AutismKB 2.0

Annotation Detail for DDR1


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Basic Information Top
Gene Symbol:DDR1 ( CAK,CD167,DDR,EDDR1,HGK2,MCK10,NEP,NTRK4,PTK3,PTK3A,RTK6,TRKE )
Gene Full Name: discoidin domain receptor tyrosine kinase 1
Band: 6p21.33
Quick LinksEntrez ID:780; OMIM: 600408; Uniprot ID:DDR1_HUMAN; ENSEMBL ID: ENSG00000204580; HGNC ID: 2730
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
211N-linked (GlcNAc...) (Potential).
260N-linked (GlcNAc...) (Potential).
371N-linked (GlcNAc...) (Potential).
394N-linked (GlcNAc...) (Potential).
484PPxY motif.
513Phosphotyrosine; by autocatalysis (By
631Phosphoserine.
792Phosphotyrosine; by autocatalysis (By
796Phosphotyrosine; by autocatalysis (By
797Phosphotyrosine; by autocatalysis (By
Location(AA) Modifications Resource
211N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
260N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
371N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
394N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
513Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
513PhosphotyrosinePhospho.ELM 6.0
792Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
796Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
797Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
52Phosphoserine(IKK)HMM predict
67Phosphoserine(ATM)HMM predict
86Phosphotyrosine(Jak)HMM predict
86Phosphotyrosine(SRC)HMM predict
86Phosphotyrosine(Syk)HMM predict
142Phosphoserine(CK2)HMM predict
211N-linkedHMM predict
260N-linkedHMM predict
267Phosphotyrosine(INSR)HMM predict
267Phosphotyrosine(EGFR)HMM predict
267Phosphotyrosine(Jak)HMM predict
370N-linkedHMM predict
371N-linkedHMM predict
393O-linkedHMM predict
394N-linkedHMM predict
448Phosphoserine(CAMK2)HMM predict
484Phosphotyrosine(SRC)HMM predict
484Phosphotyrosine(Abl)HMM predict
490MethylarginineHMM predict
547Phosphotyrosine(Syk)HMM predict
547Phosphotyrosine(INSR)HMM predict
547SulfotyrosineHMM predict
586Phosphotyrosine(Abl)HMM predict
586Phosphotyrosine(INSR)HMM predict
796Phosphotyrosine(Jak)HMM predict
899Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001954
  • Location:chr6 30959839-30975909
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 30953545 30953746 201 6194
CTCF CD4SISSRdata 30953545 30953746 201 6194
CTCF HelaGSE12889 30953535 30953772 237 6186
CTCF JurkatGSE12889 30953389 30953744 355 6273
CTCF G2GSE9613 30953342 30954123 781 6107
CTCF G2GSE9613 30956749 30956970 221 2980
CTCF G2GSE9613 30957416 30957930 514 2167
H3ac HepG2E 30954436 30954768 332 5238
H3ac HepG2E 30957390 30957831 441 2229
H3ac HepG2E 30958789 30959254 465 818
Myc K562GSE19551 30948157 30949268 1111 11127
Oct1 HelaGSE14283 30953760 30953832 72 6044
RARA MCF7GSE15244 30953342 30953623 281 6357
TFAP2C MCF7GSE21234 30959457 30960001 544 111
hScc1 BcellGSE12603 30953342 30953809 467 6264
hScc1 BcellGSE12603 30959006 30959363 357 655
hScc1 CdLSGSE12603 30953342 30953809 467 6264
hScc1 G2GSE9613 30953342 30954332 990 6003
p130 QuiescentGSE19898 30958039 30958267 228 1687
No data
No data
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-199a-5p hsa-mir-199a-1 19 20799954
hsa-miR-199a-5p hsa-mir-199a-2 1 20799954
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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