AutismKB 2.0

Annotation Detail for TLE1


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Basic Information Top
Gene Symbol:TLE1 ( ESG,ESG1,GRG1 )
Gene Full Name: transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Band: 9q21.32
Quick LinksEntrez ID:7088; OMIM: 600189; Uniprot ID:TLE1_HUMAN; ENSEMBL ID: ENSG00000196781; HGNC ID: 11837
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
228Nuclear localization signal (Potential).
239Phosphoserine; by CK2 (Potential).
259Phosphoserine; by CDK1 (Potential).
263Phosphoserine; by CDK1 (Potential).
267Phosphoserine; by CDK1 (Potential).
284Phosphoserine (By similarity).
286Phosphoserine.
Location(AA) Modifications Resource
239Phosphoserine (by CK2) (Potential).Swiss-Prot 53.0
239Phosphoserine (CK2 alpha)Phospho.ELM 6.0
259Phosphoserine (by CDC2) (Potential).Swiss-Prot 53.0
263Phosphoserine (by CDC2) (Potential).Swiss-Prot 53.0
267Phosphoserine (by CDC2) (Potential).Swiss-Prot 53.0
284Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
61SulfotyrosineHMM predict
144Phosphothreonine(MAPK)HMM predict
148O-linkedHMM predict
172Phosphoserine(CK2)HMM predict
172Phosphoserine(CK1)HMM predict
172Phosphoserine(ATM)HMM predict
237Phosphotyrosine(Syk)HMM predict
244Phosphoserine(CK2)HMM predict
258Phosphoserine(CK1)HMM predict
259Phosphoserine(CDC2)HMM predict
259Phosphoserine(MAPK)HMM predict
259PhosphoserineHMM predict
259Phosphoserine(IKK)HMM predict
259Phosphoserine(ATM)HMM predict
263Phosphoserine(CDC2)HMM predict
263Phosphoserine(CDK)HMM predict
263O-linkedHMM predict
263PhosphoserineHMM predict
267Phosphoserine(CDC2)HMM predict
284Phosphoserine(CK2)HMM predict
285Phosphoserine(CK1)HMM predict
286O-linkedHMM predict
286Phosphoserine(IKK)HMM predict
286Phosphoserine(CDC2)HMM predict
289Phosphoserine(IKK)HMM predict
290O-linkedHMM predict
292Phosphoserine(IKK)HMM predict
297O-linkedHMM predict
298Phosphoserine(CK1)HMM predict
305Phosphoserine(CK1)HMM predict
317O-linkedHMM predict
319Phosphothreonine(MAPK)HMM predict
321Phosphothreonine(CDC2)HMM predict
321Phosphothreonine(MAPK)HMM predict
321Phosphothreonine(CDK)HMM predict
324O-linkedHMM predict
328Phosphothreonine(MAPK)HMM predict
332O-linkedHMM predict
334Phosphothreonine(MAPK)HMM predict
360Phosphothreonine(MAPK)HMM predict
386Phosphoserine(MAPK)HMM predict
494N-linkedHMM predict
517N-linkedHMM predict
519Phosphoserine(CDC2)HMM predict
522Phosphoserine(IKK)HMM predict
563Phosphothreonine(MAPK)HMM predict
573O-linkedHMM predict
583Phosphoserine(MAPK)HMM predict
583Phosphoserine(ATM)HMM predict
593S-palmitoylHMM predict
605N-linkedHMM predict
665Phosphotyrosine(Jak)HMM predict
741Phosphoserine(IKK)HMM predict
764Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005077
  • Location:chr9 83388419-83493415
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 83494664 83495621 957 1727
H3K4me3 colorectalcancer 83494714 83495078 364 1481
Oct1 H2O2-HelaGSE14283 83506986 83507034 48 13595
Oct1 HelaGSE14283 83506985 83507038 53 13596
Rb GrowingGSE19898 83494610 83494912 302 1346
Rb QuiescentGSE19898 83494467 83494980 513 1308
TFAP2C MCF7GSE21234 83508189 83508460 271 14909
p130 SenescentGSE19898 83494364 83494923 559 1228
p130 shRbSenescentGSE19898 83494264 83494808 544 1121
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 83467822 83468663 841 0
FOXA1 MCF7GSE15244 83391882 83394073 2191 0
FOXA1 MCF7GSE15244 83438902 83439607 705 0
FOXA1 MCF7GSE15244 83460793 83461554 761 0
FOXA1 MCF7GSE15244 83461868 83462196 328 0
FOXA1 MCF7GSE15244 83490064 83492449 2385 0
FoxA1 MCF7MACSdata 83392460 83392767 307 0
FoxA1 MCF7MACSdata 83392846 83393206 360 0
FoxA1 MCF7MACSdata 83407143 83407319 176 0
FoxA1 MCF7MACSdata 83437244 83437475 231 0
FoxA1 MCF7MACSdata 83461554 83462006 452 0
FoxA1 MCF7MACSdata 83491020 83491389 369 0
FoxA1 MCF7MACSdata 83491662 83491828 166 0
Nanog ESGSE20650 83400766 83401505 739 0
Nanog hESGSE18292 83470228 83470913 685 0
Oct1 H2O2-HelaGSE14283 83426812 83426846 34 0
Oct1 H2O2-HelaGSE14283 83429528 83429558 30 0
Oct1 H2O2-HelaGSE14283 83445346 83445389 43 0
Oct1 HelaGSE14283 83426814 83426845 31 0
Oct4 hESGSE21916 83400765 83401316 551 0
RARA MCF7GSE15244 83391918 83393798 1880 0
RARA MCF7GSE15244 83489677 83491814 2137 0
RNAII Tamoxifen-MCF7GSE14664 83461067 83461108 41 0
Rb QuiescentGSE19898 83456365 83456492 127 0
Rb shRbSenescenceGSE19898 83461587 83461742 155 0
TFAP2C MCF7GSE21234 83406946 83407395 449 0
TFAP2C MCF7GSE21234 83409538 83410327 789 0
TFAP2C MCF7GSE21234 83490903 83491412 509 0
USF2 HepG2E 83486307 83486657 350 0
hScc1 BcellGSE12603 83492574 83493393 819 0
hScc1 CdLSGSE12603 83491589 83492240 651 0
hScc1 G2GSE9613 83491169 83493172 2003 0
p130 shRbSenescentGSE19898 83480115 83480276 161 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-125a-3p hsa-mir-125a 19 20937217
hsa-miR-125a-5p hsa-mir-125a 19 20937217
hsa-miR-150 hsa-mir-150 19 20937217
hsa-miR-150* hsa-mir-150 19 20937217
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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