Annotation Detail for TLR4

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Basic Information Top

Gene Symbol:	TLR4 ( ARMD10,CD284,TOLL,hToll )
Gene Full Name:	toll-like receptor 4
Band:	9q33.1
Quick Links	Entrez ID:7099; OMIM: 603030; Uniprot ID:TLR4_HUMAN; ENSEMBL ID: ENSG00000136869; HGNC ID: 11850
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:10 results
Experimental PTM Sites from dbPTM:10 results
Predicted PTM Sites by profile HMM from dbPTM:23 results

Location(AA)	Modification
35	N-linked (GlcNAc...).
173	N-linked (GlcNAc...).
205	N-linked (GlcNAc...).
282	N-linked (GlcNAc...).
309	N-linked (GlcNAc...).
497	N-linked (GlcNAc...).
526	N-linked (GlcNAc...).
575	N-linked (GlcNAc...).
624	N-linked (GlcNAc...).
630	N-linked (GlcNAc...) (Potential).

Location(AA)	Modifications	Resource
35	N-linked (GlcNAc...).	Swiss-Prot 53.0
173	N-linked (GlcNAc...).	Swiss-Prot 53.0
205	N-linked (GlcNAc...).	Swiss-Prot 53.0
282	N-linked (GlcNAc...).	Swiss-Prot 53.0
309	N-linked (GlcNAc...).	Swiss-Prot 53.0
497	N-linked (GlcNAc...).	Swiss-Prot 53.0
526	N-linked (GlcNAc...).	Swiss-Prot 53.0
575	N-linked (GlcNAc...).	Swiss-Prot 53.0
624	N-linked (GlcNAc...).	Swiss-Prot 53.0
630	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0

Location(AA)	Modification	Resource
35	N-linked	HMM predict
38	Phosphotyrosine(SRC)	HMM predict
98	Phosphotyrosine(INSR)	HMM predict
98	Phosphotyrosine(EGFR)	HMM predict
151	Phosphothreonine(PKC)	HMM predict
173	N-linked	HMM predict
176	N-linked	HMM predict
282	N-linked	HMM predict
309	N-linked	HMM predict
314	Phosphoserine(CK1)	HMM predict
314	O-linked	HMM predict
390	S-palmitoyl	HMM predict
391	S-palmitoyl	HMM predict
392	Phosphoserine(ATM)	HMM predict
497	N-linked	HMM predict
575	N-linked	HMM predict
579	N-linked	HMM predict
624	N-linked	HMM predict
630	N-linked	HMM predict
674	Phosphotyrosine(EGFR)	HMM predict
674	Phosphotyrosine(SRC)	HMM predict
682	Phosphoserine(ATM)	HMM predict
682	Phosphoserine(CK2)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_138554
Location:chr9 119506430-119519584
strand:+

Upstream the gene:2 results
Downstream the gene:1 results
Inside the gene:2 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Nanog	hES	GSE18292	119490770	119491057	287	15517
Oct1	Hela	GSE14283	119488253	119488283	30	18163

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Oct1	Hela	GSE14283	119532744	119532772	28	13174

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Oct1	H2O2-Hela	GSE14283	119514939	119514969	30	0
Oct1	Hela	GSE14283	119514938	119514972	34	0

