AutismKB 2.0

Annotation Detail for CXCR4


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Basic Information Top
Gene Symbol:CXCR4 ( CD184,D2S201E,FB22,HM89,HSY3RR,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM )
Gene Full Name: chemokine (C-X-C motif) receptor 4
Band: 2q22.1
Quick LinksEntrez ID:7852; OMIM: 162643; Uniprot ID:CXCR4_HUMAN; ENSEMBL ID: ENSG00000121966; HGNC ID: 2561
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
11N-linked (GlcNAc...).
18O-linked (Xyl...) (chondroitin sulfate).
21Sulfotyrosine.
135Important for signaling.
176N-linked (GlcNAc...) (Potential).
319Phosphoserine.
321Phosphoserine.
324Phosphoserine; by PKC and GRK6.
325Phosphoserine; by PKC and GRK6.
330Phosphoserine; by GRK6.
339Phosphoserine; by GRK6.
348Phosphoserine.
351Phosphoserine.
Location(AA) Modifications Resource
11N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
21Sulfotyrosine (Potential).Swiss-Prot 53.0
176N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
319PhosphoserinePhospho.ELM 6.0
346PhosphoserinePhospho.ELM 6.0
348PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
11N-linkedHMM predict
12SulfotyrosineHMM predict
12Phosphotyrosine(INSR)HMM predict
21Phosphotyrosine(Syk)HMM predict
21Phosphotyrosine(INSR)HMM predict
21SulfotyrosineHMM predict
76Phosphotyrosine(Jak)HMM predict
176N-linkedHMM predict
220S-palmitoylHMM predict
229Phosphoserine(CK1)HMM predict
295S-palmitoylHMM predict
296S-palmitoylHMM predict
321O-linkedHMM predict
342Phosphothreonine(CK2)HMM predict
344Phosphoserine(CK2)HMM predict
347Phosphoserine(CK1)HMM predict
348Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001008540
  • Location:chr2 136588389-136590282
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 136575987 136576017 30 12388
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K27me3 colorectalcancer 136588371 136589913 1542 0
PolII HeLaGSE12783 136586352 136592671 6319 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-10a hsa-mir-10a 17 18647411
hsa-miR-10a hsa-mir-10a 17 18647411
hsa-miR-10a* hsa-mir-10a 17 18647411
hsa-miR-10a* hsa-mir-10a 17 18647411
hsa-miR-126 hsa-mir-126 9 19996457
hsa-miR-126 hsa-mir-126 9 18647411
hsa-miR-126 hsa-mir-126 9 19996457
hsa-miR-126 hsa-mir-126 9 18647411
hsa-miR-126* hsa-mir-126 9 19996457
hsa-miR-126* hsa-mir-126 9 18647411
hsa-miR-126* hsa-mir-126 9 19996457
hsa-miR-126* hsa-mir-126 9 18647411
hsa-miR-142-3p hsa-mir-142 17 18647411
hsa-miR-142-3p hsa-mir-142 17 18647411
hsa-miR-146a hsa-mir-146a 5 20023696
hsa-miR-146a hsa-mir-146a 5 18568019
hsa-miR-146a hsa-mir-146a 5 20023696
hsa-miR-146a hsa-mir-146a 5 18568019
hsa-miR-146a* hsa-mir-146a 5 20023696
hsa-miR-146a* hsa-mir-146a 5 18568019
hsa-miR-146a* hsa-mir-146a 5 20023696
hsa-miR-146a* hsa-mir-146a 5 18568019
hsa-miR-155 hsa-mir-155 21 17889832
hsa-miR-155 hsa-mir-155 21 17889832
hsa-miR-155* hsa-mir-155 21 17889832
hsa-miR-155* hsa-mir-155 21 17889832
hsa-miR-17 hsa-mir-17 13 18647411
hsa-miR-17 hsa-mir-17 13 18647411
hsa-miR-17* hsa-mir-17 13 18647411
hsa-miR-17* hsa-mir-17 13 18647411
hsa-miR-221 hsa-mir-221 X 18647411
hsa-miR-221 hsa-mir-221 X 18647411
hsa-miR-221* hsa-mir-221 X 18647411
hsa-miR-221* hsa-mir-221 X 18647411
hsa-miR-224 hsa-mir-224 X 20023705
hsa-miR-224 hsa-mir-224 X 20023705
hsa-miR-429 hsa-mir-429 1 21233447
hsa-miR-429 hsa-mir-429 1 21233447
hsa-miR-92a hsa-mir-92a-1 13 18647411
hsa-miR-92a hsa-mir-92a-2 X 18647411
hsa-miR-92a hsa-mir-92a-1 13 18647411
hsa-miR-92a hsa-mir-92a-2 X 18647411
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018