Annotation Detail for ZAP70

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Basic Information Top

Gene Symbol:	ZAP70 ( FLJ17670,FLJ17679,SRK,STD,TZK,ZAP-70 )
Gene Full Name:	zeta-chain (TCR) associated protein kinase 70kDa
Band:	2q11.2
Quick Links	Entrez ID:7535; OMIM: 176947; Uniprot ID:ZAP70_HUMAN; ENSEMBL ID: ENSG00000115085; HGNC ID: 12858
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:8 results
Experimental PTM Sites from dbPTM:16 results
Predicted PTM Sites by profile HMM from dbPTM:28 results

Location(AA)	Modification
248	Phosphotyrosine.
289	Phosphoserine.
292	Phosphotyrosine.
315	Phosphotyrosine.
319	Phosphotyrosine.
492	Phosphotyrosine; by autocatalysis.
493	Phosphotyrosine.
603	N6-acetyllysine.

Location(AA)	Modifications	Resource
126	Phosphotyrosine (ZAP70)	Phospho.ELM 6.0
248	Phosphotyrosine.	Swiss-Prot 53.0
248	Phosphotyrosine	Phospho.ELM 6.0
289	Phosphoserine.	Swiss-Prot 53.0
289	Phosphoserine	Phospho.ELM 6.0
292	Phosphotyrosine.	Swiss-Prot 53.0
292	Phosphotyrosine (Lck;ZAP70)	Phospho.ELM 6.0
315	Phosphotyrosine.	Swiss-Prot 53.0
315	Phosphotyrosine (ZAP70)	Phospho.ELM 6.0
319	Phosphotyrosine (Abl)	Phospho.ELM 6.0
319	Phosphotyrosine.	Swiss-Prot 53.0
474	Phosphotyrosine (Lck)	Phospho.ELM 6.0
492	Phosphotyrosine (by autocatalysis).	Swiss-Prot 53.0
492	Phosphotyrosine (Lck;ZAP70)	Phospho.ELM 6.0
493	Phosphotyrosine.	Swiss-Prot 53.0
493	Phosphotyrosine (Lck;ZAP70)	Phospho.ELM 6.0

Location(AA)	Modification	Resource
66	N-linked	HMM predict
144	Phosphoserine(ATM)	HMM predict
214	Phosphoserine(ATM)	HMM predict
256	N-linked	HMM predict
261	N-linked	HMM predict
263	O-linked	HMM predict
275	O-linked	HMM predict
278	Phosphothreonine(CDK)	HMM predict
286	Phosphothreonine(PKA)	HMM predict
292	Phosphotyrosine(INSR)	HMM predict
301	Phosphoserine(CDC2)	HMM predict
315	Phosphotyrosine(INSR)	HMM predict
315	Phosphotyrosine(Syk)	HMM predict
315	Phosphotyrosine(SRC)	HMM predict
315	Phosphotyrosine	HMM predict
317	Phosphoserine(ATM)	HMM predict
319	Phosphotyrosine(Syk)	HMM predict
319	Phosphotyrosine(SRC)	HMM predict
320	Phosphoserine(ATM)	HMM predict
320	Phosphoserine(CK2)	HMM predict
320	Phosphoserine(CK2)	HMM predict
446	Phosphoserine(CAMK2)	HMM predict
492	Phosphotyrosine	HMM predict
493	Phosphotyrosine(Syk)	HMM predict
528	O-linked	HMM predict
540	Phosphotyrosine(Syk)	HMM predict
610	Phosphoserine(CDK)	HMM predict
618	S-farnesyl	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001079
Location:chr2 97696462-97722754
strand:+

