AutismKB 2.0

Annotation Detail for WRN


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Basic Information Top
Gene Symbol:WRN ( DKFZp686C2056,RECQ3,RECQL2,RECQL3 )
Gene Full Name: Werner syndrome, RecQ helicase-like
Band: 8p12
Quick LinksEntrez ID:7486; OMIM: 604611; Uniprot ID:WRN_HUMAN; ENSEMBL ID: ENSG00000165392; HGNC ID: 12791
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
426Phosphoserine.
453Phosphoserine.
467Phosphoserine.
671DEAH box.
1058Phosphoserine.
1133Phosphoserine.
1141Phosphoserine.
Location(AA) Modifications Resource
1141Phosphoserine (ATM)Phospho.ELM 6.0
1292Phosphoserine (ATM)Phospho.ELM 6.0
Location(AA) Modification Resource
199N-linkedHMM predict
282Phosphoserine(PKG)HMM predict
282Phosphoserine(PKA)HMM predict
409Phosphoserine(CK2)HMM predict
426Phosphoserine(ATM)HMM predict
432N-linkedHMM predict
436SulfotyrosineHMM predict
459N-linkedHMM predict
463SulfotyrosineHMM predict
703O-linkedHMM predict
705O-linkedHMM predict
709Phosphoserine(CK2)HMM predict
743Phosphothreonine(PKA)HMM predict
777Phosphothreonine(PKA)HMM predict
849Phosphotyrosine(Syk)HMM predict
935S-palmitoylHMM predict
936S-palmitoylHMM predict
1056Phosphothreonine(PKC)HMM predict
1058Phosphoserine(ATM)HMM predict
1084O-linkedHMM predict
1100Phosphothreonine(PKC)HMM predict
1139Phosphoserine(CK1)HMM predict
1140O-linkedHMM predict
1141Phosphoserine(ATM)HMM predict
1258Phosphoserine(IKK)HMM predict
1292Phosphoserine(ATM)HMM predict
1309Phosphothreonine(MAPK)HMM predict
1384Phosphoserine(CDC2)HMM predict
1388Phosphoserine(CK1)HMM predict
1388Phosphoserine(PKG)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000553
  • Location:chr8 31010319-31150817
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 31162392 31162646 254 11702
CTCF CD4SISSRdata 31162392 31162646 254 11702
CTCF G2GSE9613 31162303 31162807 504 11738
CTCF G2GSE9613 31166278 31166426 148 15535
ER Fulvestrant-MCF7GSE14664 31165041 31165075 34 14241
FOXA1 MCF7GSE15244 31162628 31162985 357 11989
Oct1 HelaGSE14283 31160762 31160814 52 9971
TFAP2C MCF7GSE21234 31162745 31163250 505 12180
hScc1 BcellGSE12603 31162339 31162917 578 11811
hScc1 CdLSGSE12603 31162156 31162953 797 11737
hScc1 G2GSE9613 31162259 31162953 694 11789
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 31126282 31126554 272 0
CTCF CD4GSE12889 31084560 31084752 192 0
CTCF CD4SISSRdata 31084560 31084752 192 0
CTCF G2GSE9613 31010643 31011150 507 0
ER Fulvestrant-MCF7GSE14664 31084084 31084117 33 0
ETS1 JurkatGSE17954 31010220 31011379 1159 0
FOXA1 MCF7GSE15244 31010896 31011430 534 0
Fos K562GSE19551 31011271 31012160 889 0
H3K4me3 colorectalcancer 31011188 31011644 456 0
H3ac HepG2E 31011045 31011644 599 0
H3ac HepG2E 31012202 31012750 548 0
Nanog ESGSE20650 31108494 31108841 347 0
Oct1 H2O2-HelaGSE14283 31030358 31030386 28 0
Oct1 H2O2-HelaGSE14283 31082498 31082524 26 0
Oct1 HelaGSE14283 31084085 31084120 35 0
PHF8 293TGSE20725 31010386 31011543 1157 0
PHF8 Hs68minusFBSGSE20725 31010843 31011570 727 0
PHF8 Hs68plusFBSGSE20725 31010472 31011613 1141 0
Rb GrowingGSE19898 31010737 31011120 383 0
Rb QuiescentGSE19898 31010811 31011385 574 0
Rb SenescentGSE19898 31010425 31011312 887 0
TAF HelaGSE8489 31011045 31011644 599 0
TAF HelaGSE8489 31012129 31012392 263 0
TAF k562GSE8489 31010930 31011644 714 0
hScc1 BcellGSE12603 31010849 31011114 265 0
hScc1 CdLSGSE12603 31084419 31084895 476 0
p130 QuiescentGSE19898 31010815 31011275 460 0
p130 SenescentGSE19898 31010793 31011383 590 0
p130 shRbQuiescentGSE19898 31010506 31011401 895 0
p130 shRbSenescentGSE19898 31010800 31011409 609 0
p63 keratinocytesGSE17611 31040292 31040732 440 0
p63 keratinocytesGSE17611 31149366 31150163 797 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
25259 mRNA WRN chr8 31010319 31150818 454 mRNA PURG chr8 30972862 31010773Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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