AutismKB 2.0

Annotation Detail for VCL


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Basic Information Top
Gene Symbol:VCL ( CMD1W,CMH15,MVCL )
Gene Full Name: vinculin
Band: 10q22.2
Quick LinksEntrez ID:7414; OMIM: 193065; Uniprot ID:VINC_HUMAN; ENSEMBL ID: ENSG00000035403; HGNC ID: 12665
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
100Phosphotyrosine (By similarity).
173N6-acetyllysine.
290Phosphoserine.
324Phosphothreonine (By similarity).
496N6-acetyllysine.
508Phosphothreonine.
537Phosphotyrosine (Potential).
604Phosphothreonine.
692Phosphotyrosine.
721Phosphoserine.
774Phosphoserine (By similarity).
822Phosphotyrosine.
1133Phosphotyrosine; by SRC-type Tyr-kinases.
Location(AA) Modifications Resource
290Phosphoserine.Swiss-Prot 53.0
507PhosphothreoninePhospho.ELM 6.0
508Phosphothreonine.Swiss-Prot 53.0
537Phosphotyrosine (Potential).Swiss-Prot 53.0
604Phosphothreonine.Swiss-Prot 53.0
721Phosphoserine.Swiss-Prot 53.0
822Phosphotyrosine (Probable).Swiss-Prot 53.0
1100Phosphoserine (PKC alpha)Phospho.ELM 6.0
1112Phosphoserine (PKC alpha)Phospho.ELM 6.0
1132PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
97Phosphoserine(ATM)HMM predict
100Phosphotyrosine(Syk)HMM predict
100Phosphotyrosine(Abl)HMM predict
101Phosphoserine(IKK)HMM predict
169Phosphothreonine(PKC)HMM predict
183PhosphothreonineHMM predict
197Phosphothreonine(PKC)HMM predict
231N-linkedHMM predict
275Phosphoserine(CK1)HMM predict
288PhosphoserineHMM predict
290Phosphoserine(CDC2)HMM predict
346Phosphoserine(IKK)HMM predict
346Phosphoserine(CDC2)HMM predict
506N-linkedHMM predict
600Phosphoserine(CK1)HMM predict
604Phosphothreonine(CDC2)HMM predict
654N-linkedHMM predict
692Phosphotyrosine(EGFR)HMM predict
774Phosphoserine(CK2)HMM predict
787Phosphoserine(CK2)HMM predict
791Phosphoserine(CK1)HMM predict
807N-linkedHMM predict
816Phosphoserine(IKK)HMM predict
913Phosphoserine(PKG)HMM predict
949SulfotyrosineHMM predict
949Phosphotyrosine(Syk)HMM predict
1011Phosphothreonine(PKC)HMM predict
1078N-linkedHMM predict
1080Phosphoserine(CK2)HMM predict
1084Phosphoserine(CK1)HMM predict
1084Phosphoserine(CK2)HMM predict
1105Phosphothreonine(PKC)HMM predict
1123Phosphothreonine(PKC)HMM predict
1130Phosphothreonine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003373
  • Location:chr10 75427877-75549917
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 75427040 75428290 1250 213
NRSF JurkatSISSRdata 75421708 75421896 188 6076
SRF HelaGSE8489 75427132 75427525 393 549
SRF k562GSE8489 75427132 75427492 360 566
TFAP2C MCF7GSE21234 75427589 75428145 556 11
p130 shRbSenescentGSE19898 75427255 75428150 895 175
p63 keratinocytesGSE17611 75412634 75413508 874 14807
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 75488505 75488666 161 0
CTCF CD4GSE12889 75511056 75511327 271 0
CTCF CD4GSE12889 75533416 75533602 186 0
CTCF CD4SISSRdata 75488505 75488666 161 0
CTCF CD4SISSRdata 75511056 75511327 271 0
CTCF CD4SISSRdata 75533416 75533602 186 0
FOXA1 MCF7GSE15244 75526855 75528025 1170 0
FoxA1 MCF7MACSdata 75485813 75486047 234 0
FoxA1 MCF7MACSdata 75527536 75527889 353 0
H3K4me3 colorectalcancer 75429727 75429896 169 0
H3ac HepG2E 75430548 75431677 1129 0
NFkBII GM12878GSE19485 75546875 75548339 1464 0
NFkBII GM12892GSE19485 75547048 75548348 1300 0
NFkBII GM18505GSE19485 75547130 75548227 1097 0
Oct1 HelaGSE14283 75527845 75527880 35 0
Oct1 HelaGSE14283 75543205 75543240 35 0
PHF8 293TGSE20725 75427748 75428489 741 0
PHF8 HeLaGSE20725 75427467 75428665 1198 0
RARG MCF7GSE15244 75525348 75525551 203 0
Rb QuiescentGSE19898 75428678 75428853 175 0
Rb QuiescentGSE19898 75429167 75429500 333 0
Rb SenescentGSE19898 75428626 75429022 396 0
SRF k562GSE8489 75450943 75451830 887 0
TAF HelaGSE8489 75450630 75450781 151 0
TAF k562GSE8489 75429178 75429896 718 0
TAF k562GSE8489 75441714 75442290 576 0
TFAP2C MCF7GSE21234 75524069 75524314 245 0
hScc1 BcellGSE12603 75427722 75428142 420 0
hScc1 BcellGSE12603 75428510 75428875 365 0
hScc1 BcellGSE12603 75511010 75511372 362 0
hScc1 BcellGSE12603 75533321 75534085 764 0
hScc1 CdLSGSE12603 75510847 75511618 771 0
hScc1 CdLSGSE12603 75532967 75534221 1254 0
p130 QuiescentGSE19898 75436988 75437205 217 0
p130 SenescentGSE19898 75457489 75457791 302 0
p130 shRbQuiescentGSE19898 75428562 75428971 409 0
p63 keratinocytesGSE17611 75529024 75530298 1274 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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