AutismKB 2.0

Annotation Detail for TYRO3


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Basic Information Top
Gene Symbol:TYRO3 ( BYK,Dtk,FLJ16467,RSE,Sky,Tif )
Gene Full Name: TYRO3 protein tyrosine kinase
Band: 15q15.1
Quick LinksEntrez ID:7301; OMIM: 600341; Uniprot ID:TYRO3_HUMAN; ENSEMBL ID: ENSG00000092445; HGNC ID: 12446
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
63N-linked (GlcNAc...) (Potential).
191N-linked (GlcNAc...) (Potential).
230N-linked (GlcNAc...) (Potential).
240N-linked (GlcNAc...) (Potential).
293N-linked (GlcNAc...) (Potential).
366N-linked (GlcNAc...) (Potential).
380N-linked (GlcNAc...) (Potential).
685Phosphotyrosine (By similarity).
686Phosphotyrosine; by autocatalysis (By
Location(AA) Modifications Resource
63N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
191N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
230N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
240N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
293N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
366N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
380N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
686Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
6Phosphoserine(PKC)HMM predict
55Phosphoserine(ATM)HMM predict
90Phosphotyrosine(Jak)HMM predict
186Phosphoserine(CDC2)HMM predict
186O-linkedHMM predict
188O-linkedHMM predict
191N-linkedHMM predict
199O-linkedHMM predict
230N-linkedHMM predict
366N-linkedHMM predict
380N-linkedHMM predict
458Phosphothreonine(PKA)HMM predict
526O-linkedHMM predict
560Phosphoserine(CK2)HMM predict
733Phosphotyrosine(Syk)HMM predict
762Phosphotyrosine(SRC)HMM predict
804Phosphotyrosine(INSR)HMM predict
804Phosphotyrosine(Jak)HMM predict
849Phosphotyrosine(Jak)HMM predict
872N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006293
  • Location:chr15 39638523-39658817
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 39637201 39637548 347 1149
hScc1 BcellGSE12603 39636391 39636586 195 2035
hScc1 BcellGSE12603 39637108 39637348 240 1296
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 39660591 39660633 42 1795
Myc K562GSE19551 39660544 39660877 333 1893
Oct1 HelaGSE14283 39660591 39660628 37 1792
TFAP2C MCF7GSE21234 39665088 39665594 506 6524
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 39640991 39641277 286 0
CTCF G2GSE9613 39648391 39648638 247 0
CTCF G2GSE9613 39654545 39654796 251 0
CTCF G2GSE9613 39657642 39657808 166 0
Oct1 H2O2-HelaGSE14283 39651928 39651967 39 0
Oct1 HelaGSE14283 39651932 39651967 35 0
Rb GrowingGSE19898 39639094 39639301 207 0
Rb GrowingGSE19898 39639311 39639547 236 0
Rb QuiescentGSE19898 39639005 39639346 341 0
Rb SenescentGSE19898 39638980 39639260 280 0
Rb shRbSenescenceGSE19898 39638953 39639253 300 0
p130 QuiescentGSE19898 39639062 39639329 267 0
p130 SenescentGSE19898 39639367 39639635 268 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
8711 mRNA TYRO3 chr15 39638523 39658818 473 mRNA chr15 39653650 39654123 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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