AutismKB 2.0

Annotation Detail for TOP2B


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Basic Information Top
Gene Symbol:TOP2B ( TOPIIB,top2beta )
Gene Full Name: topoisomerase (DNA) II beta 180kDa
Band: 3p24.2
Quick LinksEntrez ID:7155; OMIM: 126431; Uniprot ID:TOP2B_HUMAN; ENSEMBL ID: ENSG00000077097; HGNC ID: 11990
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
365N6-acetyllysine.
367N6-acetyllysine.
373N6-acetyllysine.
431Phosphoserine (By similarity).
639Phosphothreonine.
640Phosphoserine.
992N6-acetyllysine.
1044Nuclear export signal.
1236Phosphoserine.
1292Phosphothreonine.
1336Phosphoserine.
1340Phosphoserine.
1342Phosphoserine.
1344Phosphoserine.
1375Phosphoserine.
1400Phosphoserine.
1403Phosphothreonine.
1413Phosphoserine.
1421Phosphotyrosine.
1424Phosphoserine.
1454Phosphoserine.
1461Phosphoserine.
1466Phosphoserine.
1471Phosphoserine.
1473Phosphoserine.
1476Phosphoserine.
1522Phosphoserine.
1524Phosphoserine.
1526Phosphoserine.
1550Phosphoserine.
1552Phosphoserine.
1575Phosphothreonine.
1576Phosphoserine.
1581Phosphoserine.
1592Phosphothreonine.
1596Phosphoserine.
1609Phosphotyrosine.
1613Phosphoserine.
Location(AA) Modifications Resource
639Phosphothreonine.Swiss-Prot 53.0
639PhosphothreoninePhospho.ELM 6.0
640Phosphoserine.Swiss-Prot 53.0
640PhosphoserinePhospho.ELM 6.0
1336Phosphoserine.Swiss-Prot 53.0
1336PhosphoserinePhospho.ELM 6.0
1340Phosphoserine.Swiss-Prot 53.0
1340PhosphoserinePhospho.ELM 6.0
1342Phosphoserine.Swiss-Prot 53.0
1342PhosphoserinePhospho.ELM 6.0
1344Phosphoserine.Swiss-Prot 53.0
1344PhosphoserinePhospho.ELM 6.0
1400Phosphoserine.Swiss-Prot 53.0
1400PhosphoserinePhospho.ELM 6.0
1413PhosphoserinePhospho.ELM 6.0
1413Phosphoserine.Swiss-Prot 53.0
1466Phosphoserine.Swiss-Prot 53.0
1471PhosphoserinePhospho.ELM 6.0
1471Phosphoserine.Swiss-Prot 53.0
1522Phosphoserine.Swiss-Prot 53.0
1522PhosphoserinePhospho.ELM 6.0
1524PhosphoserinePhospho.ELM 6.0
1524Phosphoserine.Swiss-Prot 53.0
1526Phosphoserine (By similarity).Swiss-Prot 53.0
1526PhosphoserinePhospho.ELM 6.0
1550Phosphoserine.Swiss-Prot 53.0
1550PhosphoserinePhospho.ELM 6.0
1552Phosphoserine (By similarity).Swiss-Prot 53.0
1552PhosphoserinePhospho.ELM 6.0
1576PhosphoserinePhospho.ELM 6.0
1581PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
37Phosphoserine(CK2)HMM predict
37Phosphoserine(CK1)HMM predict
43N-linkedHMM predict
55Phosphotyrosine(EGFR)HMM predict
122N-linkedHMM predict
172Phosphotyrosine(Syk)HMM predict
172Phosphotyrosine(INSR)HMM predict
235Phosphotyrosine(INSR)HMM predict
261Phosphothreonine(PKC)HMM predict
291Phosphotyrosine(EGFR)HMM predict
391N-linkedHMM predict
401N-linkedHMM predict
543Phosphotyrosine(Syk)HMM predict
548Phosphoserine(CK1)HMM predict
602Phosphoserine(PKG)HMM predict
735Phosphoserine(CK1)HMM predict
771Phosphoserine(CK2)HMM predict
862Phosphotyrosine(INSR)HMM predict
928Phosphotyrosine(Syk)HMM predict
966N-linkedHMM predict
994Phosphothreonine(PKC)HMM predict
1105Phosphoserine(ATM)HMM predict
1124PhosphothreonineHMM predict
1131Phosphoserine(CK1)HMM predict
