AutismKB 2.0

Annotation Detail for TXK


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Basic Information Top
Gene Symbol:TXK ( BTKL,MGC22473,PSCTK5,PTK4,RLK,TKL )
Gene Full Name: TXK tyrosine kinase
Band: 4p12
Quick LinksEntrez ID:7294; OMIM: 600058; Uniprot ID:TXK_HUMAN; ENSEMBL ID: ENSG00000074966; HGNC ID: 12434
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
73Nuclear localization signal (Potential).
91Phosphotyrosine (By similarity).
420Phosphotyrosine; by autocatalysis (By
Location(AA) Modifications Resource
91Phosphotyrosine (TXK)Phospho.ELM 6.0
420Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
420PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
16S-palmitoylHMM predict
17S-palmitoylHMM predict
18S-palmitoylHMM predict
19S-palmitoylHMM predict
33Phosphoserine(CK2)HMM predict
34Phosphothreonine(CK2)HMM predict
154N-linkedHMM predict
158N-linkedHMM predict
195Phosphoserine(PKG)HMM predict
196Phosphothreonine(PKC)HMM predict
196Phosphothreonine(PKA)HMM predict
208N-linkedHMM predict
340Phosphotyrosine(Jak)HMM predict
386Phosphotyrosine(INSR)HMM predict
412PhosphothreonineHMM predict
469N-linkedHMM predict
472N-linkedHMM predict
496Phosphotyrosine(SRC)HMM predict
496Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003328
  • Location:chr4 47763517-47831029
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NFkBII GM12878GSE19485 47761990 47763286 1296 880
NFkBII GM12892GSE19485 47762035 47763022 987 989
Nanog ESGSE20650 47754288 47754399 111 9174
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 47824355 47825563 1208 0
CTCF CD4GSE12889 47783975 47784201 226 0
CTCF CD4GSE12889 47806429 47806722 293 0
CTCF CD4SISSRdata 47783975 47784201 226 0
CTCF CD4SISSRdata 47806429 47806722 293 0
CTCF G2GSE9613 47781973 47782220 247 0
CTCF G2GSE9613 47806384 47806686 302 0
CTCF G2GSE9613 47824508 47825231 723 0
CTCF G2GSE9613 47826290 47826600 310 0
Gata2 K562GSE18868 47823358 47823952 594 0
Oct1 HelaGSE14283 47817528 47817559 31 0
Oct1 HelaGSE14283 47818497 47818545 48 0
P300 T30-glioblastomaGSE21026 47824461 47825341 880 0
RARA MCF7GSE15244 47810739 47811342 603 0
Rb GrowingGSE19898 47824632 47824961 329 0
Rb QuiescentGSE19898 47824630 47825018 388 0
Rb SenescentGSE19898 47824577 47825042 465 0
STAT1 HeLaGSE12783 47790491 47791675 1184 0
Sox2 hESGSE18292 47806560 47806746 186 0
hScc1 BcellGSE12603 47824321 47824952 631 0
hScc1 CdLSGSE12603 47824434 47825094 660 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018