AutismKB 2.0

Annotation Detail for YES1


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Basic Information Top
Gene Symbol:YES1 ( HsT441,P61-YES,Yes,c-yes )
Gene Full Name: v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Band: 18p11.32
Quick LinksEntrez ID:7525; OMIM: 164880; Uniprot ID:YES_HUMAN; ENSEMBL ID: ENSG00000176105; HGNC ID: 12841
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
11Phosphoserine.
21Phosphothreonine.
26Phosphoserine.
32Phosphotyrosine.
40Phosphoserine.
111Phosphoserine.
194Phosphotyrosine.
195Phosphoserine.
222Phosphotyrosine.
223Phosphotyrosine.
336Phosphotyrosine.
345Phosphotyrosine.
426Phosphotyrosine; by autocatalysis.
446Phosphotyrosine.
537Phosphotyrosine.
Location(AA) Modifications Resource
2N-myristoyl glycine (By similarity).Swiss-Prot 53.0
425Phosphotyrosine (Yes)Phospho.ELM 6.0
426Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
536PhosphotyrosinePhospho.ELM 6.0
537Phosphotyrosine.Swiss-Prot 53.0
Location(AA) Modification Resource
11Phosphoserine(CDC2)HMM predict
21Phosphothreonine(MAPK)HMM predict
26O-linkedHMM predict
26O-linkedHMM predict
38O-linkedHMM predict
40Phosphoserine(CDC2)HMM predict
40Phosphoserine(IKK)HMM predict
45O-linkedHMM predict
45Phosphoserine(CDC2)HMM predict
46O-linkedHMM predict
79O-linkedHMM predict
79O-linkedHMM predict
79Phosphoserine(ATM)HMM predict
122N-linkedHMM predict
123N-linkedHMM predict
141Phosphotyrosine(INSR)HMM predict
141Phosphotyrosine(EGFR)HMM predict
187Phosphoserine(CK2)HMM predict
252Phosphothreonine(PKA)HMM predict
257O-linkedHMM predict
257O-linkedHMM predict
297N-linkedHMM predict
306Phosphothreonine(PKC)HMM predict
336Phosphotyrosine(Jak)HMM predict
345Phosphotyrosine(Jak)HMM predict
345Phosphotyrosine(SRC)HMM predict
345Phosphotyrosine(INSR)HMM predict
345Phosphotyrosine(EGFR)HMM predict
345SulfotyrosineHMM predict
367Phosphotyrosine(Jak)HMM predict
426Phosphotyrosine(INSR)HMM predict
426Phosphotyrosine(Syk)HMM predict
426PhosphotyrosineHMM predict
537Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005433
  • Location:chr18 711593-802326
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 822147 822482 335 19988
GABP k562GSE8489 802756 804788 2032 1446
H3ac HepG2E 822147 822482 335 19988
KLF4 hESGSE17917 802312 802478 166 69
PHF8 293TGSE20725 801620 803053 1433 10
PHF8 Hs68plusFBSGSE20725 801573 803428 1855 174
Sox2 hESGSE18292 821030 821253 223 18815
hScc1 BcellGSE12603 801827 802894 1067 34
hScc1 BcellGSE12603 820525 821126 601 18499
hScc1 CdLSGSE12603 820557 821126 569 18515
hScc1 G2GSE9613 820525 821126 601 18499
p130 QuiescentGSE19898 802558 803171 613 538
p130 shRbQuiescentGSE19898 802616 803504 888 734
p130 shRbSenescentGSE19898 820531 820755 224 18317
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 731838 732229 391 0
CTCF CD4SISSRdata 731838 732229 391 0
CTCF G2GSE9613 731838 732044 206 0
GABP k562GSE8489 800047 801627 1580 0
H3K4me3 colorectalcancer 800434 801791 1357 0
H3ac HepG2E 800047 801903 1856 0
PHF8 HeLaGSE20725 801399 802997 1598 0
TAF HelaGSE8489 800047 801672 1625 0
TAF k562GSE8489 800047 801627 1580 0
TFAP2C MCF7GSE21234 760487 760774 287 0
hScc1 BcellGSE12603 731838 732227 389 0
hScc1 CdLSGSE12603 731838 732299 461 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-145 hsa-mir-145 5 20098684
hsa-miR-145* hsa-mir-145 5 20098684
hsa-miR-17 hsa-mir-17 13 19734348
hsa-miR-17* hsa-mir-17 13 19734348
hsa-miR-181a hsa-mir-181a-2 9 21274007
hsa-miR-181a hsa-mir-181a-1 1 21274007
hsa-miR-205 hsa-mir-205 1 21330408
hsa-miR-374a hsa-mir-374a X 21274007
hsa-miR-374a* hsa-mir-374a X 21274007
hsa-miR-375 hsa-mir-375 2 19734348
hsa-miR-519a hsa-mir-519a-1 19 21274007
hsa-miR-519a hsa-mir-519a-2 19 21274007
hsa-miR-630 hsa-mir-630 15 21274007
hsa-miR-93 hsa-mir-93 7 19734348
hsa-miR-93* hsa-mir-93 7 19734348
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
11858 HTC chr18 725745 727455 154 mRNA YES1 chr18 711591 802327Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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