AutismKB 2.0

Annotation Detail for TPM4


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Basic Information Top
Gene Symbol:TPM4 ( - )
Gene Full Name: tropomyosin 4
Band: 19p13.12-p13.11
Quick LinksEntrez ID:7171; OMIM: 600317; Uniprot ID:TPM4_HUMAN; ENSEMBL ID: ENSG00000167460; HGNC ID: 12013
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
76N6-acetyllysine.
125N6-acetyllysine.
126Phosphotyrosine.
177N6-acetyllysine.
184N6-acetyllysine.
215N6-acetyllysine.
Location(AA) Modifications Resource
2N-acetylalanine.Swiss-Prot 53.0
Location(AA) Modification Resource
126Phosphotyrosine(Syk)HMM predict
163N-linkedHMM predict
166N-linkedHMM predict
167N-linkedHMM predict
179Phosphoserine(CK1)HMM predict
179Phosphoserine(CK2)HMM predict
185Phosphotyrosine(EGFR)HMM predict
185Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003290
  • Location:chr19 16048324-16074407
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 16034561 16034804 243 13642
CTCF CD4SISSRdata 16034561 16034804 243 13642
CTCF HelaGSE12889 16034593 16034897 304 13580
CTCF JurkatGSE12889 16034496 16034808 312 13673
CTCF G2GSE9613 16038352 16038654 302 9822
FoxA1 MCF7MACSdata 16032195 16032423 228 16016
H3K4me2 HCT116GSE10453 16040638 16040918 280 7547
TAF HelaGSE8489 16040638 16040918 280 7547
TFAP2C MCF7GSE21234 16042148 16042928 780 5787
hScc1 BcellGSE12603 16038232 16038611 379 9903
hScc1 BcellGSE12603 16039166 16039579 413 8952
hScc1 CdLSGSE12603 16038314 16038915 601 9710
p130 SenescentGSE19898 16040796 16041151 355 7351
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Pol2 GM12878GSE19551 16074823 16075333 510 671
VDR GM10861-UnstimGSE22484 16074351 16077016 2665 1276
VDR GM10861-stimGSE22484 16072960 16076187 3227 166
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 16057019 16058881 1862 0
FOXA1 MCF7GSE15244 16053661 16053861 200 0
FOXA1 MCF7GSE15244 16065319 16065721 402 0
FoxA1 MCF7MACSdata 16053786 16054052 266 0
FoxA1 MCF7MACSdata 16065537 16065729 192 0
FoxA1 MCF7MACSdata 16069697 16069914 217 0
Gata2 K562GSE18868 16058081 16058718 637 0
H3ac HepG2E 16049897 16051471 1574 0
Oct1 HelaGSE14283 16067575 16067626 51 0
PHF8 HeLaGSE20725 16047644 16049081 1437 0
Rb QuiescentGSE19898 16048408 16048641 233 0
SRF GMOGSE8489 16049897 16051471 1574 0
SRF HelaGSE8489 16049897 16051471 1574 0
SRF k562GSE8489 16049897 16051471 1574 0
TAF HelaGSE8489 16049897 16051326 1429 0
TAF k562GSE8489 16049897 16050307 410 0
TFAP2C MCF7GSE21234 16065371 16065801 430 0
TFAP2C MCF7GSE21234 16069687 16070056 369 0
hScc1 BcellGSE12603 16048095 16048790 695 0
p130 QuiescentGSE19898 16048600 16048846 246 0
p130 QuiescentGSE19898 16049172 16049457 285 0
p130 QuiescentGSE19898 16050218 16050598 380 0
p130 SenescentGSE19898 16049857 16050666 809 0
p130 shRbQuiescentGSE19898 16049093 16049715 622 0
p130 shRbQuiescentGSE19898 16049904 16050455 551 0
p130 shRbQuiescentGSE19898 16051614 16052341 727 0
p130 shRbSenescentGSE19898 16050123 16050906 783 0
p130 shRbSenescentGSE19898 16050918 16051168 250 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
207 Unknown MicroArray miR-1 TPM4 n_a 15685193
1209 Unknown pSILAC miR-1 TPM4 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000167460 "cardiac and skeletal muscles, cardiogenesis" n_a n_a "epithelium, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000167460 n_a n_a n_a "epithelium, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
12843 mRNA TPM4 chr19 16048324 16074408 183 mRNA chr19 16046102 16049205Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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