AutismKB 2.0

Annotation Detail for LRRK1


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Basic Information Top
Gene Symbol:LRRK1 ( FLJ23119,FLJ27465,KIAA1790,RIPK6,Roco1 )
Gene Full Name: leucine-rich repeat kinase 1
Band: 15q26.3
Quick LinksEntrez ID:79705; OMIM: 610986; Uniprot ID:LRRK1_HUMAN; ENSEMBL ID: ENSG00000154237; HGNC ID: 18608
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
41MethylarginineHMM predict
171Phosphoserine(CDC2)HMM predict
206Phosphotyrosine(Syk)HMM predict
271O-linkedHMM predict
395N-linkedHMM predict
398N-linkedHMM predict
541Phosphothreonine(PKC)HMM predict
555Phosphoserine(PKG)HMM predict
557Phosphothreonine(PKC)HMM predict
683Phosphothreonine(PKC)HMM predict
796Phosphothreonine(PKC)HMM predict
807Phosphoserine(CDC2)HMM predict
807Phosphoserine(CDK)HMM predict
807Phosphoserine(IKK)HMM predict
812MethylarginineHMM predict
814O-linkedHMM predict
831Phosphoserine(IKK)HMM predict
913Phosphotyrosine(Syk)HMM predict
913SulfotyrosineHMM predict
1061Phosphoserine(PKG)HMM predict
1104N-linkedHMM predict
1121Phosphotyrosine(Jak)HMM predict
1123Phosphoserine(ATM)HMM predict
1127Phosphoserine(CK1)HMM predict
1202Phosphoserine(CK2)HMM predict
1205Phosphoserine(CK1)HMM predict
1210SulfotyrosineHMM predict
1264PhosphoserineHMM predict
1264Phosphoserine(CK1)HMM predict
1264Phosphoserine(CK2)HMM predict
1269Phosphoserine(CK1)HMM predict
1269Phosphoserine(IKK)HMM predict
1318Phosphothreonine(PKA)HMM predict
1323N-linkedHMM predict
1557S-palmitoylHMM predict
1565Phosphoserine(CDK)HMM predict
1584N-linkedHMM predict
1585Phosphotyrosine(INSR)HMM predict
1589N-linkedHMM predict
1601S-palmitoylHMM predict
1602S-palmitoylHMM predict
1627SulfotyrosineHMM predict
1664Phosphotyrosine(Jak)HMM predict
1691Phosphotyrosine(Jak)HMM predict
1698N-linkedHMM predict
1753Phosphotyrosine(INSR)HMM predict
1861Phosphotyrosine(INSR)HMM predict
1868O-linkedHMM predict
1870Phosphoserine(CDC2)HMM predict
1878O-linkedHMM predict
1880O-linkedHMM predict
1881Phosphoserine(IKK)HMM predict
1881O-linkedHMM predict
1881O-linkedHMM predict
1884Phosphoserine(CK1)HMM predict
1885Phosphoserine(ATM)HMM predict
1885Phosphoserine(IKK)HMM predict
1885Phosphoserine(CDC2)HMM predict
1885Phosphoserine(CDK)HMM predict
1889Phosphoserine(CK1)HMM predict
1914Phosphoserine(CK1)HMM predict
1927Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_024652
  • Location:chr15 99276982-99427837
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 99275775 99275983 208 1104
CTCF CD4SISSRdata 99275775 99275983 208 1104
CTCF G2GSE9613 99275368 99277030 1662 784
hScc1 BcellGSE12603 99275406 99276436 1030 1062
hScc1 BcellGSE12603 99276681 99277030 349 127
hScc1 CdLSGSE12603 99275443 99276650 1207 936
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 99428404 99429074 670 902
CBP T30-glioblastomaGSE21026 99428079 99428999 920 702
CTCF CD4GSE12889 99446514 99446822 308 18831
CTCF CD4SISSRdata 99446514 99446822 308 18831