Upstream the gene:20 results
Downstream the gene:0 results
Inside the gene:13 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	97680252	97680581	329	16046
CTCF	CD4	GSE12889	97692857	97693115	258	3477
CTCF	CD4	SISSRdata	97680252	97680581	329	16046
CTCF	CD4	SISSRdata	97692857	97693115	258	3477
CTCF	Jurkat	GSE12889	97680274	97680508	234	16072
CTCF	Jurkat	GSE12889	97692756	97693081	325	3544
CTCF	G2	GSE9613	97680019	97680582	563	16162
CTCF	G2	GSE9613	97682530	97683578	1048	13409
CTCF	G2	GSE9613	97692604	97693029	425	3646
CTCF	G2	GSE9613	97695391	97696221	830	657
Fos	K562	GSE19551	97691507	97691846	339	4786
Gata2	K562	GSE18868	97693499	97694349	850	2539
Myc	K562	GSE19551	97682906	97683473	567	13273
hScc1	Bcell	GSE12603	97679982	97680582	600	16181
hScc1	Bcell	GSE12603	97683187	97683578	391	13080
hScc1	CdLS	GSE12603	97679982	97680582	600	16181
hScc1	CdLS	GSE12603	97683048	97683578	530	13150
hScc1	G2	GSE9613	97679905	97680582	677	16219
hScc1	G2	GSE9613	97682983	97683578	595	13182
p130	Senescent	GSE19898	97683092	97683276	184	13279

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CBP	Jurkat	GSE17954	97699322	97703217	3895
CTCF	G2	GSE9613	97696845	97697162	317
CTCF	G2	GSE9613	97699399	97699991	592
CTCF	G2	GSE9613	97702210	97702426	216
CTCF	G2	GSE9613	97706717	97707528	811
CTCF	G2	GSE9613	97707794	97708021	227
CTCF	G2	GSE9613	97708652	97709140	488
CTCF	G2	GSE9613	97715368	97715952	584
Nanog	ES	GSE20650	97703535	97704115	580
Nanog	hES	GSE18292	97703805	97704052	247
Oct4	hES	GSE21916	97703466	97704045	579
Sox2	hES	GSE18292	97703855	97704173	318
hScc1	Bcell	GSE12603	97702210	97702567	357

