AutismKB 2.0

Annotation Detail for CAD


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Basic Information Top
Gene Symbol:CAD ( - )
Gene Full Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Band: 2p23.3
Quick LinksEntrez ID:790; OMIM: 114010; Uniprot ID:PYR1_HUMAN; ENSEMBL ID: ENSG00000084774; HGNC ID: 1424
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
747N6-acetyllysine.
1037Phosphothreonine.
1038Phosphoserine.
1411N6-acetyllysine.
1423Phosphoserine.
1823Phosphoserine.
1859Phosphoserine.
1884Phosphothreonine.
Location(AA) Modifications Resource
456Phosphothreonine (MAPK1;MAPK3)Phospho.ELM 6.0
1823Phosphoserine.Swiss-Prot 53.0
1823PhosphoserinePhospho.ELM 6.0
1859Phosphoserine.Swiss-Prot 53.0
1859PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
92S-palmitoylHMM predict
94O-linkedHMM predict
141N-linkedHMM predict
194S-palmitoylHMM predict
211Phosphoserine(ATM)HMM predict
214Phosphotyrosine(Syk)HMM predict
241Phosphoserine(CK1)HMM predict
369Phosphothreonine(PKC)HMM predict
385Phosphothreonine(CDK)HMM predict
388O-linkedHMM predict
417Phosphoserine(ATM)HMM predict
537Phosphoserine(CK1)HMM predict
602Phosphotyrosine(SRC)HMM predict
602Phosphotyrosine(Jak)HMM predict
639Phosphothreonine(PKC)HMM predict
678Phosphotyrosine(Syk)HMM predict
679SulfotyrosineHMM predict
688Phosphoserine(PKG)HMM predict
721Phosphoserine(CK1)HMM predict
916Phosphotyrosine(Jak)HMM predict
918Phosphotyrosine(Jak)HMM predict
1169Phosphothreonine(CDK)HMM predict
1169Phosphothreonine(MAPK)HMM predict
1406Phosphoserine(PKC)HMM predict
1406Phosphoserine(PKA)HMM predict
1560N-linkedHMM predict
1595Phosphothreonine(PKC)HMM predict
1606Phosphothreonine(PKC)HMM predict
1691Phosphothreonine(PKC)HMM predict
1749Phosphotyrosine(Syk)HMM predict
1749Phosphotyrosine(Jak)HMM predict
1749Phosphotyrosine(EGFR)HMM predict
1749PhosphotyrosineHMM predict
1749Phosphotyrosine(SRC)HMM predict
1782Phosphothreonine(PKC)HMM predict
1805Phosphotyrosine(Abl)HMM predict
1828O-linkedHMM predict
1828O-linkedHMM predict
1833Phosphothreonine(CDC2)HMM predict
1848MethylarginineHMM predict
1884PhosphothreonineHMM predict
1888O-linkedHMM predict
1933Phosphothreonine(CK2)HMM predict
1995O-linkedHMM predict
1999Phosphoserine(CK1)HMM predict
2010O-linkedHMM predict
2013Phosphothreonine(PKC)HMM predict
2108O-linkedHMM predict
2131Phosphoserine(CK2)HMM predict
2158Phosphotyrosine(Syk)HMM predict
2212Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004341
  • Location:chr2 27293761-27320156
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
KLF4 hESGSE17917 27321673 27321840 167 1600
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 27293658 27293885 227 0
CTCF CD4SISSRdata 27293658 27293885 227 0
CTCF G2GSE9613 27293703 27294388 685 0
CTCF G2GSE9613 27317757 27318548 791 0
H3ac HepG2E 27294496 27295079 583 0
Myc K562GSE19551 27293431 27294537 1106 0
Myc hESGSE17917 27293750 27294111 361 0
Oct1 HelaGSE14283 27307718 27307750 32 0
PHF8 HeLaGSE20725 27293326 27294502 1176 0
Rb GrowingGSE19898 27293738 27294262 524 0
Rb QuiescentGSE19898 27293713 27294418 705 0
Rb SenescentGSE19898 27293619 27294320 701 0
Rb shRbSenescenceGSE19898 27294086 27294242 156 0
hScc1 BcellGSE12603 27293556 27294496 940 0
p130 SenescentGSE19898 27293597 27294303 706 0
p130 shRbQuiescentGSE19898 27293788 27294399 611 0
p130 shRbSenescentGSE19898 27293734 27294333 599 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018