Annotation Detail for TWIST1

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	TWIST1 ( ACS3,BPES2,BPES3,CRS1,SCS,TWIST,bHLHa38 )
Gene Full Name:	twist homolog 1 (Drosophila)
Band:	7p21.1
Quick Links	Entrez ID:7291; OMIM: 601622; Uniprot ID:TWST1_HUMAN; ENSEMBL ID: ENSG00000122691; HGNC ID: 12428
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

Top

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:19 results

No data

Location(AA)	Modification	Resource
7	Phosphoserine(CK1)	HMM predict
8	Phosphoserine(CDK)	HMM predict
8	Phosphoserine	HMM predict
8	Phosphoserine(CDC2)	HMM predict
8	Phosphoserine(IKK)	HMM predict
11	Phosphoserine(IKK)	HMM predict
11	Phosphoserine(ATM)	HMM predict
16	Phosphoserine(IKK)	HMM predict
18	Phosphoserine(CK1)	HMM predict
20	Phosphoserine(IKK)	HMM predict
20	Phosphoserine(CK1)	HMM predict
34	Methylarginine	HMM predict
42	O-linked	HMM predict
94	O-linked	HMM predict
95	O-linked	HMM predict
103	Phosphotyrosine(Syk)	HMM predict
121	Phosphothreonine(PKA)	HMM predict
144	Phosphoserine(CK1)	HMM predict
197	Phosphoserine(IKK)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_000474
Location:chr7 19121617-19123819
strand:-

Upstream the gene:7 results
Downstream the gene:3 results
Inside the gene:5 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3K27me3	colorectal	cancer	19124422	19126517	2095	1650
KLF4	hES	GSE17917	19124658	19124811	153	915
Oct1	Hela	GSE14283	19127738	19127767	29	3933
hScc1	Bcell	GSE12603	19128207	19128449	242	4509
p130	Quiescent	GSE19898	19123648	19124027	379	18
p130	shRbQuiescent	GSE19898	19123637	19124063	426	31
p130	shRbSenescent	GSE19898	19123670	19124044	374	38

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Oct1	Hela	GSE14283	19110305	19110345	40	11293
Rb	Growing	GSE19898	19113595	19113847	252	7897
Rb	Quiescent	GSE19898	19113383	19113944	561	7954

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	19122345	19124605	2260
PHF8	HeLa	GSE20725	19122464	19124231	1767
Rb	Quiescent	GSE19898	19123566	19123842	276
hScc1	Bcell	GSE12603	19123398	19123843	445
hScc1	G2	GSE9613	19122251	19124794	2543

Validated miRNA targets

Top

miR Walk:119 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	21285251
hsa-let-7a	hsa-let-7a-2	11	21285251
hsa-let-7a	hsa-let-7a-3	22	21285251
hsa-let-7a	hsa-let-7a-1	9	21352471
hsa-let-7a	hsa-let-7a-2	11	21352471
hsa-let-7a	hsa-let-7a-3	22	21352471
hsa-let-7a	hsa-let-7a-1	9	17600087
hsa-let-7a	hsa-let-7a-2	11	17600087
hsa-let-7a	hsa-let-7a-3	22	17600087
hsa-let-7a*	hsa-let-7a-1	9	21352471
hsa-let-7a*	hsa-let-7a-3	22	21352471
hsa-let-7a*	hsa-let-7a-1	9	17600087
hsa-let-7a*	hsa-let-7a-3	22	17600087
hsa-let-7b	hsa-let-7b	22	21352471
hsa-let-7b	hsa-let-7b	22	17600087
hsa-let-7b*	hsa-let-7b	22	21352471
hsa-let-7b*	hsa-let-7b	22	17600087
hsa-let-7c	hsa-let-7c	21	21352471
hsa-let-7c	hsa-let-7c	21	17600087
hsa-let-7c*	hsa-let-7c	21	21352471
hsa-let-7c*	hsa-let-7c	21	17600087
hsa-let-7d	hsa-let-7d	9	21352471
hsa-let-7d	hsa-let-7d	9	17600087
hsa-let-7d*	hsa-let-7d	9	21352471
hsa-let-7d*	hsa-let-7d	9	17600087
hsa-let-7e	hsa-let-7e	19	21352471
hsa-let-7e	hsa-let-7e	19	17600087
hsa-let-7e*	hsa-let-7e	19	21352471
hsa-let-7e*	hsa-let-7e	19	17600087
hsa-let-7f	hsa-let-7f-1	9	21352471
hsa-let-7f	hsa-let-7f-2	X	21352471
hsa-let-7f	hsa-let-7f-1	9	17600087
hsa-let-7f	hsa-let-7f-2	X	17600087
hsa-let-7f-1*	hsa-let-7f-1	9	21352471
hsa-let-7f-1*	hsa-let-7f-1	9	17600087
hsa-let-7f-2*	hsa-let-7f-2	X	21352471
hsa-let-7f-2*	hsa-let-7f-2	X	17600087
hsa-let-7g	hsa-let-7g	3	21352471
hsa-let-7g	hsa-let-7g	3	17600087
hsa-let-7g*	hsa-let-7g	3	21352471
hsa-let-7g*	hsa-let-7g	3	17600087
hsa-let-7i	hsa-let-7i	12	21352471
hsa-let-7i	hsa-let-7i	12	17600087
hsa-let-7i*	hsa-let-7i	12	21352471
hsa-let-7i*	hsa-let-7i	12	17600087
hsa-miR-1	hsa-mir-1-2	18	16249329
hsa-miR-1	hsa-mir-1-1	20	16249329
hsa-miR-1	hsa-mir-1-2	18	16166373
hsa-miR-1	hsa-mir-1-1	20	16166373
hsa-miR-10b	hsa-mir-10b	2	20843787
hsa-miR-10b	hsa-mir-10b	2	20732742
hsa-miR-10b	hsa-mir-10b	2	17898713
hsa-miR-10b*	hsa-mir-10b	2	20843787
hsa-miR-10b*	hsa-mir-10b	2	20732742
hsa-miR-10b*	hsa-mir-10b	2	17898713
hsa-miR-125a-3p	hsa-mir-125a	19	20467044
hsa-miR-125b	hsa-mir-125b-1	11	21362569
hsa-miR-125b	hsa-mir-125b-2	21	21362569
hsa-miR-135b	hsa-mir-135b	1	20406893
hsa-miR-135b*	hsa-mir-135b	1	20406893
hsa-miR-141	hsa-mir-141	12	20682048
hsa-miR-141	hsa-mir-141	12	20406893
hsa-miR-141	hsa-mir-141	12	18698484
hsa-miR-141*	hsa-mir-141	12	20682048
hsa-miR-141*	hsa-mir-141	12	20406893
hsa-miR-141*	hsa-mir-141	12	18698484
hsa-miR-144	hsa-mir-144	17	21285251
hsa-miR-144*	hsa-mir-144	17	21285251
hsa-miR-15b	hsa-mir-15b	3	20154725
hsa-miR-15b*	hsa-mir-15b	3	20154725
hsa-miR-16	hsa-mir-16-1	13	20154725
hsa-miR-16	hsa-mir-16-2	3	20154725
hsa-miR-17	hsa-mir-17	13	20406893
hsa-miR-17*	hsa-mir-17	13	20406893
hsa-miR-181a	hsa-mir-181a-2	9	21352471
hsa-miR-181a	hsa-mir-181a-1	1	21352471
hsa-miR-181a*	hsa-mir-181a-1	1	21352471
hsa-miR-181a-2*	hsa-mir-181a-2	9	21352471
hsa-miR-181b	hsa-mir-181b-1	1	21352471
hsa-miR-181b	hsa-mir-181b-2	9	21352471
hsa-miR-181c	hsa-mir-181c	19	21352471
hsa-miR-181c*	hsa-mir-181c	19	21352471
hsa-miR-181d	hsa-mir-181d	19	21352471
hsa-miR-183	hsa-mir-183	7	20406893
hsa-miR-183*	hsa-mir-183	7	20406893
hsa-miR-199a-3p	hsa-mir-199a-2	1	20400975
hsa-miR-199a-5p	hsa-mir-199a-2	1	20400975
hsa-miR-200a	hsa-mir-200a	1	21285251
hsa-miR-200a	hsa-mir-200a	1	20473948
hsa-miR-200a	hsa-mir-200a	1	18698484
hsa-miR-200a*	hsa-mir-200a	1	21285251
hsa-miR-200a*	hsa-mir-200a	1	20473948
hsa-miR-200a*	hsa-mir-200a	1	18698484
hsa-miR-200b	hsa-mir-200b	1	18698484
hsa-miR-200b*	hsa-mir-200b	1	18698484
hsa-miR-200c	hsa-mir-200c	12	20682048
hsa-miR-200c	hsa-mir-200c	12	20473948
hsa-miR-200c	hsa-mir-200c	12	20406893
hsa-miR-200c	hsa-mir-200c	12	18698484
hsa-miR-200c*	hsa-mir-200c	12	20682048
hsa-miR-200c*	hsa-mir-200c	12	20473948
hsa-miR-200c*	hsa-mir-200c	12	20406893
hsa-miR-200c*	hsa-mir-200c	12	18698484
hsa-miR-205	hsa-mir-205	1	20473948
hsa-miR-205	hsa-mir-205	1	20406893
hsa-miR-205	hsa-mir-205	1	18698484
hsa-miR-21	hsa-mir-21	17	20154725
hsa-miR-21*	hsa-mir-21	17	20154725
hsa-miR-214	hsa-mir-214	1	20400975
hsa-miR-214*	hsa-mir-214	1	20400975
hsa-miR-24	hsa-mir-24-1	9	20467044
hsa-miR-24	hsa-mir-24-2	19	20467044
hsa-miR-301a	hsa-mir-301a	17	20406893
hsa-miR-372	hsa-mir-372	19	20154725
hsa-miR-373	hsa-mir-373	19	20154725
hsa-miR-373*	hsa-mir-373	19	20154725
hsa-miR-429	hsa-mir-429	1	18698484
hsa-miR-448	hsa-mir-448	X	20798686
hsa-miR-520h	hsa-mir-520h	19	20501832

Cis-Nats regulation

Top

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
23694	mRNA	TWIST1	chr7	18928093	18928724	394	mRNA	TWIST1	chr7	18928330	18930265	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for TWIST1

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics