AutismKB 2.0

Annotation Detail for PARP8


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Basic Information Top
Gene Symbol:PARP8 ( FLJ21308,MGC42864,pART16 )
Gene Full Name: poly (ADP-ribose) polymerase family, member 8
Band: 5q11.1
Quick LinksEntrez ID:79668; OMIM: NA; Uniprot ID:PARP8_HUMAN; ENSEMBL ID: ENSG00000151883; HGNC ID: 26124
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
760Phosphoserine.
767Phosphothreonine.
770Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
51Phosphoserine(PKB)HMM predict
53Phosphoserine(ATM)HMM predict
60SulfotyrosineHMM predict
91Phosphothreonine(PKC)HMM predict
120N-linkedHMM predict
121Phosphoserine(PKG)HMM predict
121Phosphoserine(PKB)HMM predict
127Phosphoserine(CK1)HMM predict
131N-linkedHMM predict
137Phosphotyrosine(Syk)HMM predict
138SulfotyrosineHMM predict
190Phosphoserine(CK2)HMM predict
272PhosphoserineHMM predict
291Phosphoserine(PKB)HMM predict
291O-linkedHMM predict
291Phosphoserine(PKA)HMM predict
324Phosphoserine(CDC2)HMM predict
386Phosphothreonine(PKC)HMM predict
435O-linkedHMM predict
456Phosphoserine(PKG)HMM predict
456Phosphoserine(PKA)HMM predict
466Phosphothreonine(MAPK)HMM predict
466O-linkedHMM predict
471Phosphoserine(CK1)HMM predict
473Phosphoserine(IKK)HMM predict
473Phosphoserine(CK1)HMM predict
473Phosphoserine(ATM)HMM predict
571Phosphoserine(CDC2)HMM predict
675Phosphoserine(CDC2)HMM predict
675Phosphoserine(MAPK)HMM predict
732Phosphotyrosine(INSR)HMM predict
760Phosphoserine(CDC2)HMM predict
761Phosphoserine(CK1)HMM predict
762Phosphoserine(IKK)HMM predict
765Phosphoserine(IKK)HMM predict
765O-linkedHMM predict
766N-linkedHMM predict
768Phosphoserine(ATM)HMM predict
768Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_024615
  • Location:chr5 49998569-50173925
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Fulvestrant-MCF7GSE14664 49997662 49997694 32 892
H3K4me2 HCT116GSE10453 49997243 49997775 532 1061
H3K4me3 colorectalcancer 49997171 49998082 911 943
Oct1 HelaGSE14283 49978744 49978774 30 19811
RARA MCF7GSE15244 49996959 49997730 771 1225
hScc1 BcellGSE12603 49997208 49997775 567 1078
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 50082574 50082978 404 0
CTCF CD4SISSRdata 50082574 50082978 404 0
CTCF G2GSE9613 49998162 49999540 1378 0
CTCF G2GSE9613 50082697 50083001 304 0
ER E2-MCF7GSE14664 50060705 50060738 33 0
ER E2-MCF7GSE14664 50163949 50163986 37 0
FOXA1 MCF7GSE15244 50014438 50014995 557 0
H3K4me2 HCT116GSE10453 49999576 50000349 773 0
H3K4me3 colorectalcancer 49999656 50000546 890 0
H3ac HepG2E 49999540 50000436 896 0
KLF4 hESGSE17917 50046287 50046523 236 0
NFkBII GM10847GSE19485 49997436 50000202 2766 0
NFkBII GM12878GSE19485 49998310 50000955 2645 0
NFkBII GM12892GSE19485 49997305 50000372 3067 0
NFkBII GM15510GSE19485 49997821 50000396 2575 0
NFkBII GM18526GSE19485 49997363 50000201 2838 0
Nanog hESGSE18292 50010294 50010505 211 0
Nanog hESGSE18292 50082763 50082932 169 0
Oct1 H2O2-HelaGSE14283 50081000 50081028 28 0
Oct1 H2O2-HelaGSE14283 50082406 50082436 30 0
Oct1 HelaGSE14283 50082405 50082445 40 0
Oct1 HelaGSE14283 50086270 50086304 34 0
Oct1 HelaGSE14283 50116269 50116324 55 0
Oct1 HelaGSE14283 50163949 50163983 34 0
Stat6 IL-4-hr4GSE17850 50021223 50021686 463 0
TAF HelaGSE8489 49999437 50000610 1173 0
TFAP2C MCF7GSE21234 50126393 50126784 391 0
hScc1 BcellGSE12603 49998538 50000031 1493 0
hScc1 BcellGSE12603 50082463 50083072 609 0
hScc1 CdLSGSE12603 49997313 50000110 2797 0
hScc1 CdLSGSE12603 50082512 50083138 626 0
p130 QuiescentGSE19898 49998860 49999094 234 0
p130 SenescentGSE19898 49998816 49999103 287 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 15131085
hsa-let-7b* hsa-let-7b 22 15131085
hsa-let-7e hsa-let-7e 19 15131085
hsa-let-7e* hsa-let-7e 19 15131085
hsa-miR-103 hsa-mir-103-2 20 15131085
hsa-miR-103 hsa-mir-103-1 5 15131085
hsa-miR-141 hsa-mir-141 12 15131085
hsa-miR-141* hsa-mir-141 12 15131085
hsa-miR-145 hsa-mir-145 5 15131085
hsa-miR-145* hsa-mir-145 5 15131085
hsa-miR-15a hsa-mir-15a 13 15131085
hsa-miR-15a* hsa-mir-15a 13 15131085
hsa-miR-15b hsa-mir-15b 3 15131085
hsa-miR-15b* hsa-mir-15b 3 15131085
hsa-miR-16 hsa-mir-16-1 13 15131085
hsa-miR-16 hsa-mir-16-2 3 15131085
hsa-miR-199b-3p hsa-mir-199b 9 15131085
hsa-miR-199b-5p hsa-mir-199b 9 15131085
hsa-miR-23a hsa-mir-23a 19 15131085
hsa-miR-23a* hsa-mir-23a 19 15131085
hsa-miR-24 hsa-mir-24-1 9 15131085
hsa-miR-24 hsa-mir-24-2 19 15131085
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
20929 mRNA PARP8 chr5 49998569 50173933 102 EST chr5 49998675 49998815Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018