AutismKB 2.0

Annotation Detail for TCF7L2


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Basic Information Top
Gene Symbol:TCF7L2 ( TCF-4,TCF4 )
Gene Full Name: transcription factor 7-like 2 (T-cell specific, HMG-box)
Band: 10q25.2-q25.3
Quick LinksEntrez ID:6934; OMIM: 602228; Uniprot ID:TF7L2_HUMAN; ENSEMBL ID: ENSG00000148737; HGNC ID: 11641
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
430Nuclear localization signal (Potential).
Location(AA) Modifications Resource
58Phosphoserine (CK2
59Phosphoserine (CK2
60Phosphoserine (CK2
Location(AA) Modification Resource
31Phosphoserine(CK1)HMM predict
31Phosphoserine(CK2)HMM predict
32Phosphoserine(CK1)HMM predict
34N-linkedHMM predict
35Phosphoserine(CK2)HMM predict
50N-linkedHMM predict
55N-linkedHMM predict
57N-linkedHMM predict
58Phosphoserine(CK2)HMM predict
60Phosphoserine(CK1)HMM predict
60Phosphoserine(ATM)HMM predict
60Phosphoserine(CK2)HMM predict
62Phosphoserine(CK2)HMM predict
74Phosphoserine(PKB)HMM predict
82Phosphoserine(PKG)HMM predict
82Phosphoserine(CK1)HMM predict
96MethyllysineHMM predict
118N-linkedHMM predict
120O-linkedHMM predict
122Phosphoserine(CDC2)HMM predict
177PhosphoserineHMM predict
179Phosphoserine(ATM)HMM predict
179Phosphoserine(CDC2)HMM predict
201Phosphothreonine(MAPK)HMM predict
242Phosphotyrosine(Syk)HMM predict
246O-linkedHMM predict
246Phosphoserine(CDC2)HMM predict
316Phosphothreonine(MAPK)HMM predict
323Phosphoserine(CK2)HMM predict
324Phosphoserine(CK1)HMM predict
324Phosphoserine(IKK)HMM predict
324Phosphoserine(ATM)HMM predict
326Phosphoserine(CK1)HMM predict
330Phosphoserine(CK1)HMM predict
333Phosphoserine(CDK)HMM predict
498O-linkedHMM predict
498Phosphoserine(IKK)HMM predict
505Phosphoserine(IKK)HMM predict
505Phosphoserine(CK1)HMM predict
509Phosphoserine(IKK)HMM predict
509Phosphoserine(CDC2)HMM predict
509Phosphoserine(ATM)HMM predict
513Phosphoserine(CDK)HMM predict
513Phosphoserine(MAPK)HMM predict
519Phosphoserine(CDC2)HMM predict
526Phosphoserine(IKK)HMM predict
587O-linkedHMM predict
588O-linkedHMM predict
588O-linkedHMM predict
593O-linkedHMM predict
595O-linkedHMM predict
595Phosphoserine(CK1)HMM predict
596Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_030756
  • Location:chr10 114700200-114916050
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 114681288 114681331 43 18891
TFAP2C MCF7GSE21234 114693697 114694208 511 6248
hScc1 G2GSE9613 114699668 114700363 695 185
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 114928468 114928902 434 12635
Sox2 hESGSE18292 114928394 114928836 442 12565
hScc1 CdLSGSE12603 114919688 114919971 283 3779
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 114836781 114837806 1025 0
CTCF CD4GSE12889 114858339 114858470 131 0
CTCF CD4GSE12889 114876404 114876614 210 0
CTCF CD4SISSRdata 114858339 114858470 131 0
CTCF CD4SISSRdata 114876404 114876614 210 0
ER Fulvestrant-MCF7GSE14664 114788329 114788363 34 0
Fos K562GSE19551 114836917 114837638 721 0
FoxA1 MCF7MACSdata 114719468 114719625 157 0
Gata2 K562GSE18868 114810189 114811180 991 0
Gata2 K562GSE18868 114813126 114813747 621 0
H3ac HepG2E 114702446 114704113 1667 0
H3ac HepG2E 114807855 114808685 830 0
Myc K562GSE19551 114823409 114823929 520 0
Myc hESGSE17917 114740608 114740978 370 0
Myc hESGSE17917 114900587 114900829 242 0
NFkBII GM12878GSE19485 114730745 114732126 1381 0
Nanog hESGSE18292 114803718 114804242 524 0
Nanog hESGSE18292 114884877 114885711 834 0
Oct1 H2O2-HelaGSE14283 114716633 114716671 38 0
Oct1 H2O2-HelaGSE14283 114733346 114733395 49 0
Oct1 H2O2-HelaGSE14283 114811447 114811490 43 0
Oct1 H2O2-HelaGSE14283 114877434 114877482 48 0
Oct1 HelaGSE14283 114716627 114716674 47 0
Oct1 HelaGSE14283 114733347 114733395 48 0
Oct1 HelaGSE14283 114744579 114744608 29 0