Validated miRNA targets

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miR Walk:179 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	17660297
hsa-let-7a*	hsa-let-7a-1	9	17660297
hsa-let-7e	hsa-let-7e	19	19699171
hsa-let-7e*	hsa-let-7e	19	19699171
hsa-let-7f	hsa-let-7f-1	9	21266501
hsa-let-7f	hsa-let-7f-2	X	21266501
hsa-let-7g	hsa-let-7g	3	21266501
hsa-let-7g*	hsa-let-7g	3	21266501
hsa-let-7i	hsa-let-7i	12	19903813
hsa-let-7i	hsa-let-7i	12	17660297
hsa-let-7i*	hsa-let-7i	12	19903813
hsa-let-7i*	hsa-let-7i	12	17660297
hsa-miR-105	hsa-mir-105-1	X	19509287
hsa-miR-105	hsa-mir-105-2	X	19509287
hsa-miR-10a	hsa-mir-10a	17	21266501
hsa-miR-10a*	hsa-mir-10a	17	21266501
hsa-miR-125a-3p	hsa-mir-125a	19	21060679
hsa-miR-125a-5p	hsa-mir-125a	19	21060679
hsa-miR-125b	hsa-mir-125b-1	11	21062749
hsa-miR-125b	hsa-mir-125b-2	21	21062749
hsa-miR-125b	hsa-mir-125b-1	11	21060679
hsa-miR-125b	hsa-mir-125b-2	21	21060679
hsa-miR-125b	hsa-mir-125b-1	11	20435889
hsa-miR-125b	hsa-mir-125b-2	21	20435889
hsa-miR-125b	hsa-mir-125b-1	11	19699171
hsa-miR-125b	hsa-mir-125b-2	21	19699171
hsa-miR-125b-1*	hsa-mir-125b-1	11	21060679
hsa-miR-125b-2*	hsa-mir-125b-2	21	21060679
hsa-miR-126	hsa-mir-126	9	20083669
hsa-miR-126	hsa-mir-126	9	19843690
hsa-miR-126*	hsa-mir-126	9	20083669
hsa-miR-126*	hsa-mir-126	9	19843690
hsa-miR-132	hsa-mir-132	17	16885212
hsa-miR-132*	hsa-mir-132	17	16885212
hsa-miR-142-3p	hsa-mir-142	17	21037424
hsa-miR-142-5p	hsa-mir-142	17	21037424
hsa-miR-144	hsa-mir-144	17	21266501
hsa-miR-144*	hsa-mir-144	17	21266501
hsa-miR-146a	hsa-mir-146a	5	21178010
hsa-miR-146a	hsa-mir-146a	5	21062749
hsa-miR-146a	hsa-mir-146a	5	21060679
hsa-miR-146a	hsa-mir-146a	5	20951969
hsa-miR-146a	hsa-mir-146a	5	20937840
hsa-miR-146a	hsa-mir-146a	5	20933052
hsa-miR-146a	hsa-mir-146a	5	20721625
hsa-miR-146a	hsa-mir-146a	5	20616571
hsa-miR-146a	hsa-mir-146a	5	20524934
hsa-miR-146a	hsa-mir-146a	5	20435894
hsa-miR-146a	hsa-mir-146a	5	19840932
hsa-miR-146a	hsa-mir-146a	5	18791161
hsa-miR-146a	hsa-mir-146a	5	18701320
hsa-miR-146a	hsa-mir-146a	5	18504431
hsa-miR-146a	hsa-mir-146a	5	18383392
hsa-miR-146a	hsa-mir-146a	5	18291670
hsa-miR-146a	hsa-mir-146a	5	16885212
hsa-miR-146a*	hsa-mir-146a	5	21178010
hsa-miR-146a*	hsa-mir-146a	5	21062749
hsa-miR-146a*	hsa-mir-146a	5	21060679
hsa-miR-146a*	hsa-mir-146a	5	20951969
hsa-miR-146a*	hsa-mir-146a	5	20937840
hsa-miR-146a*	hsa-mir-146a	5	20933052
hsa-miR-146a*	hsa-mir-146a	5	20721625
hsa-miR-146a*	hsa-mir-146a	5	20616571
hsa-miR-146a*	hsa-mir-146a	5	20524934
hsa-miR-146a*	hsa-mir-146a	5	20435894
hsa-miR-146a*	hsa-mir-146a	5	19840932
hsa-miR-146a*	hsa-mir-146a	5	18791161
hsa-miR-146a*	hsa-mir-146a	5	18701320
hsa-miR-146a*	hsa-mir-146a	5	18504431
hsa-miR-146a*	hsa-mir-146a	5	18383392
hsa-miR-146a*	hsa-mir-146a	5	18291670
hsa-miR-146a*	hsa-mir-146a	5	16885212
hsa-miR-146b-3p	hsa-mir-146b	10	21060679
hsa-miR-146b-3p	hsa-mir-146b	10	20616571
hsa-miR-146b-3p	hsa-mir-146b	10	20524934
hsa-miR-146b-3p	hsa-mir-146b	10	18701320
hsa-miR-146b-3p	hsa-mir-146b	10	18504431
hsa-miR-146b-3p	hsa-mir-146b	10	18291670
hsa-miR-146b-3p	hsa-mir-146b	10	16885212
hsa-miR-146b-5p	hsa-mir-146b	10	21060679
hsa-miR-146b-5p	hsa-mir-146b	10	20616571
hsa-miR-146b-5p	hsa-mir-146b	10	20524934
hsa-miR-146b-5p	hsa-mir-146b	10	18701320
hsa-miR-146b-5p	hsa-mir-146b	10	18504431
hsa-miR-146b-5p	hsa-mir-146b	10	18291670
hsa-miR-146b-5p	hsa-mir-146b	10	16885212
hsa-miR-147	hsa-mir-147	9	19721002
hsa-miR-148a	hsa-mir-148a	7	21068402
hsa-miR-148a*	hsa-mir-148a	7	21068402