Validated miRNA targets

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miR Walk:88 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-146a	hsa-mir-146a	5	20011700
hsa-miR-146a	hsa-mir-146a	5	19717645
hsa-miR-146a*	hsa-mir-146a	5	20011700
hsa-miR-146a*	hsa-mir-146a	5	19717645
hsa-miR-148a	hsa-mir-148a	7	19717645
hsa-miR-148a*	hsa-mir-148a	7	19717645
hsa-miR-150	hsa-mir-150	19	18348159
hsa-miR-150*	hsa-mir-150	19	18348159
hsa-miR-151-3p	hsa-mir-151	8	19717645
hsa-miR-155	hsa-mir-155	21	19717645
hsa-miR-155	hsa-mir-155	21	18348159
hsa-miR-155*	hsa-mir-155	21	19717645
hsa-miR-155*	hsa-mir-155	21	18348159
hsa-miR-15a	hsa-mir-15a	13	21205967
hsa-miR-15a	hsa-mir-15a	13	18348159
hsa-miR-15a	hsa-mir-15a	13	17707831
hsa-miR-15a	hsa-mir-15a	13	16616063
hsa-miR-15a*	hsa-mir-15a	13	21205967
hsa-miR-15a*	hsa-mir-15a	13	18348159
hsa-miR-15a*	hsa-mir-15a	13	17707831
hsa-miR-15a*	hsa-mir-15a	13	16616063
hsa-miR-15b	hsa-mir-15b	3	16616063
hsa-miR-15b*	hsa-mir-15b	3	16616063
hsa-miR-16	hsa-mir-16-1	13	21205967
hsa-miR-16	hsa-mir-16-2	3	21205967
hsa-miR-16	hsa-mir-16-1	13	18348159
hsa-miR-16	hsa-mir-16-2	3	18348159
hsa-miR-16	hsa-mir-16-1	13	17941951
hsa-miR-16	hsa-mir-16-2	3	17941951
hsa-miR-16	hsa-mir-16-1	13	17707831
hsa-miR-16	hsa-mir-16-2	3	17707831
hsa-miR-16	hsa-mir-16-1	13	16616063
hsa-miR-16	hsa-mir-16-2	3	16616063
hsa-miR-16-1*	hsa-mir-16-1	13	17707831
hsa-miR-16-1*	hsa-mir-16-1	13	16616063
hsa-miR-181a	hsa-mir-181a-2	9	19717645
hsa-miR-181a	hsa-mir-181a-1	1	19717645
hsa-miR-181a	hsa-mir-181a-2	9	17707831
hsa-miR-181a	hsa-mir-181a-1	1	17707831
hsa-miR-181a	hsa-mir-181a-2	9	16762861
hsa-miR-181a	hsa-mir-181a-1	1	16762861
hsa-miR-181a*	hsa-mir-181a-1	1	19717645
hsa-miR-181a*	hsa-mir-181a-1	1	17707831
hsa-miR-181a-2*	hsa-mir-181a-2	9	19717645
hsa-miR-181a-2*	hsa-mir-181a-2	9	17707831
hsa-miR-181b	hsa-mir-181b-1	1	19717645
hsa-miR-181b	hsa-mir-181b-2	9	19717645
hsa-miR-181b	hsa-mir-181b-1	1	17707831
hsa-miR-181b	hsa-mir-181b-2	9	17707831
hsa-miR-181c	hsa-mir-181c	19	19717645
hsa-miR-181c	hsa-mir-181c	19	17707831
hsa-miR-181c*	hsa-mir-181c	19	19717645
hsa-miR-181c*	hsa-mir-181c	19	17707831
hsa-miR-181d	hsa-mir-181d	19	19717645
hsa-miR-181d	hsa-mir-181d	19	17707831
hsa-miR-21	hsa-mir-21	17	18348159
hsa-miR-21*	hsa-mir-21	17	18348159
hsa-miR-223	hsa-mir-223	X	20862275
hsa-miR-223	hsa-mir-223	X	19717645
hsa-miR-223	hsa-mir-223	X	19144983
hsa-miR-223*	hsa-mir-223	X	20862275
hsa-miR-223*	hsa-mir-223	X	19717645
hsa-miR-223*	hsa-mir-223	X	19144983
hsa-miR-29a	hsa-mir-29a	7	17707831
hsa-miR-29a*	hsa-mir-29a	7	17707831
hsa-miR-29b	hsa-mir-29b-1	7	19717645
hsa-miR-29b	hsa-mir-29b-2	1	19717645
hsa-miR-29b	hsa-mir-29b-1	7	17707831
hsa-miR-29b	hsa-mir-29b-2	1	17707831
hsa-miR-29b-1*	hsa-mir-29b-1	7	17707831
hsa-miR-29b-2*	hsa-mir-29b-2	1	17707831
hsa-miR-29c	hsa-mir-29c	1	20862275
hsa-miR-29c	hsa-mir-29c	1	19717645
hsa-miR-29c	hsa-mir-29c	1	19144983
hsa-miR-29c	hsa-mir-29c	1	17707831
hsa-miR-29c*	hsa-mir-29c	1	20862275
hsa-miR-29c*	hsa-mir-29c	1	19717645
hsa-miR-29c*	hsa-mir-29c	1	19144983
hsa-miR-29c*	hsa-mir-29c	1	17707831
hsa-miR-34a	hsa-mir-34a	1	21205967
hsa-miR-34a	hsa-mir-34a	1	19717645
hsa-miR-34a*	hsa-mir-34a	1	21205967
hsa-miR-34a*	hsa-mir-34a	1	19717645
hsa-miR-34b	hsa-mir-34b	11	21205967
hsa-miR-34b*	hsa-mir-34b	11	21205967
hsa-miR-34c-3p	hsa-mir-34c	11	21205967
hsa-miR-34c-5p	hsa-mir-34c	11	21205967
hsa-miR-640	hsa-mir-640	19	19717645

Cis-Nats regulation

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Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for ZAP70

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics