AutismKB 2.0

Annotation Detail for VARS


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Basic Information Top
Gene Symbol:VARS ( G7A,VARS1,VARS2 )
Gene Full Name: valyl-tRNA synthetase
Band: 6p21.33
Quick LinksEntrez ID:7407; OMIM: 192150; Uniprot ID:SYVC_HUMAN; ENSEMBL ID: ENSG00000204394; HGNC ID: 12651
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylserine.
300Phosphotyrosine.
354"HIGH" region.
420N6-acetyllysine.
423N6-acetyllysine.
645N6-acetyllysine.
866"KMSKS" region.
Location(AA) Modifications Resource
No data
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006295
  • Location:chr6 31853277-31871690
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 31871643 31871915 272 89
CTCF CD4SISSRdata 31871643 31871915 272 89
p130 SenescentGSE19898 31871728 31871952 224 150
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
PHF8 Hs68plusFBSGSE20725 31852624 31853684 1060 124
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 31854661 31856040 1379 0
CTCF G2GSE9613 31857213 31858425 1212 0
CTCF G2GSE9613 31860606 31861572 966 0
CTCF G2GSE9613 31867141 31869004 1863 0
CTCF G2GSE9613 31871296 31871896 600 0
H3ac HepG2E 31869894 31871332 1438 0
Oct1 H2O2-HelaGSE14283 31870408 31870441 33 0
Oct1 HelaGSE14283 31870408 31870442 34 0
PHF8 HeLaGSE20725 31870417 31872115 1698 0
TAF k562GSE8489 31869282 31869551 269 0
TAF k562GSE8489 31869894 31870533 639 0
hScc1 BcellGSE12603 31854661 31855014 353 0
hScc1 BcellGSE12603 31871141 31871896 755 0
hScc1 G2GSE9613 31871018 31871896 878 0
p130 shRbQuiescentGSE19898 31870310 31870713 403 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018