Annotation Detail for TPM3

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Basic Information Top

Gene Symbol:	TPM3 ( FLJ41118,MGC14582,MGC3261,MGC72094,NEM1,OK/SW-cl.5,TM-5,TM3,TM30,TM30nm,TPMsk3,TRK,hscp30 )
Gene Full Name:	tropomyosin 3
Band:	1q21.3
Quick Links	Entrez ID:7170; OMIM: 191030; Uniprot ID:TPM3_HUMAN; ENSEMBL ID: ENSG00000143549; HGNC ID: 12012
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
12	N6-acetyllysine.
162	Phosphotyrosine.
252	Phosphothreonine.
283	Phosphoserine (By similarity).

Location(AA)	Modifications	Resource
252	Phosphothreonine.	Swiss-Prot 53.0
252	Phosphothreonine	Phospho.ELM 6.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	152421814	152422368	554
GABP	k562	GSE8489	152420045	152420712	667
GABP	k562	GSE8489	152421056	152421460	404
H3K4me2	HCT116	GSE10453	152421056	152421306	250
H3K4me3	colorectal	cancer	152417024	152418665	1641
H3K4me3	colorectal	cancer	152420045	152420712	667
H3K4me3	colorectal	cancer	152421056	152421424	368
H3ac	HepG2	E	152419137	152419682	545
H3ac	HepG2	E	152420045	152420712	667
H3ac	HepG2	E	152421056	152422219	1163
Oct1	Hela	GSE14283	152396925	152396972	47
PHF8	HeLa	GSE20725	152421594	152422851	1257
RARA	MCF7	GSE15244	152396319	152397570	1251
RARA	MCF7	GSE15244	152419137	152419645	508
TAF	k562	GSE8489	152421056	152421306	250
TFAP2C	MCF7	GSE21234	152396476	152397183	707
TFAP2C	MCF7	GSE21234	152421283	152422787	1504
hScc1	Bcell	GSE12603	152421306	152422627	1321
p130	shRbQuiescent	GSE19898	152421925	152422754	829

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
1110	Unknown	pSILAC	miR-16	TPM3	down 50-25%	18668040
1111	Unknown	pSILAC	miR-16	TPM3	down 50-25%	18668040
1208	Unknown	pSILAC	miR-1	TPM3	down 75-50%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000143549		n_a	n_a	n_a	"epithelium, squamous cell, lymphoblast, lymphocyte, leukocyte, macrophage, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000143549		n_a	n_a	n_a	"epithelium, squamous cell, lymphoblast, lymphocyte, leukocyte, macrophage, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000143549		n_a	n_a	n_a	"epithelium, squamous cell, lymphoblast, lymphocyte, leukocyte, macrophage, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018