Annotation Detail for TERT
Basic Information Top
| Gene Symbol: | TERT ( EST2,TCS1,TP2,TRT,hEST2 ) |
|---|---|
| Gene Full Name: | telomerase reverse transcriptase |
| Band: | 5p15.33 |
| Quick Links | Entrez ID:7015; OMIM: 187270; Uniprot ID:TERT_HUMAN; ENSEMBL ID: ENSG00000164362; HGNC ID: 11730 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 707 | Phosphotyrosine; by SRC-type Tyr-kinases. | |
| 1113 | Phosphothreonine. | |
| 1125 | Phosphoserine. | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 227 | Phosphoserine (PKB | |
| 707 | Phosphotyrosine (Src) | Phospho.ELM 6.0 |
| 797 | Phosphoserine | Phospho.ELM 6.0 |
| 824 | Phosphoserine (PKB | |
| 1113 | Phosphothreonine. | Swiss-Prot 53.0 |
| 1113 | Phosphothreonine | Phospho.ELM 6.0 |
| 1125 | Phosphoserine. | Swiss-Prot 53.0 |
| 1125 | Phosphoserine | Phospho.ELM 6.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 231 | Phosphoserine(IKK) | HMM predict |
| 274 | Phosphoserine(CDC2) | HMM predict |
| 284 | Phosphoserine(CK1) | HMM predict |
| 292 | O-linked | HMM predict |
| 309 | O-linked | HMM predict |
| 310 | Phosphothreonine(PKC) | HMM predict |
| 311 | O-linked | HMM predict |
| 319 | O-linked | HMM predict |
| 325 | Phosphotyrosine(Abl) | HMM predict |
| 333 | Phosphotyrosine(Jak) | HMM predict |
| 375 | Phosphothreonine(CDK) | HMM predict |
| 375 | Phosphothreonine(CDC2) | HMM predict |
| 420 | Phosphothreonine(MAPK) | HMM predict |
| 456 | Phosphoserine(CK1) | HMM predict |
| 504 | Phosphoserine(PKG) | HMM predict |
| 523 | Phosphoserine(CDC2) | HMM predict |
| 644 | Phosphothreonine(PKC) | HMM predict |
| 655 | Phosphothreonine(PKC) | HMM predict |
| 797 | Phosphoserine(CK1) | HMM predict |
| 824 | Phosphoserine(PKB) | HMM predict |
| 1028 | N-linked | HMM predict |
| 1041 | Phosphoserine(IKK) | HMM predict |
| 1088 | Phosphothreonine(PKA) | HMM predict |
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq| Micro RNA Name | Stem Loop Name | The chromosome that miRNA located | Publication |
|---|---|---|---|
| hsa-miR-10b | hsa-mir-10b | 2 | 21241449 |
| hsa-miR-10b* | hsa-mir-10b | 2 | 21241449 |
| hsa-miR-23b | hsa-mir-23b | 9 | 21241449 |
| hsa-miR-23b* | hsa-mir-23b | 9 | 21241449 |
| hsa-miR-429 | hsa-mir-429 | 1 | 21233447 |
| ID in Tarbase | Data Type | Support Type | miRNA | Gene | Direct Support | Publication |
|---|---|---|---|---|---|---|
| 458 | mRNA repression | TRUE | miR-138 | TERT | Luciferase assay | 18201269 |
| Ensembl | Protein Type | Differentially expressed in | Pathology or Event | Mis Regulation | Gene Expression | Tumour Involvement |
| ENSG00000164362 | endothelium | anaplastic thyroid carcinoma (ATC) | down regulated | "epithelium, lymphocyte" | "malignant tumour, leukaemia, non-Hodgkin's, sarcoma" |