AutismKB 2.0

Annotation Detail for FYCO1


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Basic Information Top
Gene Symbol:FYCO1 ( DKFZp779K1152,FLJ13335,MGC126517,MGC126519,RUFY3,ZFYVE7 )
Gene Full Name: FYVE and coiled-coil domain containing 1
Band: 3p21.31
Quick LinksEntrez ID:79443; OMIM: 607182; Uniprot ID:FYCO1_HUMAN; ENSEMBL ID: ENSG00000163820; HGNC ID: 14673
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
381Phosphothreonine (By similarity).
878Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
199O-linkedHMM predict
200Phosphoserine(IKK)HMM predict
202Phosphoserine(CK1)HMM predict
268Phosphoserine(PKG)HMM predict
276Phosphothreonine(PKC)HMM predict
311Phosphothreonine(PKC)HMM predict
342Phosphoserine(IKK)HMM predict
460Phosphoserine(CK1)HMM predict
510Phosphoserine(CK1)HMM predict
530Phosphoserine(CK2)HMM predict
547Phosphoserine(ATM)HMM predict
662Phosphoserine(MAPK)HMM predict
735Phosphoserine(PKC)HMM predict
735Phosphoserine(IKK)HMM predict
774Phosphoserine(ATM)HMM predict
884Phosphoserine(CK1)HMM predict
991Phosphoserine(PKG)HMM predict
1027Phosphoserine(CK1)HMM predict
1131N-linkedHMM predict
1165Phosphoserine(CK2)HMM predict
1203S-palmitoylHMM predict
1223S-palmitoylHMM predict
1236Phosphoserine(IKK)HMM predict
1236Phosphoserine(CDC2)HMM predict
1236Phosphoserine(ATM)HMM predict
1239O-linkedHMM predict
1240Phosphoserine(CK1)HMM predict
1240O-linkedHMM predict
1242Phosphoserine(CK2)HMM predict
1242O-linkedHMM predict
1242Phosphoserine(IKK)HMM predict
1242Phosphoserine(CK1)HMM predict
1245Phosphoserine(ATM)HMM predict
1250O-linkedHMM predict
1254O-linkedHMM predict
1254Phosphoserine(CDK)HMM predict
1254Phosphoserine(CDC2)HMM predict
1254Phosphoserine(ATM)HMM predict
1257O-linkedHMM predict
1257Phosphoserine(MAPK)HMM predict
1257Phosphoserine(CDC2)HMM predict
1257Phosphoserine(CDK)HMM predict
1272Phosphotyrosine(Syk)HMM predict
1272SulfotyrosineHMM predict
1272Phosphotyrosine(INSR)HMM predict
1284Phosphothreonine(CK2)HMM predict
1297O-linkedHMM predict
1297Phosphoserine(CK1)HMM predict
1297Phosphoserine(IKK)HMM predict
1301Phosphothreonine(CDK)HMM predict
1301Phosphothreonine(MAPK)HMM predict
1317O-linkedHMM predict
1318O-linkedHMM predict
1319O-linkedHMM predict
1323Phosphothreonine(MAPK)HMM predict
1323Phosphothreonine(CDK)HMM predict
1374Phosphotyrosine(SRC)HMM predict
1398Phosphoserine(IKK)HMM predict
1411Phosphothreonine(MAPK)HMM predict
1444Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_024513
  • Location:chr3 45934399-46012303
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
p130 SenescentGSE19898 46012182 46012733 551 154
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 45930787 45934939 4152 1537
FOXA1 MCF7GSE15244 45932299 45932881 582 1810
P300 T30-glioblastomaGSE21026 45932222 45933064 842 1757
RARA MCF7GSE15244 45932041 45933024 983 1867
RARG MCF7GSE15244 45932151 45933024 873 1812
hScc1 BcellGSE12603 45931656 45932005 349 2569
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 45991223 45996660 5437 0
CTCF CD4GSE12889 45945482 45945844 362 0
CTCF CD4GSE12889 45955215 45955559 344 0
CTCF CD4SISSRdata 45945482 45945844 362 0
CTCF CD4SISSRdata 45955215 45955559 344 0
CTCF HelaGSE12889 45955345 45955669 324 0
CTCF G2GSE9613 45937528 45937810 282 0
CTCF G2GSE9613 45940237 45940486 249 0
CTCF G2GSE9613 45945603 45946341 738 0
CTCF G2GSE9613 45947461 45947687 226 0
CTCF G2GSE9613 45952827 45953473 646 0
CTCF G2GSE9613 45954395 45954688 293 0
CTCF G2GSE9613 45955407 45955842 435 0
CTCF G2GSE9613 45968179 45968433 254 0
CTCF G2GSE9613 45970885 45971045 160 0
CTCF G2GSE9613 45974103 45974421 318 0
CTCF G2GSE9613 45976907 45977097 190 0
CTCF G2GSE9613 45982341 45983106 765 0
CTCF G2GSE9613 45983568 45984101 533 0
CTCF G2GSE9613 46001857 46002075 218 0
CTCF G2GSE9613 46002725 46003138 413 0
CTCF G2GSE9613 46008010 46008225 215 0
CTCF G2GSE9613 46011908 46012465 557 0
ER MCF7GSE19013 46004303 46004818 515 0
ETS1 JurkatGSE17954 46011156 46012833 1677 0
FOXA1 MCF7GSE15244 45958608 45959113 505 0
FOXA1 MCF7GSE15244 45994803 45995324 521 0
FOXA1 MCF7GSE15244 46002725 46003508 783 0
FOXA1 MCF7GSE15244 46004036 46004431 395 0
Fos K562GSE19551 45997839 45998275 436 0
FoxA1 MCF7MACSdata 46002896 46003178 282 0
LIN9 SGSE7516 45964983 45965229 246 0
Myc hESGSE17917 45980603 45980828 225 0
NFkBII GM10847GSE19485 45978032 45979349 1317 0
NFkBII GM12878GSE19485 45978055 45979397 1342 0
NFkBII GM15510GSE19485 45978138 45979173 1035 0
NFkBII GM18526GSE19485 45978178 45979250 1072 0
Oct1 H2O2-HelaGSE14283 45966866 45966893 27 0
Oct1 HelaGSE14283 45966865 45966945 80 0
P300 T0-glioblastomaGSE21026 45989032 45989643 611 0
P300 T30-glioblastomaGSE21026 45988945 45989857 912 0
P300 T30-glioblastomaGSE21026 46011849 46012671 822 0
RARA MCF7GSE15244 46002725 46003281 556 0
RARA MCF7GSE15244 46003831 46004467 636 0
RARG MCF7GSE15244 46002725 46003249 524 0
RARG MCF7GSE15244 46004072 46004932 860 0
Rb GrowingGSE19898 45935585 45935790 205 0
Rb GrowingGSE19898 45989093 45989333 240 0
TFAP2C MCF7GSE21234 45940179 45940541 362 0
TFAP2C MCF7GSE21234 45984645 45985121 476 0
VDR GM10855-stimGSE22484 45978137 45979502 1365 0
VDR GM10861-stimGSE22484 45978034 45979901 1867 0
hScc1 BcellGSE12603 45944816 45946265 1449 0
hScc1 BcellGSE12603 45947461 45947642 181 0
hScc1 BcellGSE12603 45955407 45955979 572 0
hScc1 BcellGSE12603 45983637 45984073 436 0
hScc1 BcellGSE12603 46012109 46012465 356 0
hScc1 CdLSGSE12603 45945002 45946091 1089 0
hScc1 CdLSGSE12603 45955407 45955880 473 0
hScc1 G2GSE9613 45945695 45946377 682 0
hScc1 G2GSE9613 45955407 45955731 324 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
683 Unknown MicroArray miR-373 FYCO1 n_a 15685193
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000163820 n_a n_a n_a "lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
18019 mRNA CXCR6 chr3 45959976 45964849 4873 mRNA FYCO1 chr3 45934399 46012304 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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