Annotation Detail for TYK2
Basic Information Top
| Gene Symbol: | TYK2 ( JTK1 ) |
|---|---|
| Gene Full Name: | tyrosine kinase 2 |
| Band: | 19p13.2 |
| Quick Links | Entrez ID:7297; OMIM: 176941; Uniprot ID:TYK2_HUMAN; ENSEMBL ID: ENSG00000105397; HGNC ID: 12440 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 292 | Phosphotyrosine. | |
| 499 | Phosphoserine. | |
| 604 | Phosphotyrosine (By similarity). | |
| 884 | Phosphoserine. | |
| 1054 | Phosphotyrosine; by autocatalysis (By | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 292 | Phosphotyrosine | Phospho.ELM 6.0 |
| 1054 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 |
| 1054 | Phosphotyrosine (Tyk2;JAK1) | Phospho.ELM 6.0 |
| 1055 | Phosphotyrosine (Tyk2;JAK1) | Phospho.ELM 6.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 133 | O-linked | HMM predict |
| 172 | Phosphothreonine(CK2) | HMM predict |
| 262 | Phosphothreonine(PKC) | HMM predict |
| 339 | Phosphoserine(CK1) | HMM predict |
| 340 | Phosphoserine(ATM) | HMM predict |
| 433 | Phosphotyrosine(Jak) | HMM predict |
| 550 | S-palmitoyl | HMM predict |
| 551 | S-palmitoyl | HMM predict |
| 575 | N-linked | HMM predict |
| 577 | Phosphoserine(ATM) | HMM predict |
| 663 | Phosphoserine(CK1) | HMM predict |
| 819 | Phosphoserine(CDC2) | HMM predict |
| 821 | Phosphoserine(CK1) | HMM predict |
| 821 | Phosphoserine(PKC) | HMM predict |
| 821 | Phosphoserine | HMM predict |
| 846 | Phosphoserine(IKK) | HMM predict |
| 1054 | Phosphotyrosine(Jak) | HMM predict |
| 1054 | Phosphotyrosine | HMM predict |
| 1055 | Phosphotyrosine(Jak) | HMM predict |
| 1055 | Phosphotyrosine(Jak) | HMM predict |
| 1055 | Phosphotyrosine(Syk) | HMM predict |
| 1101 | Phosphoserine(ATM) | HMM predict |
| 1103 | Phosphoserine(CDK) | HMM predict |
| 1103 | Phosphoserine(ATM) | HMM predict |
- RefSeq ID: NM_003331
- Location:chr19 10322208-10352210
- strand:-
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| Fos | K562 | GSE19551 | 10351873 | 10352893 | 1020 | 173 |
| NFkBII | GM12878 | GSE19485 | 10351351 | 10353303 | 1952 | 117 |
| NFkBII | GM12892 | GSE19485 | 10351155 | 10353344 | 2189 | 39 |
| PHF8 | HeLa | GSE20725 | 10351655 | 10353114 | 1459 | 174 |
| hScc1 | Bcell | GSE12603 | 10352487 | 10352892 | 405 | 479 |
| p130 | Quiescent | GSE19898 | 10351872 | 10352831 | 959 | 141 |
| p130 | Senescent | GSE19898 | 10351866 | 10352941 | 1075 | 193 |
| p130 | shRbSenescent | GSE19898 | 10351906 | 10353129 | 1223 | 307 |
| No data |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| H3ac | HepG2 | E | 10351502 | 10352064 | 562 | 0 |
| PHF8 | 293T | GSE20725 | 10351563 | 10352824 | 1261 | 0 |
| Rb | Growing | GSE19898 | 10351903 | 10352316 | 413 | 0 |
| Rb | Quiescent | GSE19898 | 10351822 | 10352278 | 456 | 0 |
| Rb | shRbSenescence | GSE19898 | 10351892 | 10352197 | 305 | 0 |
| hScc1 | Bcell | GSE12603 | 10322094 | 10322530 | 436 | 0 |
| hScc1 | Bcell | GSE12603 | 10325611 | 10325973 | 362 | 0 |
| hScc1 | Bcell | GSE12603 | 10335706 | 10335849 | 143 | 0 |
| hScc1 | Bcell | GSE12603 | 10336436 | 10336696 | 260 | 0 |
| hScc1 | Bcell | GSE12603 | 10349825 | 10349969 | 144 | 0 |
| p130 | shRbQuiescent | GSE19898 | 10351391 | 10352705 | 1314 | 0 |
Cis-Nats regulation