CTCF G2GSE9613 99439004 99439194 190 11262
CTCF G2GSE9613 99445504 99447019 1515 18424
H3ac HepG2E 99446830 99447272 442 19214
Oct1 H2O2-HelaGSE14283 99438248 99438275 27 10424
Oct1 HelaGSE14283 99438232 99438281 49 10419
P300 T0-glioblastomaGSE21026 99428229 99429132 903 843
hScc1 BcellGSE12603 99429412 99429743 331 1740
hScc1 BcellGSE12603 99436581 99436956 375 8931
hScc1 BcellGSE12603 99439004 99439194 190 11262
hScc1 BcellGSE12603 99443756 99444370 614 16226
hScc1 BcellGSE12603 99445504 99447315 1811 18572
hScc1 CdLSGSE12603 99446318 99447272 954 18958
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 99315996 99317269 1273 0
CTCF CD4GSE12889 99372866 99373185 319 0
CTCF CD4SISSRdata 99372866 99373185 319 0
CTCF G2GSE9613 99277388 99277768 380 0
CTCF G2GSE9613 99330961 99331538 577 0
CTCF G2GSE9613 99364617 99365178 561 0
CTCF G2GSE9613 99366053 99366715 662 0
CTCF G2GSE9613 99368543 99368838 295 0
CTCF G2GSE9613 99372623 99373368 745 0
CTCF G2GSE9613 99374799 99375126 327 0
CTCF G2GSE9613 99385208 99385605 397 0
CTCF G2GSE9613 99403728 99404091 363 0
CTCF G2GSE9613 99410560 99411226 666 0
CTCF G2GSE9613 99414451 99414811 360 0
CTCF G2GSE9613 99426721 99427085 364 0
ER E2-MCF7GSE14664 99346449 99346486 37 0
ER E2-MCF7GSE14664 99367571 99367616 45 0
ER E2-MCF7GSE14664 99420381 99420422 41 0
ER Fulvestrant-MCF7GSE14664 99346445 99346486 41 0
Oct1 H2O2-HelaGSE14283 99282751 99282779 28 0
Oct1 HelaGSE14283 99297882 99297915 33 0
Oct1 HelaGSE14283 99319049 99319079 30 0
Oct1 HelaGSE14283 99346444 99346481 37 0
Oct1 HelaGSE14283 99366844 99366929 85 0
Oct1 HelaGSE14283 99384516 99384555 39 0
Oct1 HelaGSE14283 99387015 99387050 35 0
Oct1 HelaGSE14283 99403764 99403803 39 0
Oct1 HelaGSE14283 99420384 99420453 69 0
P300 T30-glioblastomaGSE21026 99315928 99317401 1473 0
Sox2 hESGSE18292 99427233 99427625 392 0
TFAP2C MCF7GSE21234 99366287 99367188 901 0
TFAP2C MCF7GSE21234 99426673 99427368 695 0
hScc1 BcellGSE12603 99331000 99331457 457 0
hScc1 BcellGSE12603 99364617 99365178 561 0
hScc1 BcellGSE12603 99366053 99366643 590 0
hScc1 BcellGSE12603 99368657 99368873 216 0
hScc1 BcellGSE12603 99372623 99373368 745 0
hScc1 BcellGSE12603 99382868 99383131 263 0
hScc1 BcellGSE12603 99400088 99400283 195 0
hScc1 BcellGSE12603 99411009 99411308 299 0
hScc1 BcellGSE12603 99417640 99417905 265 0
hScc1 BcellGSE12603 99421402 99422141 739 0
hScc1 BcellGSE12603 99423361 99423854 493 0
hScc1 CdLSGSE12603 99364617 99365178 561 0
hScc1 CdLSGSE12603 99372623 99373368 745 0
hScc1 G2GSE9613 99372623 99373368 745 0
p130 QuiescentGSE19898 99279853 99280005 152 0
p130 SenescentGSE19898 99316376 99316760 384 0
p130 shRbSenescentGSE19898 99381974 99382266 292 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
9381 mRNA LRRK1 chr15 99380194 99427834 5712 EST chr15 99401472 99407184 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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