AutismKB 2.0

Annotation Detail for TOP1


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Basic Information Top
Gene Symbol:TOP1 ( TOPI )
Gene Full Name: topoisomerase (DNA) I
Band: 20q12
Quick LinksEntrez ID:7150; OMIM: 126420; Uniprot ID:TOP1_HUMAN; ENSEMBL ID: ENSG00000198900; HGNC ID: 11986
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylserine.
112Phosphoserine.
280N6-acetyllysine.
Location(AA) Modifications Resource
10PhosphoserinePhospho.ELM 6.0
268Phosphotyrosine (Abl)Phospho.ELM 6.0
Location(AA) Modification Resource
8N-linkedHMM predict
47Phosphoserine(CK1)HMM predict
50Phosphoserine(CK2)HMM predict
73Phosphoserine(CK1)HMM predict
97Phosphoserine(CK2)HMM predict
112Phosphoserine(CDC2)HMM predict
125Phosphotyrosine(Syk)HMM predict
125Phosphotyrosine(INSR)HMM predict
125SulfotyrosineHMM predict
147Phosphotyrosine(Syk)HMM predict
157Phosphothreonine(CK2)HMM predict
211Phosphotyrosine(EGFR)HMM predict
296N-linkedHMM predict
313Phosphothreonine(PKC)HMM predict
364MethylarginineHMM predict
446Phosphothreonine(PKC)HMM predict
686Phosphoserine(PKC)HMM predict
745N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003286
  • Location:chr20 39090875-39186537
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 39089766 39090451 685 767
LIN9 G0GSE7516 39089766 39090970 1204 508
LIN9 SGSE7516 39089871 39090898 1027 491
Myc K562GSE19551 39089922 39091103 1181 363
PHF8 293TGSE20725 39090104 39091446 1342 101
TFAP2C MCF7GSE21234 39079415 39080228 813 11054
USF1 HepG2E 39089766 39090825 1059 580
USF2 HepG2E 39089766 39090206 440 890
hScc1 BcellGSE12603 39075160 39075303 143 15644
p130 QuiescentGSE19898 39090346 39090661 315 372
p130 SenescentGSE19898 39090018 39091093 1075 320
p130 shRbQuiescentGSE19898 39090101 39090965 864 343
p130 shRbSenescentGSE19898 39090216 39090813 597 361
p130 SGSE7516 39090206 39090934 728 306
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 39157373 39157757 384 0
CTCF CD4SISSRdata 39157373 39157757 384 0
CTCF G2GSE9613 39180188 39180428 240 0
FOXA1 MCF7GSE15244 39148735 39149594 859 0
FOXA1 eGFPGSE10845 39148735 39149594 859 0
Gata2 K562GSE18868 39096226 39096806 580 0
H3ac HepG2E 39091962 39095184 3222 0
H3ac HepG2E 39101075 39101350 275 0
Myc K562GSE19551 39096345 39096713 368 0
Myc K562GSE19551 39126600 39126845 245 0
NFkBII GM12892GSE19485 39089981 39092320 2339 0
Nanog ESGSE20650 39097319 39097766 447 0
Nanog hESGSE18292 39097326 39097818 492 0
RARA MCF7GSE15244 39148663 39149665 1002 0
Stat6 IL-4-hr4GSE17850 39126502 39126999 497 0
TAF HelaGSE8489 39092042 39092805 763 0
TFAP2C MCF7GSE21234 39148854 39149578 724 0
hScc1 BcellGSE12603 39090336 39091895 1559 0
hScc1 BcellGSE12603 39126452 39126883 431 0
hScc1 CdLSGSE12603 39126452 39126883 431 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-24 hsa-mir-24-1 9 21159603
hsa-miR-24 hsa-mir-24-2 19 21159603
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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