AutismKB 2.0

Annotation Detail for TG


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Basic Information Top
Gene Symbol:TG ( AITD3,TGN )
Gene Full Name: thyroglobulin
Band: 8q24.22
Quick LinksEntrez ID:7038; OMIM: 188450; Uniprot ID:THYG_HUMAN; ENSEMBL ID: ENSG00000042832; HGNC ID: 11764
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
24Sulfotyrosine; alternate (By similarity).
24Thyroxine; alternate.
76N-linked (GlcNAc...).
198N-linked (GlcNAc...).
484N-linked (GlcNAc...).
529N-linked (GlcNAc...).
748N-linked (GlcNAc...).
816N-linked (GlcNAc...).
947N-linked (GlcNAc...).
1220N-linked (GlcNAc...).
1310Thyroxine.
1348N-linked (GlcNAc...) (Probable).
1349N-linked (GlcNAc...).
1365N-linked (GlcNAc...).
1716N-linked (GlcNAc...).
1774N-linked (GlcNAc...).
2013N-linked (GlcNAc...).
2250N-linked (GlcNAc...).
2295N-linked (GlcNAc...).
2573Thyroxine.
2582N-linked (GlcNAc...).
2587Thyroxine.
2749O-linked (Xyl...) (chondroitin sulfate).
2766Triiodothyronine.
Location(AA) Modifications Resource
24Sulfotyrosine.Swiss-Prot 53.0
24Thyroxine.Swiss-Prot 53.0
76N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
110N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
198N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
484N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
496N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
529N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
748N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
816N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
947N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1220N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1310Thyroxine.Swiss-Prot 53.0
1348N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1349N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1365N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1716N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1774N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1869N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2013N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2122N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2250N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2295N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2573Thyroxine.Swiss-Prot 53.0
2582N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2587Thyroxine.Swiss-Prot 53.0
2766Triiodothyronine.Swiss-Prot 53.0
Location(AA) Modification Resource
76N-linkedHMM predict
110N-linkedHMM predict
123PhosphoserineHMM predict
126Phosphotyrosine(INSR)HMM predict
126Phosphotyrosine(Syk)HMM predict
198N-linkedHMM predict
258Phosphotyrosine(Syk)HMM predict
297S-palmitoylHMM predict
366Phosphoserine(CK1)HMM predict
384Phosphoserine(ATM)HMM predict
390Phosphoserine(CK1)HMM predict
391Phosphoserine(CDC2)HMM predict
391Phosphoserine(CDK)HMM predict
496N-linkedHMM predict
528O-linkedHMM predict
529N-linkedHMM predict
530Phosphoserine(CK1)HMM predict
531O-linkedHMM predict
534Phosphothreonine(CDC2)HMM predict
611Phosphothreonine(CDC2)HMM predict
611Phosphothreonine(MAPK)HMM predict
611Phosphothreonine(CDK)HMM predict
626Phosphotyrosine(SRC)HMM predict
638S-palmitoylHMM predict
671Phosphoserine(PKA)HMM predict
675Phosphoserine(ATM)HMM predict
680O-linkedHMM predict
748N-linkedHMM predict
798Phosphothreonine(MAPK)HMM predict
837Phosphoserine(ATM)HMM predict
916O-linkedHMM predict
947N-linkedHMM predict
1001Phosphothreonine(PKC)HMM predict
1011Phosphoserine(CAMK2)HMM predict
1011Phosphoserine(CDC2)HMM predict
1011Phosphoserine(PKB)HMM predict
1094Phosphoserine(ATM)HMM predict
1097N-linkedHMM predict
1139Phosphoserine(CK2)HMM predict
1141O-linkedHMM predict
1147Phosphoserine(IKK)HMM predict
1273Phosphoserine(PKG)HMM predict
1348N-linkedHMM predict
1349N-linkedHMM predict
1365N-linkedHMM predict
1421Phosphothreonine(PKC)HMM predict
1445Phosphotyrosine(SRC)HMM predict
1467Phosphotyrosine(SRC)HMM predict
1468Phosphoserine(CK2)HMM predict
1468Phosphoserine(CK2)HMM predict
1468Phosphoserine(ATM)HMM predict
1468PhosphoserineHMM predict
