AutismKB 2.0

Annotation Detail for TTK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TTK ( CT96,ESK,FLJ38280,MPS1,MPS1L1,PYT )
Gene Full Name: TTK protein kinase
Band: 6q14.1
Quick LinksEntrez ID:7272; OMIM: 604092; Uniprot ID:TTK_HUMAN; ENSEMBL ID: ENSG00000112742; HGNC ID: 12401
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
3Phosphoserine.
7Phosphoserine.
33Phosphothreonine.
37Phosphoserine.
49Phosphoserine.
80Phosphoserine.
216Phosphoserine.
218Phosphoserine.
281Phosphoserine.
317Phosphoserine.
321Phosphoserine.
393Phosphoserine.
431Phosphoserine.
436Phosphoserine.
453Phosphothreonine.
455Phosphoserine.
821Phosphoserine.
824Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
90N-linkedHMM predict
115SulfotyrosineHMM predict
198Phosphoserine(IKK)HMM predict
200Phosphoserine(CK1)HMM predict
210N-linkedHMM predict
211N-linkedHMM predict
219Phosphothreonine(PKC)HMM predict
247N-linkedHMM predict
285Phosphothreonine(PKA)HMM predict
285Phosphothreonine(PKC)HMM predict
286Phosphoserine(PKC)HMM predict
329Phosphoserine(CK1)HMM predict
342N-linkedHMM predict
358Phosphotyrosine(INSR)HMM predict
358Phosphotyrosine(SRC)HMM predict
358Phosphotyrosine(EGFR)HMM predict
358Phosphotyrosine(Syk)HMM predict
417Phosphoserine(CDK)HMM predict
433Phosphoserine(IKK)HMM predict
446Phosphotyrosine(INSR)HMM predict
452Phosphothreonine(CDC2)HMM predict
469Phosphotyrosine(Abl)HMM predict
546N-linkedHMM predict
583SulfotyrosineHMM predict
583Phosphotyrosine(Syk)HMM predict
583Phosphotyrosine(INSR)HMM predict
673Phosphotyrosine(INSR)HMM predict
765Phosphoserine(PKG)HMM predict
827N-linkedHMM predict
828Phosphoserine(CDK)HMM predict
829Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003318
  • Location:chr6 80771077-80808955
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 80770669 80771364 695 61
H3K4me3 colorectalcancer 80769990 80770693 703 736
H3ac HepG2E 80769847 80770693 846 808
Oct1 H2O2-HelaGSE14283 80753600 80753629 29 17463
PHF8 Hs68plusFBSGSE20725 80770264 80771766 1502 63
TAF k562GSE8489 80769368 80770436 1068 1176
TFAP2C MCF7GSE21234 80770234 80771121 887 400
p130 shRbQuiescentGSE19898 80770429 80771653 1224 37
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 80770811 80771742 931 0
E2F4 SGSE7516 80770849 80771596 747 0
LIN54 G0GSE7516 80770849 80771669 820 0
LIN9 G0GSE7516 80770388 80772032 1644 0
LIN9 SGSE7516 80770693 80772180 1487 0
TAF k562GSE8489 80771407 80772584 1177 0
p130 QuiescentGSE19898 80770921 80771663 742 0
p130 SenescentGSE19898 80770540 80771711 1171 0
p130 shRbSenescentGSE19898 80770423 80771756 1333 0
p130 G0GSE7516 80770307 80772000 1693 0
p130 SGSE7516 80770620 80771779 1159 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-376a hsa-mir-376a-1 0 17322061
hsa-miR-376a hsa-mir-376a-2 0 17322061
hsa-miR-376a* hsa-mir-376a-1 0 17322061
hsa-miR-376b hsa-mir-376b 0 17322061
hsa-miR-376c hsa-mir-376c 0 17322061
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
695 mRNA repression TRUE miR-376a-5p TTK in vitro reporter gene assay (Luciferase) 17322061
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000112742 n_a n_a n_a "lymphocyte, muscle cell" "malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved