AutismKB 2.0

Annotation Detail for TJP1


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Basic Information Top
Gene Symbol:TJP1 ( DKFZp686M05161,MGC133289,ZO-1 )
Gene Full Name: tight junction protein 1 (zona occludens 1)
Band: 15q13.1
Quick LinksEntrez ID:7082; OMIM: 601009; Uniprot ID:ZO1_HUMAN; ENSEMBL ID: ENSG00000104067; HGNC ID: 11827
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
125Phosphoserine.
131Phosphoserine.
132Phosphotyrosine.
166Phosphoserine.
168Phosphoserine.
175Phosphoserine (By similarity).
178Phosphoserine (By similarity).
179Phosphoserine (By similarity).
275Phosphoserine.
277Phosphoserine.
280Phosphoserine.
284Phosphoserine (By similarity).
297Phosphoserine (By similarity).
300Phosphoserine (By similarity).
329Phosphoserine.
337Phosphoserine.
353Phosphoserine.
354Phosphothreonine.
402Phosphoserine.
617Phosphoserine.
868Phosphothreonine.
912Phosphoserine.
927Phosphoserine.
968Phosphoserine.
1140Phosphotyrosine (By similarity).
1165Phosphotyrosine (By similarity).
1354Phosphotyrosine (By similarity).
1366Phosphoserine.
1545Phosphoserine.
1617Phosphoserine.
1619Phosphoserine.
Location(AA) Modifications Resource
166Phosphoserine.Swiss-Prot 53.0
168Phosphoserine.Swiss-Prot 53.0
175Phosphoserine (By similarity).Swiss-Prot 53.0
275Phosphoserine.Swiss-Prot 53.0
277Phosphoserine.Swiss-Prot 53.0
280Phosphoserine.Swiss-Prot 53.0
284Phosphoserine (By similarity).Swiss-Prot 53.0
297Phosphoserine (By similarity).Swiss-Prot 53.0
300Phosphoserine (By similarity).Swiss-Prot 53.0
337Phosphoserine.Swiss-Prot 53.0
402Phosphoserine.Swiss-Prot 53.0
588PhosphotyrosinePhospho.ELM 6.0
617Phosphoserine (By similarity).Swiss-Prot 53.0
868Phosphothreonine.Swiss-Prot 53.0
1366Phosphoserine.Swiss-Prot 53.0
1435PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
105Phosphothreonine(PKC)HMM predict
125PhosphoserineHMM predict
132Phosphotyrosine(EGFR)HMM predict
132Phosphotyrosine(INSR)HMM predict
132SulfotyrosineHMM predict
168Phosphoserine(CDC2)HMM predict
168Phosphoserine(MAPK)HMM predict
168Phosphoserine(ATM)HMM predict
168PhosphoserineHMM predict
175Phosphoserine(IKK)HMM predict
179Phosphoserine(ATM)HMM predict
188Phosphothreonine(PKA)HMM predict
233N-linkedHMM predict
239N-linkedHMM predict
282N-linkedHMM predict
311Phosphoserine(PKA)HMM predict
313O-linkedHMM predict
313Phosphoserine(PKG)HMM predict
315Phosphoserine(CAMK2)HMM predict
315Phosphoserine(CDC2)HMM predict
315Phosphoserine(IKK)HMM predict
320Phosphoserine(IKK)HMM predict
323Phosphoserine(CK2)HMM predict
335N-linkedHMM predict
337Phosphoserine(CDK)HMM predict
347Phosphoserine(CK1)HMM predict
354Phosphothreonine(CDC2)HMM predict
354Phosphothreonine(CDK)HMM predict
381O-linkedHMM predict
381Phosphoserine(PKA)HMM predict
381Phosphoserine(IKK)HMM predict
389Phosphotyrosine(Abl)HMM predict
410N-linkedHMM predict
507Phosphotyrosine(EGFR)HMM predict
520Phosphotyrosine(EGFR)HMM predict
628O-linkedHMM predict
633Phosphotyrosine(EGFR)HMM predict
669Phosphotyrosine(SRC)HMM predict
809Phosphothreonine(CK2)HMM predict
810Phosphoserine(CK2)HMM predict
828Phosphoserine(IKK)HMM predict
843Phosphotyrosine(Syk)HMM predict
843SulfotyrosineHMM predict
853Phosphotyrosine(INSR)HMM predict
853Phosphotyrosine(Abl)HMM predict
853SulfotyrosineHMM predict
868Phosphothreonine(CDK)HMM predict
892N-linkedHMM predict
899O-linkedHMM predict
927Phosphoserine(MAPK)HMM predict
931Phosphotyrosine(Abl)HMM predict
933O-linkedHMM predict
933Phosphoserine(CDC2)HMM predict
941O-linkedHMM predict
950N-linkedHMM predict
