AutismKB 2.0

Annotation Detail for MAP3K12


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Basic Information Top
Gene Symbol:MAP3K12 ( DLK,MEKK12,MUK,ZPK,ZPKP1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 12
Band: 12q13.13
Quick LinksEntrez ID:7786; OMIM: 600447; Uniprot ID:M3K12_HUMAN; ENSEMBL ID: ENSG00000139625; HGNC ID: 6851
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
634Phosphoserine.
757Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
9Phosphothreonine(MAPK)HMM predict
11Phosphoserine(PKB)HMM predict
11Phosphoserine(CDC2)HMM predict
37Phosphothreonine(CDC2)HMM predict
43Phosphothreonine(MAPK)HMM predict
45Phosphothreonine(MAPK)HMM predict
64Phosphoserine(CDK)HMM predict
94S-palmitoylHMM predict
209Phosphothreonine(PKA)HMM predict
209Phosphothreonine(MAPK)HMM predict
209Phosphothreonine(CDK)HMM predict
262Phosphoserine(CK1)HMM predict
269Phosphoserine(IKK)HMM predict
310Phosphotyrosine(Syk)HMM predict
334Phosphoserine(IKK)HMM predict
373Phosphoserine(CK1)HMM predict
374Phosphothreonine(MAPK)HMM predict
374Phosphothreonine(CDK)HMM predict
440Phosphotyrosine(INSR)HMM predict
500Phosphoserine(CDC2)HMM predict
536Phosphoserine(CDC2)HMM predict
536O-linkedHMM predict
536Phosphoserine(MAPK)HMM predict
540Phosphoserine(PKC)HMM predict
545Phosphothreonine(PKC)HMM predict
551Phosphoserine(PKG)HMM predict
576O-linkedHMM predict
576Phosphoserine(CDC2)HMM predict
607Phosphoserine(PKG)HMM predict
607Phosphoserine(IKK)HMM predict
607Phosphoserine(PKA)HMM predict
634Phosphoserine(ATM)HMM predict
634O-linkedHMM predict
642Phosphothreonine(CDK)HMM predict
642PhosphothreonineHMM predict
642Phosphothreonine(MAPK)HMM predict
645O-linkedHMM predict
648Phosphoserine(IKK)HMM predict
652O-linkedHMM predict
652Phosphoserine(IKK)HMM predict
653O-linkedHMM predict
654Phosphoserine(CDK)HMM predict
654Phosphoserine(IKK)HMM predict
654Phosphoserine(CDC2)HMM predict
657Phosphoserine(CDC2)HMM predict
688MethylarginineHMM predict
692MethylarginineHMM predict
695Phosphoserine(IKK)HMM predict
699Phosphothreonine(MAPK)HMM predict
718Phosphoserine(PKG)HMM predict
718Phosphoserine(CK2)HMM predict
718PhosphoserineHMM predict
719Phosphoserine(CK2)HMM predict
719PhosphoserineHMM predict
735Phosphoserine(ATM)HMM predict
747Phosphoserine(PKG)HMM predict
752Phosphoserine(CK1)HMM predict
765O-linkedHMM predict
765O-linkedHMM predict
765Phosphoserine(IKK)HMM predict
768Phosphoserine(IKK)HMM predict
768Phosphoserine(CDC2)HMM predict
768O-linkedHMM predict
770O-linkedHMM predict
793Phosphoserine(ATM)HMM predict
805O-linkedHMM predict
814O-linkedHMM predict
815Phosphoserine(IKK)HMM predict
815O-linkedHMM predict
839Phosphoserine(CK1)HMM predict
839Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006301
  • Location:chr12 52160546-52179537
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Rb GrowingGSE19898 52179475 52179648 173 24
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 52161956 52163772 1816 0
CTCF G2GSE9613 52172468 52172811 343 0
CTCF G2GSE9613 52173167 52173511 344 0
CTCF G2GSE9613 52177343 52177779 436 0
CTCF G2GSE9613 52178750 52180175 1425 0
FOXA1 MCF7GSE15244 52173278 52173878 600 0
H3ac HepG2E 52173589 52174022 433 0
H3ac HepG2E 52178680 52179178 498 0
KLF4 hESGSE17917 52172877 52173319 442 0
NRSF pAbJurkat 52162810 52163204 394 0
NRSF pAbJurkat 52173278 52173692 414 0
NRSF pAbJurkat 52179249 52179454 205 0
Oct1 H2O2-HelaGSE14283 52162672 52162703 31 0
Oct1 HelaGSE14283 52162659 52162706 47 0
Rb GrowingGSE19898 52172614 52172769 155 0
Rb QuiescentGSE19898 52173312 52173447 135 0
Rb SenescentGSE19898 52179378 52179654 276 0
TFAP2C MCF7GSE21234 52172824 52173626 802 0
USF1 HepG2E 52172172 52174912 2740 0
USF1 HepG2E 52175824 52176632 808 0
USF1 HepG2E 52177313 52178358 1045 0
USF1 HepG2E 52178649 52179178 529 0
USF2 HepG2E 52173321 52174912 1591 0
VDR GM10861-UnstimGSE22484 52159328 52167059 7731 0
VDR GM10861-stimGSE22484 52158487 52168331 9844 0
p130 QuiescentGSE19898 52172783 52173058 275 0
p130 SenescentGSE19898 52172824 52173051 227 0
p130 SenescentGSE19898 52173124 52173353 229 0
p130 shRbSenescentGSE19898 52172832 52173286 454 0
p63 keratinocytesGSE17611 52178512 52179470 958 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-100 hsa-mir-100 11 19851984
hsa-miR-100* hsa-mir-100 11 19851984
hsa-miR-124 hsa-mir-124-1 8 19851984
hsa-miR-124* hsa-mir-124-1 8 19851984
hsa-miR-17 hsa-mir-17 13 19666108
hsa-miR-17* hsa-mir-17 13 19666108
hsa-miR-196a hsa-mir-196a-2 12 19851984
hsa-miR-196a* hsa-mir-196a-2 12 19851984
hsa-miR-20a hsa-mir-20a 13 19666108
hsa-miR-20a* hsa-mir-20a 13 19666108
hsa-miR-219-1-3p hsa-mir-219-1 6 19851984
hsa-miR-219-5p hsa-mir-219-1 6 19851984
hsa-miR-26a hsa-mir-26a-1 3 19851984
hsa-miR-26a hsa-mir-26a-2 12 19851984
hsa-miR-26a-1* hsa-mir-26a-1 3 19851984
hsa-miR-30a hsa-mir-30a 6 19851984
hsa-miR-30a* hsa-mir-30a 6 19851984
hsa-miR-30c hsa-mir-30c-1 1 19851984
hsa-miR-30c-1* hsa-mir-30c-1 1 19851984
hsa-miR-373 hsa-mir-373 19 19851984
hsa-miR-373* hsa-mir-373 19 19851984
hsa-miR-423-3p hsa-mir-423 17 19851984
hsa-miR-423-5p hsa-mir-423 17 19851984
hsa-miR-492 hsa-mir-492 12 19851984
hsa-miR-604 hsa-mir-604 10 19851984
hsa-miR-608 hsa-mir-608 10 19851984
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
6060 mRNA chr12 52142541 52160858 312 mRNA MAP3K12 chr12 52160546 52179538Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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