Annotation Detail for THBS1

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Basic Information Top

Gene Symbol:	THBS1 ( THBS,THBS-1,TSP,TSP-1,TSP1 )
Gene Full Name:	thrombospondin 1
Band:	15q14
Quick Links	Entrez ID:7057; OMIM: 188060; Uniprot ID:TSP1_HUMAN; ENSEMBL ID: ENSG00000137801; HGNC ID: 11785
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
248	N-linked (GlcNAc...) (Probable).
360	N-linked (GlcNAc...) (Potential).
385	C-linked (Man).
394	O-linked (Fuc...).
438	C-linked (Man).
441	C-linked (Man).
450	O-linked (Fuc...).
498	C-linked (Man).
507	O-linked (Fuc...).
708	N-linked (GlcNAc...) (Potential).
928	Cell attachment site (Probable).
1067	N-linked (GlcNAc...).

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	37659368	37661602	2234	87
FOXA1	MCF7	GSE15244	37658772	37659806	1034	1283
FOXA1	eGFP	GSE10845	37658772	37659806	1034	1283
Oct1	Hela	GSE14283	37654057	37654084	27	6501
hScc1	Bcell	GSE12603	37659269	37661602	2333	136
hScc1	CdLS	GSE12603	37659138	37660669	1531	668

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	37663236	37663673	437
CTCF	G2	GSE9613	37667552	37667743	191
H3ac	HepG2	E	37660780	37661602	822
Oct1	H2O2-Hela	GSE14283	37666181	37666219	38
Oct1	Hela	GSE14283	37663816	37663860	44
Oct1	Hela	GSE14283	37666178	37666219	41
TFAP2C	MCF7	GSE21234	37668863	37669482	619

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-17	hsa-mir-17	13	16878133
hsa-miR-17*	hsa-mir-17	13	16878133
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	16239240
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040
hsa-miR-92a	hsa-mir-92a-1	13	16878133
hsa-miR-92a	hsa-mir-92a-2	X	16878133

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
604	mRNA repression	TRUE	miR-30a-3p	THBS1	n_a	16239240
902	Unknown	pSILAC	let-7b	THBS1	down 50-25%	18668040
930	Unknown	pSILAC	LNA_let-7b	THBS1	up <25%	18668040
1205	Unknown	pSILAC	miR-1	THBS1	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000137801		n_a	n_a	n_a	"squamous cell, leukocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, sarcoma"
ENSG00000137801		n_a	n_a	n_a	"squamous cell, leukocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, sarcoma"
ENSG00000137801		n_a	n_a	n_a	"squamous cell, leukocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, sarcoma"
ENSG00000137801		n_a	n_a	n_a	"squamous cell, leukocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, sarcoma"

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
8659	mRNA	THBS1	chr15	37660571	37676959	179	EST		chr15	37673080	37673724	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018