AutismKB 2.0

Annotation Detail for TPH1


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Basic Information Top
Gene Symbol:TPH1 ( MGC119994,TPRH,TRPH )
Gene Full Name: tryptophan hydroxylase 1
Band: 11p15.1
Quick LinksEntrez ID:7166; OMIM: 191060; Uniprot ID:TPH1_HUMAN; ENSEMBL ID: ENSG00000129167; HGNC ID: 12008
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
58Phosphoserine; by PKA (Potential).
Location(AA) Modifications Resource
58Phosphoserine (by PKA) (Potential).Swiss-Prot 53.0
58Phosphoserine (PKA
Location(AA) Modification Resource
12Phosphoserine(CK1)HMM predict
19Phosphoserine(CAMK2)HMM predict
58Phosphoserine(PKA)HMM predict
58Phosphoserine(PKG)HMM predict
94N-linkedHMM predict
141Phosphotyrosine(Jak)HMM predict
167Phosphothreonine(CK2)HMM predict
264SulfotyrosineHMM predict
265Phosphothreonine(CDC2)HMM predict
265O-linkedHMM predict
290Phosphoserine(ATM)HMM predict
346Phosphoserine(CK2)HMM predict
416Phosphoserine(IKK)HMM predict
439Phosphoserine(PKG)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004179
  • Location:chr11 17999115-18018884
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K27me3 colorectalcancer 18022562 18023957 1395 4375
No data
No data
Validated miRNA targets Top
Cis-Nats regulation Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018