AutismKB 2.0

Annotation Detail for HSP90B1


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Basic Information Top
Gene Symbol:HSP90B1 ( ECGP,GP96,GRP94,TRA1 )
Gene Full Name: heat shock protein 90kDa beta (Grp94), member 1
Band: 12q23.3
Quick LinksEntrez ID:7184; OMIM: 191175; Uniprot ID:ENPL_HUMAN; ENSEMBL ID: ENSG00000166598; HGNC ID: 12028
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
62N-linked (GlcNAc...).
107N-linked (GlcNAc...).
217N-linked (GlcNAc...).
306Phosphoserine (By similarity).
445N-linked (GlcNAc...).
481N-linked (GlcNAc...) (Potential).
502N-linked (GlcNAc...) (Potential).
677Phosphotyrosine.
803Prevents secretion from ER.
Location(AA) Modifications Resource
62N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
107N-linked (GlcNAc...).Swiss-Prot 53.0
217N-linked (GlcNAc...).Swiss-Prot 53.0
445N-linked (GlcNAc...).Swiss-Prot 53.0
481N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
502N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
10S-palmitoylHMM predict
11S-palmitoylHMM predict
62N-linkedHMM predict
107N-linkedHMM predict
127Phosphoserine(CK2)HMM predict
155Phosphothreonine(PKC)HMM predict
171Phosphothreonine(PKC)HMM predict
217N-linkedHMM predict
256Phosphoserine(CK2)HMM predict
258Phosphotyrosine(Syk)HMM predict
306Phosphoserine(CK2)HMM predict
306Phosphoserine(CK1)HMM predict
306PhosphoserineHMM predict
355Phosphotyrosine(SRC)HMM predict
355Phosphotyrosine(Syk)HMM predict
355Phosphotyrosine(EGFR)HMM predict
355SulfotyrosineHMM predict
363Phosphoserine(PKC)HMM predict
408Phosphotyrosine(EGFR)HMM predict
408Phosphotyrosine(INSR)HMM predict
480Phosphotyrosine(Syk)HMM predict
481N-linkedHMM predict
502N-linkedHMM predict
563Phosphotyrosine(Syk)HMM predict
563Phosphotyrosine(INSR)HMM predict
601Phosphoserine(CK2)HMM predict
643Phosphoserine(IKK)HMM predict
669Phosphothreonine(PKC)HMM predict
678Phosphotyrosine(Syk)HMM predict
796Phosphoserine(PKG)HMM predict
796Phosphoserine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003299
  • Location:chr12 102848318-102865832
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 102848006 102848411 405 110
ETS1 JurkatGSE17954 102846587 102848536 1949 757
FOXA1 DLD1GSE12801 102846441 102846815 374 1691
FOXA1 MCF7GSE15244 102847285 102848448 1163 452
H3K4me3 colorectalcancer 102846594 102847204 610 1420
H3ac HepG2E 102846479 102847634 1155 1262
LIN9 G0GSE7516 102847756 102848842 1086 20
Oct1 HelaGSE14283 102832083 102832139 56 16208
PHF8 Hs68minusFBSGSE20725 102846877 102848118 1241 821
PHF8 Hs68plusFBSGSE20725 102846799 102848027 1228 906
Rb SenescentGSE19898 102847866 102848504 638 134
USF1 HepG2E 102847431 102848377 946 415
hScc1 BcellGSE12603 102848006 102848559 553 36
hScc1 CdLSGSE12603 102846179 102847598 1419 1430
hScc1 CdLSGSE12603 102847854 102848727 873 28
p130 QuiescentGSE19898 102847071 102848654 1583 456
p130 SenescentGSE19898 102843419 102843752 333 4733
p130 SenescentGSE19898 102847128 102848549 1421 480
p130 shRbQuiescentGSE19898 102847070 102849140 2070 214
p130 shRbSenescentGSE19898 102847070 102848588 1518 490
p130 G0GSE7516 102847827 102848559 732 126
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 102874030 102874763 733 8564
H3K4me3 colorectalcancer 102873813 102874215 402 8182
H3ac HepG2E 102873591 102875499 1908 8713
RARA MCF7GSE15244 102874030 102875499 1469 8932
USF1 HepG2E 102873591 102875603 2012 8765
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 102847827 102848926 1099 0
ER E2-MCF7GSE14664 102852092 102852126 34 0
H3K4me3 colorectalcancer 102849029 102849966 937 0
H3ac HepG2E 102848593 102850263 1670 0
LIN9 SGSE7516 102847756 102848926 1170 0
PHF8 293TGSE20725 102846949 102849789 2840 0
PHF8 HeLaGSE20725 102848138 102849043 905 0
PHF8 Hs68plusFBSGSE20725 102848086 102849587 1501 0
TAF k562GSE8489 102848993 102850343 1350 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-15a hsa-mir-15a 13 18362358
hsa-miR-15a* hsa-mir-15a 13 18362358
hsa-miR-16 hsa-mir-16-1 13 18362358
hsa-miR-16 hsa-mir-16-2 3 18362358
hsa-miR-16-1* hsa-mir-16-1 13 18362358
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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