AutismKB 2.0

Annotation Detail for CA12


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Basic Information Top
Gene Symbol:CA12 ( CAXII,FLJ20151,HsT18816 )
Gene Full Name: carbonic anhydrase XII
Band: 15q22.2
Quick LinksEntrez ID:771; OMIM: 603263; Uniprot ID:CAH12_HUMAN; ENSEMBL ID: ENSG00000074410; HGNC ID: 1371
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
28N-linked (GlcNAc...) (Potential).
80N-linked (GlcNAc...) (Potential).
162N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
28N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
80N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
162N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
23Phosphoserine(CDC2)HMM predict
23Phosphoserine(IKK)HMM predict
23Phosphoserine(MAPK)HMM predict
23O-linkedHMM predict
28N-linkedHMM predict
72Phosphothreonine(MAPK)HMM predict
180N-linkedHMM predict
195Phosphotyrosine(Jak)HMM predict
227O-linkedHMM predict
231N-linkedHMM predict
266Phosphoserine(IKK)HMM predict
331Phosphoserine(PKG)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001218
  • Location:chr15 61402783-61461127
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 61474722 61475670 948 14069
Nanog ESGSE20650 61475684 61476231 547 14830
Nanog hESGSE18292 61475712 61476287 575 14872
Oct1 H2O2-HelaGSE14283 61472941 61472988 47 11837
Oct1 H2O2-HelaGSE14283 61480600 61480636 36 19491
Oct1 HelaGSE14283 61472941 61472988 47 11837
Oct1 HelaGSE14283 61480600 61480636 36 19491
RARA MCF7GSE15244 61466609 61467940 1331 6147
Sox2 hESGSE18292 61475700 61476131 431 14788
TFAP2C MCF7GSE21234 61466681 61467443 762 5935
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 61406279 61406451 172 0
CTCF G2GSE9613 61409083 61409361 278 0
CTCF G2GSE9613 61424592 61424959 367 0
ER MCF7GSE19013 61459337 61460193 856 0
Fos K562GSE19551 61424048 61424750 702 0
Myc K562GSE19551 61424053 61424469 416 0
Oct1 HelaGSE14283 61408720 61408754 34 0
RARA MCF7GSE15244 61457651 61459909 2258 0
TFAP2C MCF7GSE21234 61414184 61414791 607 0
TFAP2C MCF7GSE21234 61458673 61459087 414 0
hScc1 BcellGSE12603 61447803 61448159 356 0
p130 SenescentGSE19898 61412066 61412490 424 0
p130 SenescentGSE19898 61451492 61452330 838 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1031 Unknown pSILAC miR-16 CA12 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000074410 n_a n_a n_a "epithelium, leukocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018