AutismKB 2.0

Annotation Detail for XRCC4


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Basic Information Top
Gene Symbol:XRCC4 ( - )
Gene Full Name: X-ray repair complementing defective repair in Chinese hamster cells 4
Band: 5q14.2
Quick LinksEntrez ID:7518; OMIM: 194363; Uniprot ID:XRCC4_HUMAN; ENSEMBL ID: ENSG00000152422; HGNC ID: 12831
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
232Phosphoserine (By similarity).
233Phosphothreonine (By similarity).
260Phosphoserine; by PRKDC.
320Phosphoserine; by PRKDC.
327Phosphoserine.
328Phosphoserine.
Location(AA) Modifications Resource
193PhosphoserinePhospho.ELM 6.0
260Phosphoserine (by PRKDC).Swiss-Prot 53.0
260PhosphoserinePhospho.ELM 6.0
304PhosphoserinePhospho.ELM 6.0
315PhosphoserinePhospho.ELM 6.0
320Phosphoserine (by PRKDC).Swiss-Prot 53.0
320PhosphoserinePhospho.ELM 6.0
323PhosphothreoninePhospho.ELM 6.0
327PhosphoserinePhospho.ELM 6.0
328PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
6Phosphoserine(PKG)HMM predict
48Phosphoserine(CAMK2)HMM predict
48Phosphoserine(CK2)HMM predict
53PhosphoserineHMM predict
53Phosphoserine(ATM)HMM predict
53Phosphoserine(CK1)HMM predict
53Phosphoserine(CK2)HMM predict
87N-linkedHMM predict
229Phosphotyrosine(EGFR)HMM predict
232Phosphoserine(CK2)HMM predict
237Phosphoserine(CK1)HMM predict
239N-linkedHMM predict
309Phosphoserine(CK1)HMM predict
320Phosphoserine(CK1)HMM predict
326N-linkedHMM predict
327Phosphoserine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003401
  • Location:chr5 82409072-82685332
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 82408649 82409398 749 49
GABP k562GSE8489 82407342 82410753 3411 25
PHF8 Hs68minusFBSGSE20725 82408302 82409800 1498 22
TAF HelaGSE8489 82408117 82409910 1793 59
p130 shRbQuiescentGSE19898 82408411 82409631 1220 52
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Myc K562GSE19551 82692112 82692490 378 6969
Nanog ESGSE20650 82686245 82687140 895 1360
Nanog hESGSE18292 82686513 82687182 669 1515
Oct1 HelaGSE14283 82685586 82685638 52 280
Oct4 hESGSE21916 82686131 82687033 902 1250
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 82408546 82409729 1183 0
ER E2-MCF7GSE14664 82427555 82427588 33 0
ER Fulvestrant-MCF7GSE14664 82427555 82427589 34 0
ETS1 JurkatGSE17954 82408372 82409923 1551 0
FOXA1 MCF7GSE15244 82416096 82417131 1035 0
FOXA1 MCF7GSE15244 82596772 82597337 565 0
Fos K562GSE19551 82427520 82427965 445 0
FoxA1 MCF7MACSdata 82416618 82417010 392 0
FoxA1 MCF7MACSdata 82456205 82456473 268 0
FoxA1 MCF7MACSdata 82596655 82597183 528 0
LIN54 G0GSE7516 82408546 82409832 1286 0
LIN9 G0GSE7516 82408471 82410393 1922 0
LIN9 SGSE7516 82408471 82410168 1697 0
Myc K562GSE19551 82434231 82434551 320 0
Oct1 H2O2-HelaGSE14283 82435025 82435057 32 0
Oct1 H2O2-HelaGSE14283 82492635 82492677 42 0
Oct1 H2O2-HelaGSE14283 82494587 82494619 32 0
Oct1 H2O2-HelaGSE14283 82535767 82535802 35 0
Oct1 H2O2-HelaGSE14283 82548640 82548667 27 0
Oct1 H2O2-HelaGSE14283 82587357 82587389 32 0
Oct1 HelaGSE14283 82427555 82427589 34 0
Oct1 HelaGSE14283 82435025 82435058 33 0
Oct1 HelaGSE14283 82492644 82492676 32 0
Oct1 HelaGSE14283 82494587 82494623 36 0
Oct1 HelaGSE14283 82535765 82535850 85 0
Oct1 HelaGSE14283 82587357 82587390 33 0
Oct1 HelaGSE14283 82588096 82588134 38 0
P300 T30-glioblastomaGSE21026 82596775 82597449 674 0
PHF8 HeLaGSE20725 82408451 82409802 1351 0
PHF8 Hs68plusFBSGSE20725 82408285 82409928 1643 0
RNAII Tamoxifen-MCF7GSE14664 82594126 82594216 90 0
Rb GrowingGSE19898 82409002 82409158 156 0
TAF HelaGSE8489 82598727 82598917 190 0
p130 SenescentGSE19898 82408634 82409709 1075 0
p130 shRbSenescentGSE19898 82408557 82409599 1042 0
p130 G0GSE7516 82408471 82409797 1326 0
p63 keratinocytesGSE17611 82432840 82433706 866 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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