Annotation Detail for DENND2D

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Basic Information Top

Gene Symbol:	DENND2D ( FLJ22457,RP5-1180E21.2 )
Gene Full Name:	DENN/MADD domain containing 2D
Band:	1p13.3-p13.2
Quick Links	Entrez ID:79961; OMIM: NA; Uniprot ID:DEN2D_HUMAN; ENSEMBL ID: ENSG00000162777; HGNC ID: 26192
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:6 results

No data

Location(AA)	Modification	Resource
67	Phosphoserine(CK2)	HMM predict
71	Phosphotyrosine(EGFR)	HMM predict
71	Phosphotyrosine(INSR)	HMM predict
71	Phosphotyrosine(SRC)	HMM predict
71	Phosphotyrosine(Syk)	HMM predict
71	Sulfotyrosine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_024901
Location:chr1 111531323-111544803
strand:-

Upstream the gene:15 results
Downstream the gene:0 results
Inside the gene:11 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CBP	Jurkat	GSE17954	111546617	111549601	2984	3306
CTCF	CD4	GSE12889	111548620	111548813	193	3913
CTCF	CD4	SISSRdata	111548620	111548813	193	3913
CTCF	G2	GSE9613	111548216	111548550	334	3580
ER	MCF7	GSE19013	111546948	111547805	857	2573
KLF4	hES	GSE17917	111548225	111548678	453	3648
RARA	MCF7	GSE15244	111544106	111546079	1973	289
RARA	MCF7	GSE15244	111546385	111547720	1335	2249
RARA	MCF7	GSE15244	111552054	111552447	393	7447
RARA	MCF7	GSE15244	111552855	111553416	561	8332
TFAP2C	MCF7	GSE21234	111544523	111545179	656	48
TFAP2C	MCF7	GSE21234	111545377	111545878	501	824
VDR	GM10861-stim	GSE22484	111546634	111550124	3490	3576
hScc1	Bcell	GSE12603	111547720	111548661	941	3387
hScc1	CdLS	GSE12603	111548145	111548876	731	3707

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	111541706	111541987	281	0
CTCF	CD4	SISSRdata	111541706	111541987	281	0
CTCF	G2	GSE9613	111536323	111536466	143	0
CTCF	G2	GSE9613	111541782	111542098	316	0
CTCF	G2	GSE9613	111544536	111544959	423	0
NFkBII	GM12878	GSE19485	111535708	111538491	2783	0
NFkBII	GM12892	GSE19485	111536221	111538338	2117	0
NFkBII	GM18526	GSE19485	111536220	111538264	2044	0
Pol2	GM12878	GSE19551	111541538	111546399	4861	0
hScc1	Bcell	GSE12603	111541649	111542133	484	0
hScc1	CdLS	GSE12603	111541649	111542227	578	0

Validated miRNA targets

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
1285	mRNA		chr1	111454989	111456942	267	mRNA	FLJ22457	chr1	111441842	111455323	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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