Annotation Detail for TFAM

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Basic Information Top

Gene Symbol:	TFAM ( MtTF1,TCF6,TCF6L1,TCF6L2,TCF6L3,mtTFA )
Gene Full Name:	transcription factor A, mitochondrial
Band:	10q21.1
Quick Links	Entrez ID:7019; OMIM: 600438; Uniprot ID:TFAM_HUMAN; ENSEMBL ID: ENSG00000108064; HGNC ID: 11741
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:1 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:9 results

Location(AA)	Modification
193	Phosphoserine.

Location(AA)	Modification	Resource
25	S-palmitoyl	HMM predict
99	Phosphotyrosine(EGFR)	HMM predict
99	Phosphotyrosine(INSR)	HMM predict
99	Phosphotyrosine(Syk)	HMM predict
144	Phosphothreonine(PKC)	HMM predict
160	Phosphoserine	HMM predict
184	Phosphothreonine(PKC)	HMM predict
200	Phosphotyrosine(INSR)	HMM predict
217	Phosphoserine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_003201
Location:chr10 59815181-59825901
strand:+

Upstream the gene:5 results
Downstream the gene:4 results
Inside the gene:6 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3ac	HepG2	E	59814246	59814773	527	672
Myc	hES	GSE17917	59814725	59815073	348	283
PHF8	293T	GSE20725	59814397	59815922	1525	22
hScc1	Bcell	GSE12603	59814737	59815473	736	77
hScc1	CdLS	GSE12603	59814518	59815675	1157	85

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Oct1	H2O2-Hela	GSE14283	59841194	59841240	46	15316
Oct1	Hela	GSE14283	59844752	59844799	47	18874
TFAP2C	MCF7	GSE21234	59842369	59842862	493	16714
hScc1	G2	GSE9613	59844169	59844762	593	18564

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	59814835	59815541	706	0
CTCF	CD4	SISSRdata	59814835	59815541	706	0
ETS1	Jurkat	GSE17954	59814763	59815850	1087	0
H3ac	HepG2	E	59815219	59815949	730	0
H3ac	HepG2	E	59817072	59817383	311	0
PHF8	HeLa	GSE20725	59814670	59815839	1169	0

Validated miRNA targets

miR Walk:2 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-21	hsa-mir-21	17	18997871
hsa-miR-21*	hsa-mir-21	17	18997871

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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