Annotation Detail for TFAP4

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Basic Information Top

Gene Symbol:	TFAP4 ( AP-4,bHLHc41 )
Gene Full Name:	transcription factor AP-4 (activating enhancer binding protein 4)
Band:	16p13.3
Quick Links	Entrez ID:7023; OMIM: 600743; Uniprot ID:TFAP4_HUMAN; ENSEMBL ID: ENSG00000090447; HGNC ID: 11745
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
124	Phosphoserine.
139	Phosphoserine.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	4278479	4278791	312	15625
CTCF	CD4	SISSRdata	4278479	4278791	312	15625
CTCF	Jurkat	GSE12889	4278411	4278718	307	15554
CTCF	G2	GSE9613	4262718	4263459	741	78
CTCF	G2	GSE9613	4263802	4264126	324	954
CTCF	G2	GSE9613	4278243	4278793	550	15508
FoxA1	MCF7	MACSdata	4280396	4280543	147	17459
H3K4me3	colorectal	cancer	4263014	4263459	445	226
Oct4	hES	GSE17917	4278567	4278837	270	15692
Rb	Quiescent	GSE19898	4262905	4263139	234	12
Rb	Senescent	GSE19898	4262618	4263458	840	28
hScc1	Bcell	GSE12603	4262858	4263502	644	170
hScc1	Bcell	GSE12603	4278123	4278793	670	15448
hScc1	CdLS	GSE12603	4278123	4278793	670	15448
p130	Quiescent	GSE19898	4262897	4263152	255	14
p130	Senescent	GSE19898	4262906	4263140	234	13
p130	shRbQuiescent	GSE19898	4262896	4263496	600	186
p130	shRbSenescent	GSE19898	4262902	4263154	252	18

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	4243980	4244492	512	2953
CTCF	CD4	SISSRdata	4243980	4244492	512	2953
CTCF	G2	GSE9613	4231700	4232488	788	15095
CTCF	G2	GSE9613	4243582	4244256	674	3270
ER	E2-MCF7	GSE14664	4232176	4232208	32	14997
Myc	K562	GSE19551	4234021	4234794	773	12781
Oct1	Hela	GSE14283	4232173	4232204	31	15000
Oct1	Hela	GSE14283	4239286	4239322	36	7885
PHF8	293T	GSE20725	4243176	4243930	754	3636
PHF8	Hs68plusFBS	GSE20725	4242896	4244393	1497	3544
RNAII	Tamoxifen-MCF7	GSE14664	4243738	4243832	94	3404
TFAP2C	MCF7	GSE21234	4243276	4244387	1111	3357
hScc1	Bcell	GSE12603	4244008	4244256	248	3057
hScc1	CdLS	GSE12603	4243428	4244256	828	3347

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	CD4	GSE12889	4251666	4251884	218
CTCF	CD4	SISSRdata	4251666	4251884	218
CTCF	Jurkat	GSE12889	4251653	4251917	264
CTCF	G2	GSE9613	4251557	4252863	1306
CTCF	G2	GSE9613	4261701	4262221	520
ER	MCF7	GSE19013	4250153	4250936	783
ETS1	Jurkat	GSE17954	4261119	4262632	1513
Fos	K562	GSE19551	4256320	4256818	498
Myc	hES	GSE17917	4261780	4262007	227
Nanog	hES	GSE18292	4256452	4256708	256
PHF8	293T	GSE20725	4261061	4263277	2216
PHF8	Hs68plusFBS	GSE20725	4261079	4262560	1481
Rb	Growing	GSE19898	4262695	4262899	204
Rb	shRbSenescence	GSE19898	4262779	4263120	341
TFAP2C	MCF7	GSE21234	4260788	4262050	1262
VDR	GM10861-Unstim	GSE22484	4260888	4264419	3531
VDR	GM10861-stim	GSE22484	4260662	4264505	3843
hScc1	Bcell	GSE12603	4251658	4251934	276
hScc1	Bcell	GSE12603	4260849	4261324	475
hScc1	Bcell	GSE12603	4261801	4262294	493

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-1	hsa-mir-1-2	18	15685193
hsa-miR-1	hsa-mir-1-1	20	15685193
hsa-miR-124	hsa-mir-124-1	8	15685193
hsa-miR-124	hsa-mir-124-2	8	15685193
hsa-miR-124	hsa-mir-124-3	20	15685193
hsa-miR-373	hsa-mir-373	19	15685193
hsa-miR-373*	hsa-mir-373	19	15685193

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
681	Unknown	MicroArray	miR-373	TFAP4	n_a	15685193
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000090447		n_a	n_a	n_a	lymphocyte	"benign tumour, malignant tumour, carcinoma"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018