AutismKB 2.0

Annotation Detail for WHSC1


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Basic Information Top
Gene Symbol:WHSC1 ( FLJ23286,KIAA1090,MGC176638,MMSET,NSD2,REIIBP,TRX5,WHS )
Gene Full Name: Wolf-Hirschhorn syndrome candidate 1
Band: 4p16.3
Quick LinksEntrez ID:7468; OMIM: 602952; Uniprot ID:NSD2_HUMAN; ENSEMBL ID: ENSG00000109685; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
102Phosphoserine.
110Phosphothreonine.
114Phosphothreonine.
115Phosphothreonine.
121Phosphoserine.
376Phosphoserine.
437Phosphoserine.
544Phosphothreonine.
779N6-acetyllysine.
781N6-acetyllysine.
Location(AA) Modifications Resource
544Phosphothreonine.Swiss-Prot 53.0
544PhosphothreoninePhospho.ELM 6.0
Location(AA) Modification Resource
8Phosphoserine(CDC2)HMM predict
56Phosphoserine(CK1)HMM predict
110Phosphothreonine(MAPK)HMM predict
113N-linkedHMM predict
115Phosphothreonine(CDC2)HMM predict
119N-linkedHMM predict
152Phosphoserine(ATM)HMM predict
152Phosphoserine(CK2)HMM predict
172Phosphoserine(PKG)HMM predict
194Phosphoserine(CDC2)HMM predict
206Phosphoserine(IKK)HMM predict
334Phosphoserine(MAPK)HMM predict
369Phosphoserine(PKG)HMM predict
422Phosphothreonine(CDC2)HMM predict
422Phosphothreonine(CDK)HMM predict
437Phosphoserine(CDC2)HMM predict
444Phosphothreonine(PKA)HMM predict
444Phosphothreonine(PKC)HMM predict
445Phosphothreonine(PKA)HMM predict
479Phosphoserine(CK2)HMM predict
492Phosphoserine(IKK)HMM predict
527N-linkedHMM predict
544Phosphothreonine(MAPK)HMM predict
551Phosphothreonine(PKA)HMM predict
551Phosphothreonine(PKC)HMM predict
566O-linkedHMM predict
571Phosphoserine(PKB)HMM predict
572Phosphotyrosine(SRC)HMM predict
580Phosphoserine(CK1)HMM predict
583Phosphoserine(IKK)HMM predict
604O-linkedHMM predict
605Phosphothreonine(PKC)HMM predict
618Phosphoserine(CDC2)HMM predict
618Phosphoserine(IKK)HMM predict
618Phosphoserine(CDK)HMM predict
620Phosphoserine(IKK)HMM predict
631Phosphoserine(ATM)HMM predict
631Phosphoserine(CDC2)HMM predict
637O-linkedHMM predict
639Phosphoserine(ATM)HMM predict
639Phosphoserine(CDC2)HMM predict
641Phosphotyrosine(SRC)HMM predict
641Phosphotyrosine(INSR)HMM predict
641Phosphotyrosine(Syk)HMM predict
652Phosphoserine(CK2)HMM predict
663Phosphothreonine(PKC)HMM predict
682S-palmitoylHMM predict
686S-palmitoylHMM predict
687S-palmitoylHMM predict
771N-linkedHMM predict
774N-linkedHMM predict
830N-linkedHMM predict
846S-palmitoylHMM predict
849S-palmitoylHMM predict
928Phosphotyrosine(Jak)HMM predict
929Phosphotyrosine(Jak)HMM predict
944MethylarginineHMM predict
981Phosphothreonine(PKC)HMM predict
1041S-palmitoylHMM predict
1135N-linkedHMM predict
1141N-linkedHMM predict
1147N-linkedHMM predict
1197N-linkedHMM predict
1221Phosphothreonine(PKC)HMM predict
1225Phosphothreonine(PKC)HMM predict
1299S-palmitoylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001042424
  • Location:chr4 1842920-1953725
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 1835691 1836553 862 6799
CTCF G2GSE9613 1837737 1838432 695 4836
CTCF G2GSE9613 1842207 1842448 241 593
H3ac HepG2E 1835094 1835803 709 7472
PHF8 HeLaGSE20725 1841477 1842655 1178 855
PHF8 Hs68minusFBSGSE20725 1841776 1842888 1112 589
Rb QuiescentGSE19898 1842109 1842404 295 664
USF1 HepG2E 1835094 1835658 564 7545
USF2 HepG2E 1835094 1835803 709 7472
hScc1 BcellGSE12603 1836315 1836553 238 6487
hScc1 BcellGSE12603 1841691 1842448 757 851
p130 QuiescentGSE19898 1842720 1842988 268 67
p130 SenescentGSE19898 1842691 1842894 203 128
p130 shRbSenescentGSE19898 1842585 1842896 311 180
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 1843599 1844007 408 0
Gata2 K562GSE18868 1854215 1854957 742 0
H3ac HepG2E 1843726 1844589 863 0
Myc hESGSE17917 1842979 1843307 328 0
hScc1 BcellGSE12603 1843599 1843840 241 0
hScc1 G2GSE9613 1843048 1843279 231 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
19319 mRNA WHSC1 chr4 1861739 1951161 658 EST chr4 1948675 1949341Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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