1493S-palmitoylHMM predict
1563Phosphoserine(IKK)HMM predict
1620O-linkedHMM predict
1716N-linkedHMM predict
1754Phosphoserine(CDC2)HMM predict
1754Phosphoserine(MAPK)HMM predict
1774N-linkedHMM predict
1782Phosphotyrosine(Abl)HMM predict
1839Phosphothreonine(PKA)HMM predict
1845Phosphoserine(CDC2)HMM predict
1845Phosphoserine(IKK)HMM predict
1869N-linkedHMM predict
1874Phosphoserine(CK1)HMM predict
1874Phosphoserine(ATM)HMM predict
2122N-linkedHMM predict
2135Phosphoserine(ATM)HMM predict
2162Phosphoserine(IKK)HMM predict
2233Phosphotyrosine(Abl)HMM predict
2250N-linkedHMM predict
2272O-linkedHMM predict
2272Phosphoserine(PKA)HMM predict
2274O-linkedHMM predict
2274Phosphoserine(CDC2)HMM predict
2274Phosphoserine(MAPK)HMM predict
2274Phosphoserine(CDK)HMM predict
2283Phosphotyrosine(Syk)HMM predict
2311Phosphoserine(CK1)HMM predict
2381Phosphoserine(PKA)HMM predict
2381Phosphoserine(PKA)HMM predict
2381Phosphoserine(PKG)HMM predict
2381Phosphoserine(IKK)HMM predict
2381Phosphoserine(PKA)HMM predict
2419Phosphoserine(MAPK)HMM predict
2447PhosphoserineHMM predict
2511Phosphoserine(ATM)HMM predict
2533Phosphothreonine(PKC)HMM predict
2534Phosphoserine(PKG)HMM predict
2535Phosphoserine(PKB)HMM predict
2569Phosphoserine(CK2)HMM predict
2573Phosphotyrosine(INSR)HMM predict
2573Phosphotyrosine(Syk)HMM predict
2582N-linkedHMM predict
2611Phosphotyrosine(Jak)HMM predict
2683O-linkedHMM predict
2683Phosphothreonine(CDC2)HMM predict
2697Phosphotyrosine(EGFR)HMM predict
2697Phosphotyrosine(INSR)HMM predict
2697Phosphotyrosine(Syk)HMM predict
2740Phosphoserine(CK1)HMM predict
2740Phosphoserine(CK2)HMM predict
2740Phosphoserine(CK2)HMM predict
2757Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003235
  • Location:chr8 133948386-134216322
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Breast-CancerGSE22609 134220756 134221462 706 4787
FOXA1 MCF7GSE15244 134220819 134221214 395 4694
RARA MCF7GSE15244 134220492 134221411 919 4629
RARG MCF7GSE15244 134220417 134221333 916 4553
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 133956969 133957196 227 0
CTCF CD4GSE12889 134201847 134202065 218 0
CTCF CD4SISSRdata 133956969 133957196 227 0
CTCF CD4SISSRdata 134201847 134202065 218 0
FOXA1 DLD1GSE12801 134008064 134008914 850 0
FOXA1 MCF7GSE15244 133949496 133949635 139 0
FOXA1 MCF7GSE15244 133979386 133980777 1391 0
FOXA1 MCF7GSE15244 133999592 134000013 421 0
FOXA1 MCF7GSE15244 134114507 134114687 180 0
FOXA1 MCF7GSE15244 134193202 134194505 1303 0
FoxA1 MCF7MACSdata 133980416 133980699 283 0
FoxA1 MCF7MACSdata 134193576 134193894 318 0
GATA3 MCF7GSE15244 134114470 134114721 251 0
GATA3 MCF7GSE15244 134185818 134186589 771 0
NRSF pAbJurkat 133981783 133982263 480 0
NRSF pAbJurkat 134204598 134204741 143 0
P300 T0-glioblastomaGSE21026 134193355 134194347 992 0
P300 T30-glioblastomaGSE21026 133980291 133981402 1111 0
P300 T30-glioblastomaGSE21026 134081411 134082133 722 0
P300 T30-glioblastomaGSE21026 134193367 134194197 830 0
P300 T30-glioblastomaGSE21026 134211460 134213048 1588 0
RARA MCF7GSE15244 133980134 133982012 1878 0
RARA MCF7GSE15244 133999632 134000013 381 0
RARA MCF7GSE15244 134081650 134082232 582 0
RARA MCF7GSE15244 134114177 134115315 1138 0
RARG MCF7GSE15244 133975037 133975293 256 0
RARG MCF7GSE15244 133999493 134000013 520 0
RARG MCF7GSE15244 134090310 134090752 442 0
RARG MCF7GSE15244 134108551 134108736 185 0
RARG MCF7GSE15244 134114470 134115315 845 0
Rb QuiescentGSE19898 134117678 134117831 153 0
STAT1 HeLaGSE12782 134000890 134002175 1285 0
STAT1 HeLaGSE12783 134000924 134002175 1251 0
Sox2 hESGSE18292 133956986 133957336 350 0
TFAP2C MCF7GSE21234 133980165 133980891 726 0
TFAP2C MCF7GSE21234 134114566 134115131 565 0
hScc1 BcellGSE12603 133956617 133957520 903 0
hScc1 BcellGSE12603 134191308 134191919 611 0
hScc1 CdLSGSE12603 133956905 133957310 405 0
hScc1 CdLSGSE12603 134094240 134094522 282 0
hScc1 G2GSE9613 133956905 133958012 1107 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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