1132Phosphoserine(CK1)HMM predict
1133Phosphoserine(CK1)HMM predict
1135Phosphoserine(IKK)HMM predict
1137Phosphothreonine(CDC2)HMM predict
1139Phosphoserine(ATM)HMM predict
1180Phosphoserine(CDK)HMM predict
1236Phosphoserine(CDC2)HMM predict
1317Phosphothreonine(MAPK)HMM predict
1320Phosphoserine(CDC2)HMM predict
1321O-linkedHMM predict
1340Phosphoserine(IKK)HMM predict
1340Phosphoserine(CK1)HMM predict
1342Phosphoserine(CK1)HMM predict
1344Phosphoserine(CK2)HMM predict
1400Phosphoserine(CDC2)HMM predict
1424Phosphoserine(CDK)HMM predict
1424Phosphoserine(ATM)HMM predict
1424Phosphoserine(CDC2)HMM predict
1431Phosphothreonine(MAPK)HMM predict
1454Phosphoserine(ATM)HMM predict
1466PhosphoserineHMM predict
1466Phosphoserine(CK2)HMM predict
1491Phosphothreonine(PKC)HMM predict
1522Phosphoserine(CK2)HMM predict
1536Phosphothreonine(CDC2)HMM predict
1550Phosphoserine(IKK)HMM predict
1550PhosphoserineHMM predict
1550Phosphoserine(PKG)HMM predict
1558SulfotyrosineHMM predict
1565Phosphoserine(CAMK2)HMM predict
1565Phosphoserine(PKG)HMM predict
1565Phosphoserine(IKK)HMM predict
1568Phosphothreonine(PKC)HMM predict
1592O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001068
  • Location:chr3 25614478-25680791
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 25680435 25681496 1061 174
FOXA1 MCF7GSE15244 25681496 25682145 649 1029
Fos K562GSE19551 25681106 25681809 703 666
FoxA1 MCF7MACSdata 25693725 25693974 249 13058
PHF8 293TGSE20725 25680413 25681879 1466 355
PHF8 HeLaGSE20725 25680322 25681762 1440 251
PHF8 Hs68plusFBSGSE20725 25680155 25681789 1634 181
RARA MCF7GSE15244 25693501 25693967 466 12943
RARA MCF7GSE15244 25694297 25694530 233 13622
TFAP2C MCF7GSE21234 25681457 25681993 536 934
hScc1 CdLSGSE12603 25680518 25681383 865 159
hScc1 G2GSE9613 25680226 25681496 1270 70
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 25664572 25664926 354 0
CTCF CD4SISSRdata 25664572 25664926 354 0
CTCF G2GSE9613 25664248 25664854 606 0
FOXA1 MCF7GSE15244 25664494 25664854 360 0
Fos K562GSE19551 25620538 25621160 622 0
H3K4me2 HCT116GSE10453 25679490 25680190 700 0
H3K4me3 colorectalcancer 25679046 25680435 1389 0
H3ac HepG2E 25679273 25680592 1319 0
Myc K562GSE19551 25664460 25665013 553 0
Oct1 H2O2-HelaGSE14283 25622797 25622825 28 0
RARA MCF7GSE15244 25664494 25664854 360 0
RARA MCF7GSE15244 25679564 25680361 797 0
RARG MCF7GSE15244 25679599 25680226 627 0
TAF k562GSE8489 25678861 25680724 1863 0
TFAP2C MCF7GSE21234 25620211 25620621 410 0
hScc1 BcellGSE12603 25664494 25664854 360 0
hScc1 BcellGSE12603 25680078 25681036 958 0
hScc1 CdLSGSE12603 25664494 25664854 360 0
hScc1 CdLSGSE12603 25678084 25678568 484 0
hScc1 G2GSE9613 25664494 25664854 360 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-21 hsa-mir-21 17 20219416
hsa-miR-21* hsa-mir-21 17 20219416
hsa-miR-214 hsa-mir-214 1 20219416
hsa-miR-214* hsa-mir-214 1 20219416
hsa-miR-23a hsa-mir-23a 19 20219416
hsa-miR-23a* hsa-mir-23a 19 20219416
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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