AutismKB 2.0

Annotation Detail for TDO2


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Basic Information Top
Gene Symbol:TDO2 ( TDO,TPH2,TRPO )
Gene Full Name: tryptophan 2,3-dioxygenase
Band: 4q32.1
Quick LinksEntrez ID:6999; OMIM: 191070; Uniprot ID:T23O_HUMAN; ENSEMBL ID: ENSG00000151790; HGNC ID: 11708
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
155Phosphoserine.
Location(AA) Modifications Resource
146PhosphotyrosinePhospho.ELM 6.0
155Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
28Phosphoserine(IKK)HMM predict
28Phosphoserine(CK1)HMM predict
146Phosphotyrosine(Syk)HMM predict
146Phosphotyrosine(INSR)HMM predict
148Phosphoserine(ATM)HMM predict
148Phosphoserine(CDC2)HMM predict
229N-linkedHMM predict
247Phosphoserine(CK1)HMM predict
285Phosphoserine(PKG)HMM predict
285Phosphoserine(PKA)HMM predict
342Phosphothreonine(PKC)HMM predict
382N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005651
  • Location:chr4 157044296-157060999
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
P300 T0-glioblastomaGSE21026 157040705 157041689 984 3100
P300 T30-glioblastomaGSE21026 157040602 157041490 888 3251
TFAP2C MCF7GSE21234 157031745 157031986 241 12431
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
P300 T0-glioblastomaGSE21026 157047443 157048174 731 0
P300 T30-glioblastomaGSE21026 157047105 157048159 1054 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018