Oct1 HelaGSE14283 114784267 114784308 41 0
Oct1 HelaGSE14283 114797294 114797340 46 0
Oct1 HelaGSE14283 114811447 114811490 43 0
Oct1 HelaGSE14283 114811688 114811719 31 0
Oct1 HelaGSE14283 114845007 114845036 29 0
Oct1 HelaGSE14283 114850833 114850860 27 0
Oct1 HelaGSE14283 114855542 114855577 35 0
Oct1 HelaGSE14283 114877434 114877483 49 0
Oct4 hESGSE21916 114803517 114804274 757 0
P300 T0-glioblastomaGSE21026 114836695 114837803 1108 0
P300 T30-glioblastomaGSE21026 114823068 114824184 1116 0
P300 T30-glioblastomaGSE21026 114836731 114837785 1054 0
P300 T30-glioblastomaGSE21026 114843018 114843775 757 0
PAX3-FKHR Rh4GSE19063 114705369 114706905 1536 0
PAX3-FKHR Rh4GSE19063 114797159 114798723 1564 0
PHF8 293TGSE20725 114700910 114702246 1336 0
RARA MCF7GSE15244 114730691 114730907 216 0
RARG MCF7GSE15244 114719290 114719571 281 0
RARG MCF7GSE15244 114835684 114835992 308 0
RUNX JurkatGSE17954 114714532 114714570 38 0
Rb GrowingGSE19898 114823709 114823903 194 0
Rb QuiescentGSE19898 114809156 114809385 229 0
Rb shRbQuiescentGSE19898 114910811 114911142 331 0
STAT1 HeLaGSE12783 114713176 114714379 1203 0
STAT1 IFNSISSRdata 114713314 114714347 1033 0
Sox2 hESGSE18292 114803780 114804237 457 0
TFAP2C MCF7GSE21234 114741396 114742444 1048 0
USF1 HepG2E 114753219 114754391 1172 0
USF1 HepG2E 114768624 114771484 2860 0
USF2 HepG2E 114768979 114770188 1209 0
hScc1 BcellGSE12603 114756459 114756750 291 0
hScc1 CdLSGSE12603 114731162 114731492 330 0
hScc1 CdLSGSE12603 114876172 114876452 280 0
hScc1 G2GSE9613 114700866 114701316 450 0
p130 QuiescentGSE19898 114823479 114823770 291 0
p130 QuiescentGSE19898 114896125 114896476 351 0
p130 SenescentGSE19898 114786979 114787261 282 0
p130 SenescentGSE19898 114823374 114823682 308 0
p130 shRbQuiescentGSE19898 114701513 114702015 502 0
p63 keratinocytesGSE17611 114817169 114817988 819 0
p63 keratinocytesGSE17611 114848838 114849865 1027 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-122 hsa-mir-122 18 21059207
hsa-miR-122 hsa-mir-122 18 21059207
hsa-miR-122* hsa-mir-122 18 21059207
hsa-miR-122* hsa-mir-122 18 21059207
hsa-miR-125a-3p hsa-mir-125a 19 20937217
hsa-miR-125a-3p hsa-mir-125a 19 20937217
hsa-miR-125a-5p hsa-mir-125a 19 20937217
hsa-miR-125a-5p hsa-mir-125a 19 20937217
hsa-miR-150 hsa-mir-150 19 20937217
hsa-miR-150 hsa-mir-150 19 20937217
hsa-miR-150* hsa-mir-150 19 20937217
hsa-miR-150* hsa-mir-150 19 20937217
hsa-miR-200b hsa-mir-200b 1 21059207
hsa-miR-200b hsa-mir-200b 1 21059207
hsa-miR-200b* hsa-mir-200b 1 21059207
hsa-miR-200b* hsa-mir-200b 1 21059207
hsa-miR-200c hsa-mir-200c 12 21059207
hsa-miR-200c hsa-mir-200c 12 21059207
hsa-miR-200c* hsa-mir-200c 12 21059207
hsa-miR-200c* hsa-mir-200c 12 21059207
hsa-miR-205 hsa-mir-205 1 21059207
hsa-miR-205 hsa-mir-205 1 21059207
hsa-miR-302a hsa-mir-302a 4 21059207
hsa-miR-302a hsa-mir-302a 4 21059207
hsa-miR-302a* hsa-mir-302a 4 21059207
hsa-miR-302a* hsa-mir-302a 4 21059207
hsa-miR-302b hsa-mir-302b 4 21059207
hsa-miR-302b hsa-mir-302b 4 21059207
hsa-miR-302b* hsa-mir-302b 4 21059207
hsa-miR-302b* hsa-mir-302b 4 21059207
hsa-miR-302c hsa-mir-302c 4 21059207
hsa-miR-302c hsa-mir-302c 4 21059207
hsa-miR-302c* hsa-mir-302c 4 21059207
hsa-miR-302c* hsa-mir-302c 4 21059207
hsa-miR-302d hsa-mir-302d 4 21059207
hsa-miR-302d hsa-mir-302d 4 21059207
hsa-miR-302d* hsa-mir-302d 4 21059207
hsa-miR-302d* hsa-mir-302d 4 21059207
hsa-miR-302f hsa-mir-302f 0 21059207
hsa-miR-302f hsa-mir-302f 0 21059207
hsa-miR-375 hsa-mir-375 2 21059207
hsa-miR-375 hsa-mir-375 2 21059207
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
3686 mRNA TCF7L2 chr10 114700200 114916058 308 EST chr10 114700198 114701624Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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