hsa-miR-148b	hsa-mir-148b	12	21068402
hsa-miR-148b*	hsa-mir-148b	12	21068402
hsa-miR-152	hsa-mir-152	17	21068402
hsa-miR-153	hsa-mir-153-1	2	21266501
hsa-miR-153	hsa-mir-153-2	7	21266501
hsa-miR-155	hsa-mir-155	21	21062749
hsa-miR-155	hsa-mir-155	21	21060679
hsa-miR-155	hsa-mir-155	21	21030878
hsa-miR-155	hsa-mir-155	21	20852130
hsa-miR-155	hsa-mir-155	21	20435894
hsa-miR-155	hsa-mir-155	21	19699171
hsa-miR-155	hsa-mir-155	21	19193853
hsa-miR-155	hsa-mir-155	21	18701320
hsa-miR-155	hsa-mir-155	21	18481999
hsa-miR-155	hsa-mir-155	21	18383392
hsa-miR-155	hsa-mir-155	21	18291670
hsa-miR-155	hsa-mir-155	21	17242365
hsa-miR-155	hsa-mir-155	21	16885212
hsa-miR-155*	hsa-mir-155	21	21062749
hsa-miR-155*	hsa-mir-155	21	21060679
hsa-miR-155*	hsa-mir-155	21	21030878
hsa-miR-155*	hsa-mir-155	21	20852130
hsa-miR-155*	hsa-mir-155	21	20435894
hsa-miR-155*	hsa-mir-155	21	19699171
hsa-miR-155*	hsa-mir-155	21	19193853
hsa-miR-155*	hsa-mir-155	21	18701320
hsa-miR-155*	hsa-mir-155	21	18481999
hsa-miR-155*	hsa-mir-155	21	18383392
hsa-miR-155*	hsa-mir-155	21	18291670
hsa-miR-155*	hsa-mir-155	21	17242365
hsa-miR-155*	hsa-mir-155	21	16885212
hsa-miR-16	hsa-mir-16-1	13	21266501
hsa-miR-16	hsa-mir-16-2	3	21266501
hsa-miR-181a	hsa-mir-181a-2	9	18701320
hsa-miR-181a	hsa-mir-181a-1	1	18701320
hsa-miR-181a	hsa-mir-181a-2	9	18291670
hsa-miR-181a	hsa-mir-181a-1	1	18291670
hsa-miR-181c	hsa-mir-181c	19	19699171
hsa-miR-181c*	hsa-mir-181c	19	19699171
hsa-miR-195	hsa-mir-195	17	21266501
hsa-miR-195*	hsa-mir-195	17	21266501
hsa-miR-196a	hsa-mir-196a-1	17	18291670
hsa-miR-196a	hsa-mir-196a-2	12	18291670
hsa-miR-196a*	hsa-mir-196a-2	12	18291670
hsa-miR-196b	hsa-mir-196b	7	21266501
hsa-miR-196b	hsa-mir-196b	7	18291670
hsa-miR-203	hsa-mir-203	14	18291670
hsa-miR-21	hsa-mir-21	17	21266501
hsa-miR-21	hsa-mir-21	17	20435894
hsa-miR-21	hsa-mir-21	17	19946272
hsa-miR-21*	hsa-mir-21	17	21266501
hsa-miR-21*	hsa-mir-21	17	20435894
hsa-miR-21*	hsa-mir-21	17	19946272
hsa-miR-211	hsa-mir-211	15	21266501
hsa-miR-22	hsa-mir-22	17	21037424
hsa-miR-22*	hsa-mir-22	17	21037424
hsa-miR-221	hsa-mir-221	X	20435889
hsa-miR-221*	hsa-mir-221	X	20435889
hsa-miR-223	hsa-mir-223	X	18791161
hsa-miR-223	hsa-mir-223	X	18701320
hsa-miR-223	hsa-mir-223	X	18291670
hsa-miR-223*	hsa-mir-223	X	18791161
hsa-miR-223*	hsa-mir-223	X	18701320
hsa-miR-223*	hsa-mir-223	X	18291670
hsa-miR-25	hsa-mir-25	7	21266501
hsa-miR-25*	hsa-mir-25	7	21266501
hsa-miR-28-3p	hsa-mir-28	3	20636339
hsa-miR-28-5p	hsa-mir-28	3	20636339
hsa-miR-29a	hsa-mir-29a	7	20564213
hsa-miR-29a*	hsa-mir-29a	7	20564213
hsa-miR-29b	hsa-mir-29b-1	7	20564213
hsa-miR-29b	hsa-mir-29b-2	1	20564213
hsa-miR-29b-1*	hsa-mir-29b-1	7	20564213
hsa-miR-29b-2*	hsa-mir-29b-2	1	20564213
hsa-miR-29c	hsa-mir-29c	1	20564213
hsa-miR-29c*	hsa-mir-29c	1	20564213
hsa-miR-34a	hsa-mir-34a	1	21266501
hsa-miR-34a*	hsa-mir-34a	1	21266501
hsa-miR-361-3p	hsa-mir-361	X	21266501
hsa-miR-361-5p	hsa-mir-361	X	21266501
hsa-miR-367	hsa-mir-367	4	21266501
hsa-miR-367*	hsa-mir-367	4	21266501
hsa-miR-449b	hsa-mir-449b	5	21266501
hsa-miR-455-3p	hsa-mir-455	9	21060679
hsa-miR-455-5p	hsa-mir-455	9	21060679
hsa-miR-579	hsa-mir-579	5	20435889
hsa-miR-9	hsa-mir-9-1	1	19289835
hsa-miR-9	hsa-mir-9-2	5	19289835
hsa-miR-9	hsa-mir-9-3	15	19289835
hsa-miR-9*	hsa-mir-9-1	1	19289835

Cis-Nats regulation

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Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for TLR4

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics