Annotation Detail for TPM1

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Basic Information Top

Gene Symbol:	TPM1 ( C15orf13,CMD1Y,HTM-alpha,TMSA )
Gene Full Name:	tropomyosin 1 (alpha)
Band:	15q22.2
Quick Links	Entrez ID:7168; OMIM: 191010; Uniprot ID:TPM1_HUMAN; ENSEMBL ID: ENSG00000140416; HGNC ID: 12010
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
1	N-acetylmethionine.

Location(AA)	Modifications	Resource
1	N-acetylmethionine.	Swiss-Prot 53.0
61	Phosphoserine (PIK3CA)	Phospho.ELM 6.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	61121194	61122257	1063	165
FoxA1	MCF7	MACSdata	61106270	61106542	272	15485
P300	T30-glioblastoma	GSE21026	61102121	61103419	1298	19121
hScc1	Bcell	GSE12603	61121158	61122340	1182	142
p63	keratinocytes	GSE17611	61117002	61118491	1489	4144

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	CD4	GSE12889	61127248	61127489	241
CTCF	CD4	SISSRdata	61127248	61127489	241
Oct1	H2O2-Hela	GSE14283	61122844	61122874	30
Oct1	H2O2-Hela	GSE14283	61126182	61126219	37
hScc1	Bcell	GSE12603	61122828	61123217	389
hScc1	Bcell	GSE12603	61127227	61127988	761

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-142-3p	hsa-mir-142	17	21394831
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-21	hsa-mir-21	17	20417062
hsa-miR-21	hsa-mir-21	17	19509158
hsa-miR-21	hsa-mir-21	17	19302977
hsa-miR-21	hsa-mir-21	17	18270520
hsa-miR-21	hsa-mir-21	17	17363372
hsa-miR-21*	hsa-mir-21	17	20417062
hsa-miR-21*	hsa-mir-21	17	19509158
hsa-miR-21*	hsa-mir-21	17	19302977
hsa-miR-21*	hsa-mir-21	17	18270520
hsa-miR-21*	hsa-mir-21	17	17363372
hsa-miR-221	hsa-mir-221	X	20417062
hsa-miR-221*	hsa-mir-221	X	20417062
hsa-miR-222	hsa-mir-222	X	20417062
hsa-miR-222*	hsa-mir-222	X	20417062
hsa-miR-29a	hsa-mir-29a	7	21394831
hsa-miR-29a*	hsa-mir-29a	7	21394831
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
533	mRNA repression	TRUE	miR-21	TPM1	Luciferase assay - Seed deletion	17363372
534	mRNA repression	TRUE	miR-21	TPM1	Luciferase assay - Seed deletion	17363372
1206	Unknown	pSILAC	miR-1	TPM1	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000140416		n_a	breast cancer	up regulated	"muscle cell, squamous cell, lymphocyte, epithelium"	"benign tumour, malignant tumour, carcinoma, sarcoma, leukaemia"
ENSG00000140416		"cell invasion and tumor metastasis, G1-to-S transition"	breast cancer	up regulated	"muscle cell, squamous cell, lymphocyte, epithelium"	"benign tumour, malignant tumour, carcinoma, sarcoma, leukaemia"
ENSG00000140416		n_a	n_a	n_a	"muscle cell, squamous cell, lymphocyte, epithelium"	"benign tumour, malignant tumour, carcinoma, sarcoma, leukaemia"

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
8918	mRNA	TPM1	chr15	61127651	61151164	308	mRNA		chr15	61125285	61128639	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018