953N-linkedHMM predict
960O-linkedHMM predict
964O-linkedHMM predict
965O-linkedHMM predict
976Phosphothreonine(MAPK)HMM predict
976Phosphothreonine(CDK)HMM predict
992Phosphoserine(CK1)HMM predict
994Phosphoserine(CK1)HMM predict
1036N-linkedHMM predict
1123Phosphoserine(CK1)HMM predict
1124Phosphoserine(CK1)HMM predict
1128Phosphotyrosine(Jak)HMM predict
1180O-linkedHMM predict
1199Phosphotyrosine(Syk)HMM predict
1230Phosphoserine(ATM)HMM predict
1251Phosphothreonine(CK2)HMM predict
1251PhosphothreonineHMM predict
1286N-linkedHMM predict
1346Phosphotyrosine(INSR)HMM predict
1346SulfotyrosineHMM predict
1354Phosphotyrosine(Jak)HMM predict
1354Phosphotyrosine(Syk)HMM predict
1354PhosphotyrosineHMM predict
1354SulfotyrosineHMM predict
1355Phosphotyrosine(Jak)HMM predict
1355Phosphotyrosine(Syk)HMM predict
1366Phosphoserine(PKA)HMM predict
1389Phosphoserine(ATM)HMM predict
1391N-linkedHMM predict
1394N-linkedHMM predict
1396Phosphoserine(CK1)HMM predict
1400Phosphoserine(CDK)HMM predict
1419Phosphotyrosine(INSR)HMM predict
1419Phosphotyrosine(SRC)HMM predict
1419Phosphotyrosine(Syk)HMM predict
1435Phosphotyrosine(Syk)HMM predict
1439O-linkedHMM predict
1443O-linkedHMM predict
1478Phosphoserine(ATM)HMM predict
1511N-linkedHMM predict
1534Phosphoserine(CDC2)HMM predict
1545Phosphoserine(CDC2)HMM predict
1567Phosphothreonine(CDC2)HMM predict
1569O-linkedHMM predict
1570O-linkedHMM predict
1570Phosphoserine(CDC2)HMM predict
1588Phosphoserine(IKK)HMM predict
1617Phosphoserine(CDC2)HMM predict
1695Phosphoserine(CDC2)HMM predict
1695Phosphoserine(MAPK)HMM predict
1734Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003257
  • Location:chr15 27779650-27901997
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 27902518 27902863 345 693
Myc K562GSE19551 27908730 27909066 336 6901
PHF8 Hs68minusFBSGSE20725 27901393 27903197 1804 298
PHF8 Hs68plusFBSGSE20725 27900882 27903183 2301 35
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 27767129 27767474 345 12349
FoxA1 MCF7MACSdata 27770735 27770924 189 8821
Rb SenescentGSE19898 27777900 27778307 407 1547
TFAP2C MCF7GSE21234 27766582 27767762 1180 12479
hScc1 BcellGSE12603 27761457 27761720 263 18062
p130 QuiescentGSE19898 27770175 27770380 205 9373
p130 QuiescentGSE19898 27777042 27777174 132 2543
p130 QuiescentGSE19898 27778004 27778249 245 1524
p130 shRbSenescentGSE19898 27777890 27778162 272 1625
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 27827471 27827644 173 0
CTCF CD4SISSRdata 27827471 27827644 173 0
CTCF G2GSE9613 27901118 27901948 830 0
FoxA1 MCF7MACSdata 27891487 27892009 522 0
Myc K562GSE19551 27894856 27895336 480 0
NRSF-mono JurkatQuESTdata 27829140 27829419 279 0
Oct1 H2O2-HelaGSE14283 27831254 27831286 32 0
Oct1 H2O2-HelaGSE14283 27864237 27864265 28 0
Oct1 HelaGSE14283 27786312 27786408 96 0
Oct1 HelaGSE14283 27796468 27796522 54 0
Oct1 HelaGSE14283 27831221 27831286 65 0
Oct1 HelaGSE14283 27880142 27880229 87 0
P300 T0-glioblastomaGSE21026 27884302 27885091 789 0
PHF8 293TGSE20725 27901356 27902418 1062 0
PHF8 HeLaGSE20725 27900644 27902757 2113 0
hScc1 BcellGSE12603 27810113 27810375 262 0
hScc1 BcellGSE12603 27901049 27902574 1525 0
p63 keratinocytesGSE17611 27836118 27836911 793 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-212 hsa-mir-212 17 18162065
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
8560 EST chr15 27810757 27811314 557 mRNA TJP1 chr15 27779650 27901998 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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