AutismKB 2.0

Annotation Detail for YWHAE


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Basic Information Top
Gene Symbol:YWHAE ( 14-3-3E,FLJ45465,FLJ53559,KCIP-1,MDCR,MDS )
Gene Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Band: 17p13.3
Quick LinksEntrez ID:7531; OMIM: 605066; Uniprot ID:1433E_HUMAN; ENSEMBL ID: ENSG00000108953; HGNC ID: 12851
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
38Phosphothreonine.
50N6-acetyllysine.
69N6-acetyllysine.
118N6-acetyllysine.
123N6-acetyllysine.
210Phosphoserine.
Location(AA) Modifications Resource
1N-acetylmethionine.Swiss-Prot 53.0
Location(AA) Modification Resource
20SulfotyrosineHMM predict
59Phosphoserine(PKA)HMM predict
59Phosphoserine(PKB)HMM predict
131Phosphotyrosine(Syk)HMM predict
176N-linkedHMM predict
187Phosphoserine(CDK)HMM predict
187Phosphoserine(CDC2)HMM predict
210Phosphoserine(CK1)HMM predict
214Phosphotyrosine(Syk)HMM predict
227N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006761
  • Location:chr17 1194594-1250266
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 1250228 1250592 364 144
PHF8 293TGSE20725 1249619 1250932 1313 9
Rb QuiescentGSE19898 1250077 1250545 468 45
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 1182461 1182889 428 11920
CTCF CD4SISSRdata 1182461 1182889 428 11920
CTCF HelaGSE12889 1182604 1182954 350 11816
CTCF G2GSE9613 1181768 1182085 317 12668
CTCF G2GSE9613 1182468 1182854 386 11934
NFkBII GM12892GSE19485 1192158 1193392 1234 1820
hScc1 BcellGSE12603 1181873 1182106 233 12605
hScc1 BcellGSE12603 1182468 1182854 386 11934
hScc1 CdLSGSE12603 1182468 1182854 386 11934
hScc1 G2GSE9613 1182468 1182854 386 11934
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 1215547 1215823 276 0
CTCF CD4SISSRdata 1215547 1215823 276 0
CTCF G2GSE9613 1215547 1215850 303 0
ETS1 JurkatGSE17954 1249575 1250617 1042 0
H3K4me3 colorectalcancer 1248236 1249295 1059 0
H3ac HepG2E 1247257 1249644 2387 0
NFkBII GM18526GSE19485 1249669 1250794 1125 0
P300 T30-glioblastomaGSE21026 1249278 1250693 1415 0
PHF8 HeLaGSE20725 1249192 1251080 1888 0
PHF8 Hs68minusFBSGSE20725 1249462 1250620 1158 0
Rb SenescentGSE19898 1249811 1250644 833 0
TAF HelaGSE8489 1247288 1249349 2061 0
TAF k562GSE8489 1247257 1249383 2126 0
hScc1 BcellGSE12603 1215459 1215850 391 0
hScc1 BcellGSE12603 1249383 1250622 1239 0
hScc1 CdLSGSE12603 1215267 1215850 583 0
hScc1 CdLSGSE12603 1249225 1250622 1397 0
p130 SenescentGSE19898 1249311 1250638 1327 0
p130 shRbQuiescentGSE19898 1249715 1250628 913 0
p130 shRbSenescentGSE19898 1249323 1250642 1319 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018