053373 707 0
CTCF G2GSE9613 51202470 51203158 688 0
CTCF G2GSE9613 51233454 51233825 371 0
Fos K562GSE19551 51068924 51069262 338 0
Fos K562GSE19551 51224073 51224512 439 0
Fos K562GSE19551 51335185 51335661 476 0
Gata2 K562GSE18868 51204858 51205252 394 0
H3K27me3 colorectalcancer 51403998 51405680 1682 0
Myc K562GSE19551 51233649 51233877 228 0
NFkBII GM12878GSE19485 51083304 51088249 4945 0
NFkBII GM18505GSE19485 51085880 51088219 2339 0
Nanog ESGSE20650 51306657 51307274 617 0
Oct1 H2O2-HelaGSE14283 51224682 51224717 35 0
Oct1 H2O2-HelaGSE14283 51357075 51357112 37 0
Oct1 HelaGSE14283 51082664 51082691 27 0
Oct1 HelaGSE14283 51357075 51357114 39 0
Oct4 hESGSE21916 51170210 51170697 487 0
P300 T0-glioblastomaGSE21026 51045945 51047408 1463 0
P300 T30-glioblastomaGSE21026 51318393 51319341 948 0
RNAII Tamoxifen-MCF7GSE14664 51224677 51224717 40 0
Rb shRbQuiescentGSE19898 51303297 51303516 219 0
STAT1 IFNSISSRdata 51295689 51296019 330 0
Sox2 hESGSE18292 51306915 51307209 294 0
TAF HelaGSE8489 51144530 51144755 225 0
hScc1 BcellGSE12603 51052523 51053373 850 0
hScc1 BcellGSE12603 51161714 51162124 410 0
hScc1 BcellGSE12603 51204172 51204413 241 0
hScc1 BcellGSE12603 51233420 51233931 511 0
hScc1 CdLSGSE12603 51052591 51053410 819 0
hScc1 CdLSGSE12603 51161499 51162124 625 0
hScc1 CdLSGSE12603 51233313 51233999 686 0
hScc1 G2GSE9613 51052591 51053373 782 0
p130 QuiescentGSE19898 51062147 51062545 398 0
p63 keratinocytesGSE17611 51240070 51240987 917 0
p63 keratinocytesGSE17611 51270251 51271135 884 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-155 hsa-mir-155 21 21125666
hsa-miR-155 hsa-mir-155 21 21038317
hsa-miR-155* hsa-mir-155 21 21125666
hsa-miR-155* hsa-mir-155 21 21038317
hsa-miR-203 hsa-mir-203 14 21125666
hsa-miR-203 hsa-mir-203 14 21038317
hsa-miR-23b hsa-mir-23b 9 21125666
hsa-miR-23b hsa-mir-23b 9 21038317
hsa-miR-23b* hsa-mir-23b 9 21125666
hsa-miR-23b* hsa-mir-23b 9 21038317
hsa-miR-29c hsa-mir-29c 1 21125666
hsa-miR-29c hsa-mir-29c 1 21038317
hsa-miR-29c* hsa-mir-29c 1 21125666
hsa-miR-29c* hsa-mir-29c 1 21038317
hsa-miR-369-5p hsa-mir-369 14 21125666
hsa-miR-369-5p hsa-mir-369 14 21038317
hsa-miR-370 hsa-mir-370 14 21125666
hsa-miR-370 hsa-mir-370 14 21038317
hsa-miR-450a hsa-mir-450a-1 X 21125666
hsa-miR-450a hsa-mir-450a-2 X 21125666
hsa-miR-450a hsa-mir-450a-1 X 21038317
hsa-miR-450a hsa-mir-450a-2 X 21038317
hsa-miR-542-5p hsa-mir-542 X 21125666
hsa-miR-542-5p hsa-mir-542 X 21038317
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
12184 EST chr18 51270761 51301169 30408 mRNA TCF4 chr18 51045966 51406441 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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