AutismKB 2.0

Annotation Detail for ZYX


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Basic Information Top
Gene Symbol:ZYX ( ESP-2,HED-2 )
Gene Full Name: zyxin
Band: 7q34
Quick LinksEntrez ID:7791; OMIM: 602002; Uniprot ID:ZYX_HUMAN; ENSEMBL ID: ENSG00000159840; HGNC ID: 13200
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
142Phosphoserine.
143Phosphoserine.
159Phosphothreonine (By similarity).
169Phosphoserine.
179Phosphothreonine.
259Phosphoserine.
267Phosphoserine.
270Phosphothreonine.
274Phosphothreonine.
279N6-acetyllysine.
281Phosphoserine.
288Phosphoserine.
290Phosphoserine.
308Phosphoserine.
313Phosphoserine.
344Phosphoserine.
Location(AA) Modifications Resource
259Phosphoserine.Swiss-Prot 53.0
259PhosphoserinePhospho.ELM 6.0
267Phosphoserine.Swiss-Prot 53.0
267PhosphoserinePhospho.ELM 6.0
281Phosphoserine.Swiss-Prot 53.0
290Phosphoserine.Swiss-Prot 53.0
303PhosphoserinePhospho.ELM 6.0
308PhosphoserinePhospho.ELM 6.0
344Phosphoserine.Swiss-Prot 53.0
344PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
7Phosphoserine(CDC2)HMM predict
54MethylarginineHMM predict
116Phosphoserine(CDK)HMM predict
116Phosphoserine(CDC2)HMM predict
116O-linkedHMM predict
153Phosphoserine(CK1)HMM predict
172Phosphotyrosine(EGFR)HMM predict
172Phosphotyrosine(Jak)HMM predict
179O-linkedHMM predict
179O-linkedHMM predict
179Phosphothreonine(CDK)HMM predict
182O-linkedHMM predict
185Phosphoserine(CDC2)HMM predict
206Phosphoserine(ATM)HMM predict
218Phosphoserine(ATM)HMM predict
246Phosphoserine(IKK)HMM predict
258O-linkedHMM predict
259PhosphoserineHMM predict
259O-linkedHMM predict
259Phosphoserine(CDC2)HMM predict
267Phosphoserine(CDC2)HMM predict
270O-linkedHMM predict
281Phosphoserine(CDC2)HMM predict
281O-linkedHMM predict
288O-linkedHMM predict
290Phosphoserine(ATM)HMM predict
290Phosphoserine(IKK)HMM predict
308Phosphoserine(CDK)HMM predict
308Phosphoserine(CDC2)HMM predict
344Phosphoserine(CDC2)HMM predict
352Phosphothreonine(PKC)HMM predict
564LysineHMM predict
565S-palmitoylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001010972
  • Location:chr7 142788481-142798323
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 142779125 142779708 583 9065
CTCF G2GSE9613 142780603 142781123 520 7619
CTCF G2GSE9613 142787046 142788990 1944 464
Oct1 HelaGSE14283 142780942 142781007 65 7507
Oct1 HelaGSE14283 142783409 142783440 31 5057
Rb GrowingGSE19898 142787846 142787969 123 574
Rb QuiescentGSE19898 142787151 142787286 135 1263
Rb SenescentGSE19898 142788160 142788654 494 75
TFAP2C MCF7GSE21234 142787250 142788608 1358 553
hScc1 BcellGSE12603 142787418 142787906 488 820
hScc1 CdLSGSE12603 142787418 142788009 591 768
hScc1 G2GSE9613 142787478 142789061 1583 212
p130 QuiescentGSE19898 142787248 142787377 129 1169
p130 QuiescentGSE19898 142787771 142788043 272 575
p130 SenescentGSE19898 142787901 142788110 209 476
p130 shRbQuiescentGSE19898 142787848 142788338 490 389
p130 shRbSenescentGSE19898 142788332 142788567 235 32
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 142790279 142790691 412 0
CTCF G2GSE9613 142793338 142796146 2808 0
PHF8 HeLaGSE20725 142787525 142789642 2117 0
Pol2 GM12878GSE19551 142793113 142793441 328 0
Rb shRbQuiescentGSE19898 142793464 142793676 212 0
TAF HelaGSE8489 142791286 142792525 1239 0
hScc1 BcellGSE12603 142788465 142789318 853 0
p130 SenescentGSE19898 142789058 142789258 200 0
p130 shRbQuiescentGSE19898 142788768 142789648 880 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
24775 mRNA ZYX chr7 142595196 142605039 322 EST chr7 142604717 142605566Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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