AutismKB 2.0

Annotation Detail for TRPC6


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TRPC6 ( FLJ11098,FLJ14863,FSGS2,TRP6 )
Gene Full Name: transient receptor potential cation channel, subfamily C, member 6
Band: 11q22.1
Quick LinksEntrez ID:7225; OMIM: 603652; Uniprot ID:TRPC6_HUMAN; ENSEMBL ID: ENSG00000137672; HGNC ID: 12338
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
70Phosphothreonine.
473N-linked (GlcNAc...) (Potential).
561N-linked (GlcNAc...) (Potential).
815Phosphoserine.
839Phosphoserine.
Location(AA) Modifications Resource
70Phosphothreonine.Swiss-Prot 53.0
473N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
561N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
13Phosphoserine(PKC)HMM predict
13PhosphoserineHMM predict
14Phosphoserine(CDC2)HMM predict
14Phosphoserine(PKB)HMM predict
14O-linkedHMM predict
16MethylarginineHMM predict
26N-linkedHMM predict
31Phosphotyrosine(INSR)HMM predict
31Phosphotyrosine(Syk)HMM predict
70Phosphothreonine(PKC)HMM predict
94Phosphoserine(CK1)HMM predict
96Phosphoserine(CK2)HMM predict
123Phosphoserine(CK1)HMM predict
157N-linkedHMM predict
173Phosphotyrosine(Jak)HMM predict
194Phosphothreonine(PKA)HMM predict
195PhosphoserineHMM predict
195Phosphoserine(IKK)HMM predict
195Phosphoserine(CDC2)HMM predict
197Phosphoserine(ATM)HMM predict
199Phosphoserine(CK1)HMM predict
207SulfotyrosineHMM predict
209SulfotyrosineHMM predict
268Phosphoserine(CK1)HMM predict
282Phosphoserine(MAPK)HMM predict
473N-linkedHMM predict
479N-linkedHMM predict
561N-linkedHMM predict
712N-linkedHMM predict
728N-linkedHMM predict
769Phosphoserine(MAPK)HMM predict
769Phosphoserine(CDC2)HMM predict
820Phosphoserine(CK1)HMM predict
906Phosphothreonine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004621
  • Location:chr11 100827582-100959868
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 100971494 100971531 37 11644
FOXA1 MCF7GSE15244 100959696 100960066 370 13
Oct1 H2O2-HelaGSE14283 100973293 100973320 27 13438
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 100808873 100808905 32 18694
ER MCF7GSE19013 100812363 100813056 693 14873
FOXA1 MCF7GSE15244 100817101 100818065 964 10000
Nanog hESGSE18292 100812591 100812816 225 14879
Oct1 H2O2-HelaGSE14283 100819498 100819531 33 8068
RARA MCF7GSE15244 100817414 100818167 753 9792
RARG MCF7GSE15244 100816910 100817992 1082 10132
hScc1 BcellGSE12603 100814096 100814340 244 13365
hScc1 G2GSE9613 100812009 100812912 903 15122
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 DLD1GSE12801 100827656 100828529 873 0
Nanog ESGSE20650 100842295 100842733 438 0
Nanog ESGSE20650 100899794 100900232 438 0
Oct1 H2O2-HelaGSE14283 100955414 100955463 49 0
Oct1 H2O2-HelaGSE14283 100959554 100959591 37 0
Oct1 HelaGSE14283 100852281 100852327 46 0
Oct1 HelaGSE14283 100884544 100884574 30 0
Oct1 HelaGSE14283 100947371 100947413 42 0
Oct1 HelaGSE14283 100955427 100955462 35 0
Oct1 HelaGSE14283 100959554 100959590 36 0
RNAII Tamoxifen-MCF7GSE14664 100897359 100897456 97 0
TFAP2C MCF7GSE21234 100854342 100854811 469 0
TFAP2C MCF7GSE21234 100942982 100943476 494 0
hScc1 BcellGSE12603 100959186 100959525 339 0
p63 keratinocytesGSE17611 100854180 100855151 971 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-125b hsa-mir-125b-1 11 20306291
hsa-miR-125b-1* hsa-mir-125b-1 11 20306291
hsa-miR-646 hsa-mir-646 20 20306291
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved