Annotation Detail for UGDH

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Basic Information Top

Gene Symbol:	UGDH ( GDH,UDP-GlcDH,UDPGDH,UGD )
Gene Full Name:	UDP-glucose 6-dehydrogenase
Band:	4p14
Quick Links	Entrez ID:7358; OMIM: 603370; Uniprot ID:UGDH_HUMAN; ENSEMBL ID: ENSG00000109814; HGNC ID: 12525
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:4 results
Experimental PTM Sites from dbPTM:1 results
Predicted PTM Sites by profile HMM from dbPTM:8 results

Location(AA)	Modification
107	N6-acetyllysine.
173	N6-acetyllysine.
434	N6-acetyllysine.
473	Phosphotyrosine (By similarity).

Location(AA)	Modification	Resource
14	Phosphotyrosine(Jak)	HMM predict
185	Phosphothreonine(CDC2)	HMM predict
216	O-linked	HMM predict
219	Phosphoserine(CK1)	HMM predict
342	Phosphothreonine(PKA)	HMM predict
352	Phosphotyrosine(INSR)	HMM predict
386	Phosphoserine(CK2)	HMM predict
402	Phosphotyrosine(Syk)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_003359
Location:chr4 39176770-39205605
strand:-

Upstream the gene:7 results
Downstream the gene:1 results
Inside the gene:14 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FoxA1	MCF7	MACSdata	39217075	39217258	183	11561
H3K4me3	colorectal	cancer	39206374	39206697	323	930
H3ac	HepG2	E	39206266	39206697	431	876
PHF8	293T	GSE20725	39205081	39206570	1489	220
PHF8	HeLa	GSE20725	39204896	39206522	1626	104
PHF8	Hs68plusFBS	GSE20725	39204390	39206863	2473	21
p130	shRbQuiescent	GSE19898	39205731	39206150	419	335

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Oct1	H2O2-Hela	GSE14283	39172123	39172158	35	4630

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	39204998	39206053	1055	0
ER	Fulvestrant-MCF7	GSE14664	39187198	39187249	51	0
ER	MCF7	GSE19013	39192888	39193274	386	0
H3K4me3	colorectal	cancer	39203911	39204998	1087	0
H3ac	HepG2	E	39200346	39200752	406	0
H3ac	HepG2	E	39202102	39202490	388	0
H3ac	HepG2	E	39202836	39203167	331	0
H3ac	HepG2	E	39203840	39205520	1680	0
Oct1	Hela	GSE14283	39187201	39187249	48	0
P300	T30-glioblastoma	GSE21026	39192843	39193685	842	0
RNAII	Tamoxifen-MCF7	GSE14664	39187199	39187245	46	0
TAF	Hela	GSE8489	39203840	39205174	1334	0
TFAP2C	MCF7	GSE21234	39205372	39205773	401	0
hScc1	Bcell	GSE12603	39204762	39205905	1143	0

Validated miRNA targets

miR Walk:5 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-15a	hsa-mir-15a	13	18362358
hsa-miR-15a*	hsa-mir-15a	13	18362358
hsa-miR-16	hsa-mir-16-1	13	18362358
hsa-miR-16	hsa-mir-16-2	3	18362358
hsa-miR-16-1*	hsa-mir-16-1	13	18362358

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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