AutismKB 2.0

Annotation Detail for TEC


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Basic Information Top
Gene Symbol:TEC ( MGC126760,MGC126762,PSCTK4 )
Gene Full Name: tec protein tyrosine kinase
Band: 4p12-p11
Quick LinksEntrez ID:7006; OMIM: 600583; Uniprot ID:TEC_HUMAN; ENSEMBL ID: ENSG00000135605; HGNC ID: 11719
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
206Phosphotyrosine; by autocatalysis.
228Phosphotyrosine.
275Phosphoserine.
519Phosphotyrosine; by autocatalysis.
Location(AA) Modifications Resource
206Phosphotyrosine (Tec;BTK;ITK)Phospho.ELM 6.0
519Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
95Phosphoserine(CDK)HMM predict
163Phosphothreonine(PKC)HMM predict
163Phosphothreonine(CDK)HMM predict
180Phosphoserine(CK1)HMM predict
228Phosphotyrosine(INSR)HMM predict
228Phosphotyrosine(EGFR)HMM predict
228Phosphotyrosine(Jak)HMM predict
235Phosphothreonine(PKC)HMM predict
253N-linkedHMM predict
306O-linkedHMM predict
308Phosphoserine(CDC2)HMM predict
313Phosphotyrosine(Syk)HMM predict
366N-linkedHMM predict
439Phosphotyrosine(Jak)HMM predict
439Phosphotyrosine(EGFR)HMM predict
449S-palmitoylHMM predict
521Phosphoserine(CDC2)HMM predict
538N-linkedHMM predict
544Phosphoserine(PKB)HMM predict
544Phosphoserine(IKK)HMM predict
572Phosphotyrosine(Syk)HMM predict
595Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003215
  • Location:chr4 47832557-47966570
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 47972099 47972311 212 5635
CTCF CD4SISSRdata 47972099 47972311 212 5635
KLF4 hESGSE17917 47966700 47967144 444 352
Myc hESGSE17917 47966766 47967145 379 385
Nanog ESGSE20650 47982300 47983061 761 16110
PHF8 HeLaGSE20725 47966058 47967446 1388 182
Sox2 hESGSE18292 47972136 47972313 177 5654
Stat6 IL-4-hr1GSE17850 47967002 47967915 913 888
TAF HelaGSE8489 47986406 47986627 221 19946
TFAP2C MCF7GSE21234 47966691 47967368 677 459
hScc1 BcellGSE12603 47966105 47967136 1031 50
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 47858963 47859466 503 0
CTCF G2GSE9613 47832528 47832893 365 0
CTCF G2GSE9613 47837543 47838191 648 0
CTCF G2GSE9613 47897059 47897264 205 0
CTCF G2GSE9613 47898269 47898565 296 0
CTCF G2GSE9613 47904757 47904936 179 0
CTCF G2GSE9613 47922261 47922554 293 0
CTCF G2GSE9613 47932193 47932405 212 0
CTCF G2GSE9613 47937049 47937274 225 0
CTCF G2GSE9613 47950974 47951295 321 0
CTCF G2GSE9613 47965928 47967171 1243 0
ER E2-MCF7GSE14664 47843276 47843311 35 0
ER E2-MCF7GSE14664 47902857 47902952 95 0
ER Fulvestrant-MCF7GSE14664 47843277 47843312 35 0
Fos K562GSE19551 47925606 47926241 635 0
Fos K562GSE19551 47951892 47952499 607 0
Gata2 K562GSE18868 47884527 47885087 560 0
Gata2 K562GSE18868 47900449 47901174 725 0
Myc K562GSE19551 47884555 47884897 342 0
Myc K562GSE19551 47900538 47901298 760 0
NFkBII GM12878GSE19485 47850090 47851481 1391 0
NFkBII GM12892GSE19485 47869879 47871326 1447 0
Oct1 H2O2-HelaGSE14283 47939616 47939656 40 0
Oct1 H2O2-HelaGSE14283 47939765 47939801 36 0
Oct1 HelaGSE14283 47843274 47843309 35 0
Oct1 HelaGSE14283 47908602 47908636 34 0
Oct1 HelaGSE14283 47915375 47915402 27 0
Oct1 HelaGSE14283 47939598 47939655 57 0
Oct1 HelaGSE14283 47939769 47939801 32 0
Oct1 HelaGSE14283 47948520 47948552 32 0
Oct1 HelaGSE14283 47951994 47952054 60 0
Oct1 HelaGSE14283 47952549 47952595 46 0
P300 T30-glioblastomaGSE21026 47858755 47859627 872 0
RNAII Tamoxifen-MCF7GSE14664 47863904 47863972 68 0
STAT1 HeLaGSE12782 47923929 47925086 1157 0
STAT1 HeLaGSE12783 47924068 47925052 984 0
STAT1 IFNSISSRdata 47924266 47924915 649 0
TFAP2C MCF7GSE21234 47965930 47966427 497 0
hScc1 G2GSE9613 47965892 47966958 1066 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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