AutismKB 2.0

Annotation Detail for TPMT


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Basic Information Top
Gene Symbol:TPMT ( - )
Gene Full Name: thiopurine S-methyltransferase
Band: 6p22.3
Quick LinksEntrez ID:7172; OMIM: 187680; Uniprot ID:TPMT_HUMAN; ENSEMBL ID: ENSG00000137364; HGNC ID: 12014
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
14Phosphoserine.
58N6-acetyllysine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
13Phosphotyrosine(Syk)HMM predict
106Phosphoserine(CK2)HMM predict
127N-linkedHMM predict
166Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000367
  • Location:chr6 18236525-18263352
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Rb SenescentGSE19898 18263096 18263617 521 4
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 18242632 18242962 330 0
H3ac HepG2E 18261775 18262554 779 0
H3ac HepG2E 18263021 18263266 245 0
TAF HelaGSE8489 18263021 18263229 208 0
TAF k562GSE8489 18263021 18263266 245 0
hScc1 BcellGSE12603 18263059 18263553 494 0
p130 QuiescentGSE19898 18262977 18263598 621 0
p130 shRbQuiescentGSE19898 18262848 18263572 724 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018