Annotation Detail for WNT2

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Basic Information Top

Gene Symbol:	WNT2 ( INT1L1,IRP )
Gene Full Name:	wingless-type MMTV integration site family member 2
Band:	7q31.2
Quick Links	Entrez ID:7472; OMIM: 147870; Uniprot ID:WNT2_HUMAN; ENSEMBL ID: ENSG00000105989; HGNC ID: 12780
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:1 results
Experimental PTM Sites from dbPTM:1 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

Location(AA)	Modification
295	N-linked (GlcNAc...) (Potential).

Location(AA)	Modification	Resource
24	N-linked	HMM predict
66	Phosphoserine(PKG)	HMM predict
66	Phosphoserine(ATM)	HMM predict
128	Phosphoserine(ATM)	HMM predict
128	Phosphoserine(PKG)	HMM predict
295	N-linked	HMM predict
313	Phosphotyrosine(Jak)	HMM predict
324	S-palmitoyl	HMM predict
331	S-palmitoyl	HMM predict
332	S-palmitoyl	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_003391
Location:chr7 116704517-116750578
strand:-

Upstream the gene:4 results
Downstream the gene:2 results
Inside the gene:8 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3K27me3	colorectal	cancer	116750589	116751566	977	499
Oct1	Hela	GSE14283	116752624	116752690	66	2079
p130	shRbQuiescent	GSE19898	116751420	116751957	537	1110
p130	shRbSenescent	GSE19898	116751448	116751910	462	1101

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	116701642	116701842	200	2776
p63	keratinocytes	GSE17611	116700971	116701898	927	3083

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	116750348	116750589	241	0
ER	MCF7	GSE19013	116706961	116707679	718	0
H3K27me3	colorectal	cancer	116748158	116748582	424	0
H3K27me3	colorectal	cancer	116749254	116750145	891	0
Nanog	hES	GSE18292	116739021	116739591	570	0
Oct1	H2O2-Hela	GSE14283	116748422	116748457	35	0
Oct1	Hela	GSE14283	116748422	116748457	35	0
p63	keratinocytes	GSE17611	116723218	116724053	835	0

Validated miRNA targets

miR Walk:5 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-155	hsa-mir-155	21	21130073
hsa-miR-155*	hsa-mir-155	21	21130073
hsa-miR-320d	hsa-mir-320d-1	13	21130073
hsa-miR-320d	hsa-mir-320d-2	X	21130073
hsa-miR-429	hsa-mir-429	1	21130073

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
24536	EST		chr7	116534921	116556240	21319	mRNA	WNT2	chr7	116511232	116557294	Non-exonic Bidirectional (NOB) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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